Patents by Inventor Gary A. Piazza

Gary A. Piazza has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for treating neoplasia with amino or pyridylamino cyclobutene derivatives
    Patent number: 6211220
    Abstract: A method for inhibiting neoplasia, particularly cancerous and precancerous lesions by exposing the affected cells to amino or pyridylamino cyclobutane derivatives.
    Type: Grant
    Filed: November 23, 1998
    Date of Patent: April 3, 2001
    Assignee: Cell Pathways, Inc.
    Inventors: Rifat Pamukcu, Gary A. Piazza
  • Method for treating neoplasia by exposure to substituted 2-aryl-benzimidazole derivatives
    Patent number: 6211177
    Abstract: A method for inhibiting neoplasia, particularly cancerous and precancerous lesions, by exposing the affected cells to substituted 2-aryl-benzimidazoles.
    Type: Grant
    Filed: November 24, 1998
    Date of Patent: April 3, 2001
    Assignee: Cell Pathways, Inc.
    Inventors: Gerhard Sperl, Ulrich Ixkes, Rifat Pamukcu, Gary A. Piazza
  • Method for treating a patient having precancerous lesion with 4-phenylphthalazine derivatives
    Patent number: 6207666
    Abstract: Derivatives of 4-phenylphthalazine are useful for the treatment of patients having precancerous lesions. These compounds are also useful to inhibit the growth of neoplastic cells.
    Type: Grant
    Filed: April 23, 1998
    Date of Patent: March 27, 2001
    Assignee: Cell Pathways, Inc.
    Inventors: Gary Piazza, Rifat Pamukcu
  • Method of treating a patient having precancerous lesions with phenyl purinone derivatives
    Patent number: 6200980
    Abstract: Derivatives of Phenyl Purinone are useful for the treatment of patients having precancerous lesions. These compounds are also useful to inhibit growth of neoplastic cells.
    Type: Grant
    Filed: April 17, 1997
    Date of Patent: March 13, 2001
    Assignee: Cell Pathways, Inc.
    Inventors: Gary A. Piazza, Rifat Pamukcu
  • Method of using a novel phosphodiesterase in pharmaceutical screeing to identify compounds for treatment of neoplasia
    Patent number: 6200771
    Abstract: A method for identifying compounds useful for the treatment of neoplasia involves acertaining whether such compounds exhibit an ability to inhibit a PDE that is characterized by cGMP specificity, cooperative kinetic behavior and insensitivity to phosphorylation.
    Type: Grant
    Filed: October 15, 1998
    Date of Patent: March 13, 2001
    Assignee: Cell Pathways, Inc.
    Inventors: Li Liu, Rifat Pamukcu, W. Joseph Thompson, Gary A. Piazza, Han Li, Bing Zhu
  • Method for inhibiting neoplastic cells and related conditions by exposure to 2,8-disubstituted quinazoline derivatives
    Patent number: 6187779
    Abstract: A method for inhibiting neoplastic cells and related conditions by exposing them to 2,8 disubstituted quinazolinone compounds.
    Type: Grant
    Filed: November 20, 1998
    Date of Patent: February 13, 2001
    Assignee: Cell Pathways, Inc.
    Inventors: Rifat Pamukcu, Gary A. Piazza
  • [4,5]-Fused-1,3-disubstituted-1,2-diazine-6-one derivatives with nitrogen containing substitutents in position one for the treatment of neoplasia
    Patent number: 6180629
    Abstract: [4,5]-Fused-1,3-disubstituted-1,2-diazine-6-one derivatives with nitrogen-containing substituents in position one are useful for inducing or promoting apoptosis and for arresting uncontrolled neoplastic cell proliferation, and are specifically useful in the arresting and treatment of neoplasia, including precancerous and cancerous lesions.
    Type: Grant
    Filed: August 14, 1998
    Date of Patent: January 30, 2001
    Assignee: Cell Pathways, Inc.
