Abstract: The invention provides compounds of formula (I): wherein the variables are defined in the specification, or a pharmaceutically-acceptable salt thereof, that are inhibitors of JAK kinases. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat inflammatory bowel diseases, and processes and intermediates useful for preparing such compounds.

Abstract: A method can include generating equipment specifications for a facility project at a field site by simulating physical phenomena using one or more computational simulators; using the equipment specifications and a computational facility planner system, generating a work breakdown structure for the facility project, where the work breakdown structure represents activities to be performed to deliver a defined scope of the facility project within a defined time; rendering a graphical user interface to a display that includes graphical controls for dependencies of the activities and equipment characterized by the equipment specifications; responsive to input received via one or more of the graphical controls, automatically updating at least durations of the activities; and, based at least in part on the updating, generating an optimal scenario for the facility project.

Abstract: An electrical component including a polymeric body which (i) defines at least one electrical connection; or (ii) is configured for attachment to an electrical cable or wire; or (iii) is configured for attachment to an electrical apparatus, wherein the polymeric body or a portion thereof includes a thermochromic composition which has a first colour condition below a first threshold temperature and a second colour condition if the composition is heated above the first threshold temperature, and wherein the thermochromic composition maintains the second colour condition until it is cooled below a second threshold temperature.

Abstract: An electrical component including a polymeric body which (i) defines at least one electrical connection; or (ii) is configured for attachment to an electrical cable or wire; or (iii) is configured for attachment to an electrical apparatus, wherein the polymeric body or a portion thereof includes a thermochromic composition which has a first colour condition below a first threshold temperature and a second colour condition if the composition is heated above the first threshold temperature, and wherein the thermochromic composition maintains the second colour condition until it is cooled below a second threshold temperature.