Abstract: Equipment for forming a tubular rod of fibrous material comprises: a gathering station constructed to receive a continuous supply of fibres and to gather the fibres into a bundle as the fibres advance through the equipment; a divider arranged in the path of the fibres through the equipment and constructed to from a cleft along the length of the bundle as it advances through the equipment; a mandrel positioned in the path of the bundle of fibres in alignment with the divider and constructed to form the cleft into a passage through the bundle of fibres as the bundle of fibres advances over the mandrel; and a die constructed and arranged to cooperate with the mandrel to form the fibres in a tubular configuration around the mandrel.

Abstract: The invention relates generally to antibodies, activatable antibodies, multispecific antibodies, and multispecific activatable antibodies that specifically bind to at least CD3, as well as to methods of making and using these antibodies, activatable antibodies, multispecific antibodies, and/or multispecific activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.

Abstract: An intraocular lens (IOL) injector cartridge having one or more modifications from conventional designs which reduce stress and strain in the optic of the IOL during passage through the cartridge. One change includes adding axially-oriented ribs in a funnel portion of the cartridge to enable the cartridge wall to flex outward during passage of the IOL, which is compressed to a great degree in the cartridge lumen. Another modification involves providing a longitudinal step along a segment of the inner lumen which biases one free edge of the optic to tuck or dive under the other free edge and encourage spiral folding as the IOL progresses along the gradually narrowing lumen. The third option is modifying the shape of the lumen within the extreme distal end of the cartridge where the lumen is smallest so that it is neither circular nor oval. Each or all of these modifications may be incorporated into a single cartridge.

Abstract: A method of operating an Internet of Things (IoT) device, the IoT device capable of communicating with a third-party system in order to perform an autonomous task subject to authorisation by an IoT authorisation device, the method comprising: sending operating parameters relating to the autonomous task to a user for approval; receiving user-approved operating parameters for the autonomous task; configuring the IoT device to perform the autonomous task within the user approved operating parameters; registering the user approved operating parameters with the IoT device management server to enable the IoT authorisation device to check that the IoT device is operating within the user-approved operating parameters when it performs an autonomous task with the third-party system.

Abstract: The present disclose provides systems and methods relating to monitoring facility equipment at disparate locations using a host system accessible to approved devices connected to an enterprise network, as well as understanding an availability and reliability of the equipment.

Abstract: Ophthalmic lenses are described herein. An example ophthalmic lens may comprise a first surface. The example ophthalmic lens may comprise a second surface disposed opposite the first surface. The second surface may be configured to abut at least a portion of an eye of a wearer. The example ophthalmic lens may comprise a lens stabilization zone disposed adjacent the first surface. At least a contour of the lens stabilization zone may be configured to minimize a recovery time for the ophthalmic lens to orient to a resting position from a misaligned position.

Abstract: The invention provides an improved rotationally stabilized contact lens design and method of designing such a lens which minimizes stabilization time of the lens while maximizing the lens on-eye comfort. The lens and the method of designing the lens further improves upon an earlier method which utilizes and combines non-circularity and thickness differential aspects which results in equivalent or minimized stabilization time, ease of insertion and manufacturability as well as maximum comfort that is improved over that of what either aspect can achieve independently. This further improvement of stiffness profile is achieved by optimizing and selectively addressing thickness differential both diametrically and circumferentially in a non-round lens design.

Abstract: Ophthalmic lenses are described herein. An example ophthalmic lens may comprise a first surface. The example ophthalmic lens may comprise a second surface disposed opposite the first surface. The second surface may be configured to abut at least a portion of an eye of a wearer. The example ophthalmic lens may comprise a lens stabilization zone disposed adjacent the first surface. At least a contour of the lens stabilization zone may be configured to minimize a recovery time for the ophthalmic lens to orient to a resting position from a misaligned position.

Abstract: Acquiring and evaluating data regarding the performance of critical equipment of various business units distributed around the globe is essential in today's market. In particular aggregating, organizing and evaluating various types of data at a host processing system that is accessible via an intuitive graphical user interface to approved users connected to an enterprise network.

Abstract: Acquiring and evaluating data regarding the performance of critical equipment of various business units distributed around the globe is essential in today's market. In particular aggregating, organizing and evaluating various types of data at a host processing system that is accessible via an intuitive graphical user interface to approved users connected to an enterprise network.