    Inventors: Xiaojing Wang, Gerhard Sperl, Paul Gross, Rifat Pamukcu, Gary A. Piazza
  • Substituted condensation products of N-benzyl-3-idenylacetamides with heterocyclic aldehydes for neoplasia
    Patent number: 6166053
    Abstract: Substituted condensation products of N-benzyl-3-indenylacetamides with heterocyclic aldehydes are useful for inducing or promoting apotosis and for arresting uncontrolled neoplastic cell proliferation, and are specifically useful in the arresting and treatment of neoplasias, including precancerous and cancerous lesions.
    Type: Grant
    Filed: January 24, 2000
    Date of Patent: December 26, 2000
    Assignee: Cell Pathways, Inc.
    Inventors: Gerhard J. Sperl, Paul Gross, Klaus Brendel, Gary A. Piazza, Rifat Pamukcu
  • Methods for using a phosphodiesterase in pharmaceutical screening to identify compounds for treatment of neoplasia
    Patent number: 6156528
    Abstract: This invention provides a method to identify compounds potentially useful for the treatment of neoplasia in mammals. The phosphodiesterase inhibitory activity of a compound is determined along with COX inhibitory activity. Growth inhibitory and apoptosis inducing effects on cultured tumor cells are also determined. Compounds that exhibit phosphodiesterase inhibiton, growth inhibition and apoptosis induction, but not substantial prostaglandin inhibitory activity, are desirable for the treatment of neoplasia.
    Type: Grant
    Filed: December 19, 1998
    Date of Patent: December 5, 2000
    Assignee: Cell Pathways, Inc
    Inventors: Rifat Pamukcu, Gary A. Piazza
  • Method for inhibiting neoplastic cells and related conditions by exposure thienopyrimidine derivatives
    Patent number: 6133271
    Abstract: Benzothienopyrimidine derivatives for inducing or promoting apoptosis and for arresting uncontrolled neoplastic cell proliferation, and specifically for arresting and treating neoplasia, including precancerous and cancerous lesions of formula I: ##STR1## wherein R.sub.1 and R.sub.2 are independently selected from the group consisting of hydrogen, A, OA, alkenyl, alkynyl, --NO.sub.2, --CF.sub.3 or halogen, with the proviso that one of R.sub.1 or R.sub.2 is not hydrogen; R.sub.3 and R.sub.4 are independently selected from the group consisting of hydrogen, A, --OA, halogen, --NO.sub.2, --NH.sub.2, --NHA or --NAA', or R.sub.3 and R.sub.4 are together form a moiety selected from the group consisting of --O--CH.sub.2 --CH.sub.2 --, --O--CH.sub.2 --O-- or --O--CH.sub.2 --CH.sub.
    Type: Grant
    Filed: November 19, 1998
    Date of Patent: October 17, 2000
    Assignee: Cell Pathways, Inc.
    Inventors: Rifat Pamukcu, Gary A. Piazza
  • Method for inhibiting neoplastic cells and related conditions by exposure to 9-substituted 2-(2-N-aloxyphenyl) purin-6-ones
    Patent number: 6124303
    Abstract: A method for inhibiting neoplastic cells and related conditions by exposing them to 9-substituted 2-(2-n-alkoxyphenyl)purin-6-one compounds.
    Type: Grant
    Filed: September 11, 1998
    Date of Patent: September 26, 2000
    Assignee: Cell Pathways, Inc.
    Inventors: Rifat Pamukcu, Gary A. Piazza
  • Substituted methoxy benzylidene indenyl acetic and propionic acids for treating patients with precancerous lesions
    Patent number: 6121321
    Abstract: Substituted methoxy benzylidene indenyl compounds are useful in the treatment of precancerous lesions and neoplasms.
    Type: Grant
    Filed: June 13, 1996
    Date of Patent: September 19, 2000
    Assignees: Cell Pathways, Inc., University of Arizona
    Inventors: Gerhard Sperl, Paul Gross, Klaus Brendel, Gary A. Piazza, Rifat Pamukcu
  • Method of inhibiting neoplastic cells with pyrazolopyridylpyridazinone derivatives
    Patent number: 6077842
    Abstract: A method for inhibiting neoplasia, particularly cancerous and precancerous lesions by exposing the affected cells to pyrazolopyridylpyridazinone derivatives.
