Patents by Inventor Gary A. Koolpe

Gary A. Koolpe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Metallocene compounds from amino alcohol-derived ligands
    Patent number: 6369253
    Abstract: A method is provided for synthesizing metallocene compounds useful as polymerization catalysts and the like. The method involves (a) preparation of an amino alcohol-derived ligand by reacting a silane reactant with an amino alcohol in the presence of base, followed by (b) metallation of the ligand so provided. The metallocenes may be provided in chiral form when the amino alcohol contains an asymmetric center, and are thus useful in catalyzing stereospecific polymerization and other stereospecific bond formation reactions.
    Type: Grant
    Filed: March 6, 2000
    Date of Patent: April 9, 2002
    Assignee: SRI International
    Inventors: Robert B. Wilson Jr., Gary A. Koolpe
  • Metallocene compounds from amino alcohol-derived ligands
    Patent number: 6048992
    Abstract: A method is provided for synthesizing metallocene compounds useful as polymerization catalysts and the like. The method involves (a) preparation of an amino alcohol-derived ligand by reacting a silane reactant with an amino alcohol in the presence of base, followed by (b) metallation of the ligand so provided. The metallocenes may be provided in chiral form when the amino alcohol contains an asymmetric center, and are thus useful in catalyzing stereospecific polymerization and other stereospecific bond formation reactions.
    Type: Grant
    Filed: March 25, 1999
    Date of Patent: April 11, 2000
    Assignee: SRI International
    Inventors: Robert B. Wilson, Jr., Gary A. Koolpe
  • Aldoxime-substituted imidazolium derivatives useful in the treatment of poisoning by phosphorus-containing chemicals
    Patent number: 4925856
    Abstract: A therapeutically effective class of low toxicity aldoxime-substituted functionalized imidazolium compounds and compositions is disclosed which is effective in the treatment of living species poisoned by organophosphorus chemicals which inactivate the enzyme acetylcholinesterase. In vivo administration of therapeutically effective amounts of these aldoxime-substituted imidazolium derivatives has been found to save mammals having inhibited acetylcholinesterase due to injection with lethal dosages of Soman.
    Type: Grant
    Filed: April 19, 1989
    Date of Patent: May 15, 1990
    Assignee: SRI International
    Inventors: Ralph N. Harris, III, Clifford D. Bedford, Dane A. Goff, Duane E. Hilmas, Robert A. Howd, Richard A. Kenley, Gary A. Koolpe, Robert O. Pick
  • Aldoxime-substituted triazolium compounds useful in the treatment of poisoning by phosphorus-containing chemicals
    Patent number: 4865837
    Abstract: A therapeutically effective class of low toxicity aldoxime-substituted trazolium derivatives is disclosed which is effective in the treatment of living species poisoned by organophosphorus chemicals which inactivate the enzyme acetylcholinesterase. In vivo administration of therapeutically effective amounts of these low toxicity aldoxime-substituted triazolium derivatives has been found to save mice having inhibited acetylcholinesterase due to injection with lethal dosages of Soman.
    Type: Grant
    Filed: July 28, 1987
    Date of Patent: September 12, 1989
    Assignee: SRI International
    Inventors: Ralph N. Harris, III, Clifford D. Bedford, Duane E. Hilmas, Robert A. Howd, Richard A. Kenley, Gary A. Koolpe