Abstract: Ophthalmic lenses are described herein. An example ophthalmic lens may comprise a first surface. The example ophthalmic lens may comprise a second surface disposed opposite the first surface. The second surface may be configured to abut at least a portion of an eye of a wearer. The example ophthalmic lens may comprise a lens stabilization zone disposed adjacent the first surface. At least a contour of the lens stabilization zone may be configured to minimize a recovery time for the ophthalmic lens to orient to a resting position from a misaligned position.

Abstract: The invention provides an improved rotationally stabilized contact lens design and method of designing such a lens which minimizes stabilization time of the lens while maximizing the lens on-eye comfort. The lens and the method of designing the lens further improves upon an earlier method which utilizes and combines non-circularity and thickness differential aspects which results in equivalent or minimized stabilization time, ease of insertion and manufacturability as well as maximum comfort that is improved over that of what either aspect can achieve independently. This further improvement of stiffness profile is achieved by optimizing and selectively addressing thickness differential both diametrically and circumferentially in a non-round lens design.

Abstract: A dose control mechanism for a syringe includes an engaging screw thread arrangement between an exterior surface of a plunger and a longitudinally extending channel of a housing. The engaging screw thread arrangement includes at least one thread segment and a pitch guide including a variable pitch thread. At least a portion of the longitudinally extending channel of the housing including one of the pitch guide and the at least one thread segment, and the plunger includes the other of the pitch guide and the at least one thread segment. The plunger resides at least partially within the housing with the at least one thread segment engaged with the pitch guide. An accurate dose drug delivery syringe includes such a dose control mechanism, a barrel, a plunger seal, and a barrel adapter assembly having a barrel tip and a needle.

Abstract: Acquiring and evaluating data regarding the performance of critical equipment of various business units distributed around the globe is essential in today's market. In particular aggregating, organizing and evaluating various types of data at a host processing system that is accessible via an intuitive graphical user interface to approved users connected to an enterprise network.

Abstract: A dose control mechanism for a syringe includes an engaging screw thread arrangement between an exterior surface of a plunger and a longitudinally extending channel of a housing. The engaging screw thread arrangement includes at least one thread segment and a pitch guide including a variable pitch thread. At least a portion of the longitudinally extending channel of the housing including one of the pitch guide and the at least one thread segment, and the plunger includes the other of the pitch guide and the at least one thread segment. The plunger resides at least partially within the housing with the at least one thread segment engaged with the pitch guide. An accurate dose drug delivery syringe includes such a dose control mechanism, a barrel, a plunger seal, and a barrel adapter assembly having a barrel tip and a needle.

Abstract: A method of determining availability and reliability of facility equipment. The method includes monitoring an operational status of a piece of equipment of a facility. The method also includes outputting a visual display illustrating the operational status of the equipment, wherein the operational status is categorized into a plurality of categories, at least one of the plurality of categories requiring an operator to classify an interruption of function of the equipment as one of a planned outage, a forced outage, and a standby mode. The method further includes calculating a reliability percentage of the equipment based on a total amount of time classified as the forced outage. The method yet further includes calculating an availability percentage of the equipment based on a total amount of time classified as the forced outage and the planned outage.

Abstract: A method of folding a multiple element IOL comprising folding the first lens element and second lens element such that the second lens element at least partially surrounds the first lens element and such that, after folding, both the first lens element and the second lens element are substantially aligned along the optical axis. A hinged apparatus such as a cartridge may be used to cause the second lens element to be folded. A method of loading a multielement IOL comprising folding the haptics such that a portion of the haptics contacts an exterior side of one of the first lens element and the second lens element.

Abstract: A scleral prosthesis includes an elongated body that is narrower in a middle and wider at opposing first and second ends. The body includes multiple first portions that form the first end of the body, where the first portions separated lengthwise along the body. The first portions are biased to maintain separation without external interference but are configured to be pushed towards each other in order to narrow a width of the first end. The body could also include second portions that form the second end of the body. The body could further include a cavity configured to receive a material and an eluting surface configured to release the material from the cavity. In addition, the body could include a cavity configured to receive a material and a protrusion that extends away from the scleral prosthesis, where the protrusion is configured to release the material from the cavity.

Abstract: A multi-element accommodating intraocular lens (AIOL) having a first anterior translation member and a first posterior translation member coupled together to form a first bias element. The first posterior translation member has a greater resistance to bending than the first anterior translation member. The first posterior translation member has a greater thickness than the first anterior translation member.