    Type: Grant
    Filed: November 24, 1998
    Date of Patent: June 20, 2000
    Assignee: Cell Pathways, Inc.
    Inventors: Rifat Pamukcu, Gary A. Piazza
  • Indenyl hydroxamic acids, (hydroxy) ureas and urethanes for treating patients with precancerous lesions
    Patent number: 6071934
    Abstract: Indenyl hydroxamic acids, (hydroxy) ureas and urethanes are useful in the treatment of precancerous lesions and neoplasms.
    Type: Grant
    Filed: March 25, 1997
    Date of Patent: June 6, 2000
    Assignee: Cell Pathways, Inc.
    Inventors: Gerhard Sperl, Paul Gross, Rifat Pamukcu, Klaus Brendel, Gary A. Piazza
  • Substituted condensation products of N-benzyl-3-indenylacetamides heterocyclic aldehydes for neoplasia
    Patent number: 6066634
    Abstract: Substituted condensation products of N-benzyl-3-indenylacetamides with heterocyclic aldehydes are useful for inducing or promoting apotosis and for arresting uncontrolled neoplastic cell proliferation, and are specifically useful in the arresting and treatment of neoplasias, including precancerous and cancerous lesions.
    Type: Grant
    Filed: December 7, 1998
    Date of Patent: May 23, 2000
    Assignees: Cell Pathways, Inc., University of Arizona
    Inventors: Gerhard J. Sperl, Paul Gross, Klaus Brendel, Gary A. Piazza, Rifat Pamukcu
  • Substituted benzylidene indenyl formamides, acetamides and propionamides
    Patent number: 6063818
    Abstract: Substituted benzylidene indenyl formamides, acetamides and propionamides are useful in the treatment of precancerous lesions and neoplasms.
    Type: Grant
    Filed: June 3, 1997
    Date of Patent: May 16, 2000
    Assignee: Cell Pathways Inc.
    Inventors: Gerhard Sperl, Paul Gross, Klaus Brendel, Rifat Pamukcu, Gary A. Piazza
  • Method of treating a patient having precancerous lesions with phenyl cycloamino pyrimidinone derivatives
    Patent number: 6060477
    Abstract: Derivatives of Phenyl Cycloamino Pyrimidinone are useful for the treatment of patients having precancerous lesions. These compounds are also useful to inhibit growth of neoplastic cells.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: May 9, 2000
    Assignee: Cell Pathways, Inc.
    Inventors: Gary A. Piazza, Rifat Pamukcu
  • Method of treating a patient having a precancerous lesions with amide quinazoline derivatives
    Patent number: 6046206
    Abstract: Derivatives of quinazoline are useful for the treatment of patients having precancerous lesions. These compounds are also useful to inhibit the growth of neoplastic cells.
    Type: Grant
    Filed: April 30, 1997
    Date of Patent: April 4, 2000
    Assignee: Cell Pathways, Inc.
    Inventors: Rifat Pamukcu, Gary Piazza
  • Method of inhibiting neoplastic cells with tetracyclic pyrido[3,4-B]indole derivatives
    Patent number: 6046199
    Abstract: A method for inhibiting neoplastic, particularly cancerous and precancerous lesions by exposing the affected cells to pyrido[3,4b]indoles.
    Type: Grant
    Filed: January 14, 1998
    Date of Patent: April 4, 2000
    Assignee: Cell Pathways, Inc.
    Inventors: Rifat Pamukcu, Gary A. Piazza
  • Method of treating a patient having precancerous lesions with phenyl pyridinone derivatives
    Patent number: 6046216
    Abstract: Derivatives of phenyl pyridinone are useful for the treatment of patients having precancerous lesions. These compounds are also useful to inhibit the growth of neoplastic cells.
    Type: Grant
    Filed: April 1, 1997
    Date of Patent: April 4, 2000
    Assignee: Cell Pathways, Inc.
    Inventors: Gary Piazza, Rifat Pamukcu