Abstract: The present invention provides therapeutic compositions and methods for treatment of bacterial vaginosis and restoration of the vaginal microbiome. The compositions include an active pharmaceutical ingredient a filler a binder and a gelling agent.

Abstract: A thrombectomy device includes a tubular shunt generally connected at an upstream end to a relatively high-pressure blood vessel such as an artery and at a downstream end to a relatively low-pressure blood vessel such as a vein. During use, the shunt is disposed mostly outside of the patient. A filter is disposed in the shunt for blocking the passage of clot particles. This device enables a real-time return of blood to the vascular system of the patient. A selectively operable syringe is operatively connected to the tubular member for exerting an auxiliary force on clot material stuck in one of the tubular member and the inlet port element. A three-way valve element is operable in first configuration to couple the suction device to the inlet port element, in a second configuration to couple the suction device to the outlet port element, and in a third configuration to couple the inlet port element and the outlet port element to one another.

Abstract: A manually operated flow control device has a frame with a first part and a second part connected to one another for relative motion alternately towards and away from one another along a line of action. A flow guide is connected to the frame, while a flow modification component is mounted to the frame and is operatively connected to the flow guide for changing a state of flow through the flow guide in accordance with relative positions of the first part and the second part along the line of action.

Abstract: A minimally invasive medical device comprises a tubular member with a large-diameter distal end portion and a smaller-diameter proximal portion. A clot-intake port is disposed in the distal end portion of the tubular member, while a cutter element is movably disposed in the distal end portion for severing material sucked in through the intake port and for temporarily closing the intake port during an extraction of the severed material from the device. A hollow drive rod extends through the tubular member to the cutter element for shifting the cutter element, while an outlet port is disposed in the tubular member proximally of the intake port and distally of the proximal portion of the tubular member. The tubular member extends through a catheter so that the intake port is disposed outside the catheter and the outlet port is disposed inside the catheter.

Abstract: An intravascularly deployable device in the nature of a filter for collecting intravascular debris includes a filter or collector body expandable from a collapsed insertion configuration to an expanded use configuration. The use configuration of the filter body tapers down from a maximum cross-sectional area to a minimal cross-sectional area at a downstream end of the filter body. The filter body is provided at the downstream end with an access port so that the instrument can traverse the access port to remove debris from the filter body after disposition of the intravascularly deployable device inside a blood vessel of a patient. The access port takes the form of a sleeve or chimney which is beveled to taper down from a maximal transverse dimension at an upstream end to a minimal transverse dimension at a downstream end.

Abstract: A pull push device for removing a clot. The device includes an elongate tubular member having a suction port and an irrigation or fluid pressurization port respectively connectable to a vacuum source and a pressurizable fluid reservoir. The tubular member also has a clot intake port positionable through a patient's skin inside a clogged vascular vessel. The vacuum source enables clot suction into the clot intake port for severing while liquid pressure supplies fluid for clot ejection and device clearance. A single piece rotating or reciprocating cutter and intake closure component is mounted inside the tubular member for closing the clot intake port upon each small vacuum assisted severing of clot mass by the cutting element. By simultaneously severing the clot and closing the intake port by the closure component, the device automatically converts from a suction to a pressure mode, thus ejecting any clot through the suction port.

Abstract: A cutting member for a medical material removal instrument comprises a cutting head having an axis and an elongate drive rod eccentrically attached at a distal end to the cutting head at a location spaced from the axis. The drive rod extends substantially parallel to the axis. The cutting member is used with an introducer sheath or catheter which has a distal end portion inserted into a patient. The cutting head is provided with a cut-out on the proximal side in part for enabling a drawing of material in a proximal direction internally from a patient into a distal end of the sheath upon a partial ejection of the cutting head from the distal end of the sheath during a material removal operation. The material drawn into the sheath is severed in a scissors-type action of the cutting head against the distal end of the sheath upon a drawing of the cutting head via the drive rod into the distal end of the sheath.

Abstract: A method for removing a clot utilizes a surgical instrument or device including an elongate tubular member having a most distal first opening, a relatively central second opening and a most proximal third opening all spaced from each other along the tubular member. The distal end of the tubular member is inserted through a skin surface of a patient into a subcutaneous blood vessel or vascular bypass and subsequently out of the vascular component and the skin surface so that the first opening and the third opening are located outside the patient while the second opening is located in the vascular component. Upon completed insertion of the device, suction is applied to one of the openings outside the patient to thereby draw a blood clot in the blood vessel or vascular bypass towards the second opening which is disposed in the vessel, graft or bypass.