Patents by Inventor Gary A. Rotert

Gary A. Rotert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Radioligands and their use for identifying potassium channel modulators
    Patent number: 6632418
    Abstract: The present invention relates to novel radioligands and test methods using those radioligands in screening compounds.
    Type: Grant
    Filed: July 30, 2002
    Date of Patent: October 14, 2003
    Assignee: Abbott Laboratories
    Inventors: Robert J. Altenbach, Gary A. Rotert, William A. Carroll, Murali Gopalakrishnan, Eduardo Jose Vicente Molinari, Rachel A. Davis-Taber, Victoria Eleanor Sarah Scott
  • Novel radioligands and their use for identifying potassium channel modulators
    Publication number: 20030065182
    Abstract: The present invention relates to novel radioligands and test methods using those radioligands in screening compounds.
    Type: Application
    Filed: July 30, 2002
    Publication date: April 3, 2003
    Inventors: Robert J. Altenbach, Gary A. Rotert, William A. Carroll, Murali Gopalakrishnan, Eduardo Jose Vicente Molinari, Rachel A. Davis-Taber, Victoria Eleanor Sarah Scott
  • Iodinated estradiols, intermediate products and methods of production
    Patent number: 4855125
    Abstract: A method of preparation of estradiol derivatives labeled by iodine, especially .sup.123 I, substitution at C-16 are synthesized according to the present invention. A triflate intermediate is prepared from which either 16-alpha-.sup.123 I-17-beta-estradiol or 16-beta-.sup.123 I-17-beta-estradiol are prepared by described methods. Both 16-alpha-.sup.123 I- and 16-beta-.sup.123 I-17-beta-estradiol made according to the methods described herein have a high relative specific acitvity. The methods are sufficiently rapid so that the relatively short half-life of .sup.123 I is readily accommodated without substantial radioactive decay of the label.
    Type: Grant
    Filed: September 25, 1987
    Date of Patent: August 8, 1989
    Assignee: Bio-Medical Research Laboratories
    Inventors: Richard J. Baranczuk, Jay Spicer, William P. Duncan, Gary A. Rotert
  • Halogen labeled compounds including estradiol derivatives, their synthetic intermediates and the syntheses thereof
    Patent number: 4659517
    Abstract: A method of preparation of halogen labeled organic compounds is described. In particular, estradiol derivatives labeled by halogen substitution at C-16 are synthesized according to the present invention. A triflate intermediate is prepared from which either 16-alpha-halo-substituted-17-beta-estradiols or 16-beta-halo-substituted-17-beta-estradiols can be rapidly formed as desired. In particular, the preparation of 16-alpha-.sup.123 I-17-beta-estradiol and 16-beta-.sup.123 I-17-beta-estradiol are shown and are synthesized from a 17-beta-estradiol-16-beta-triflate. Both 16-alpha-.sup.123 I- and 16-beta-.sup.123 I-17-beta-estradiol made according to the present invention are shown to have a high specific activity. The method of synthesis is sufficiently rapid so that the relatively short half-life of .sup.123 I is readily accommodated. The high stereospecificity of each step of the reaction sequence in preparing the labeled estradiols provides for highly efficient syntheses and little waste of radio-label.
    Type: Grant
    Filed: October 22, 1984
    Date of Patent: April 21, 1987
    Assignee: Bio-Medical Research Laboratories, Inc.
    Inventors: Jay Spicer, William P. Duncan, Gary A. Rotert