Abstract: The disclosure is directed in part to extended release compositions that include hydroxy progesterone caproate. For example, provided herein is a therapeutic microparticle composition comprising a plurality of microparticles, wherein the microparticles each comprise poly (lactide-co-glycolide) and hydroxyprogesterone caproate.

Abstract: The present invention relates to emulsion and double-emulsion based processes for preparing microparticles. The invention also relates to workhead assemblies for in-line flow-through mixing devices that can be used for mixing two or more fluids. The workhead assemblies can be used with the processes for preparing microparticles.

Abstract: The described invention provides a biodegradable, biocompatible delivery system of flowable sustained release microparticulate composition of a substantially pure crystalline form of a bioactive agent such as, for example, nimodipine, a process of preparing a therapeutic form of a substantially pure crystalline form of the bioactive agent and a method for treating an interruption of a cerebral artery in a subarachnoid space at risk of interruption caused by brain injury in a mammal, which reduces signs or symptoms of at least one delayed complication associated with brain injury.

Abstract: In accordance with an exemplary embodiment, a method for repairing a damaged metallic component using additive manufacturing techniques includes separating a damaged portion of the damaged metallic component from an undamaged portion of the damaged metallic component, measuring the undamaged portion to determine the dimensions of the removed damaged portion, fabricating a replacement portion using additive manufacturing techniques in accordance with the determined dimensions of the removed damaged portion, and joining the replacement portion with the undamaged portion of the damaged metallic component to form a repaired metallic component.

Abstract: In accordance with an exemplary embodiment, a method for repairing a damaged metallic component using additive manufacturing techniques includes separating a damaged portion of the damaged metallic component from an undamaged portion of the damaged metallic component, measuring the undamaged portion to determine the dimensions of the removed damaged portion, fabricating a replacement portion using additive manufacturing techniques in accordance with the determined dimensions of the removed damaged portion, and joining the replacement portion with the undamaged portion of the damaged metallic component to form a repaired metallic component.

Abstract: The described invention provides a biodegradable, biocompatible delivery system of flowable sustained release microparticulate composition of a substantially pure crystalline form of a bioactive agent such as, for example, nimodipine, a process of preparing a therapeutic form of a substantially pure crystalline form of the bioactive agent and a method for treating an interruption of a cerebral artery in a subarachnoid space at risk of interruption caused by brain injury in a mammal, which reduces signs or symptoms of at least one delayed complication associated with brain injury.

Abstract: The described invention provides a biodegradable, biocompatible delivery system of flowable sustained release microparticulate composition of a substantially pure crystalline form of a bioactive agent such as, for example, nimodipine, a process of preparing a therapeutic form of a substantially pure crystalline form of the bioactive agent and a method for treating an interruption of a cerebral artery in a subarachnoid space at risk of interruption caused by brain injury in a mammal, which reduces signs or symptoms of at least one delayed complication associated with brain injury.

Abstract: The described invention provides a biodegradable, biocompatible delivery system of flowable sustained release microparticulate composition of a substantially pure crystalline form of a bioactive agent such as, for example, nimodipine, a process of preparing a therapeutic form of a substantially pure crystalline form of the bioactive agent and a method for treating an interruption of a cerebral artery in a subarachnoid space at risk of interruption caused by brain injury in a mammal, which reduces signs or symptoms of at least one delayed complication associated with brain injury.

Abstract: Disclosed herein are systems and methods useful for delivery of suspensions and other microparticle compositions, and, in particular, for delivering microparticles at desired dosing levels and eliminating blockages within microparticle suspensions positioned within a delivery device.

Abstract: The present invention relates to emulsion and double-emulsion based processes for preparing microparticles. The invention also relates to workhead assemblies for in-line flow-through mixing devices that can be used for mixing two or more fluids. The workhead assemblies can be used with the processes for preparing microparticles.

Abstract: A 3-D adaptive laser powder fusion welding system provides for both modeling/gauging of a workpiece as well as repair, restoration, and/or manufacture thereof. By providing a work platform and apparatus support system, five degrees of control in the form of two linear axes and three rotational axes are provided. The sixth linear axis is controlled via the displacement of a laser powder fusion (LPF) welding head and a laser rangefinding head. The laser rangefinding head system enables the workpiece W to be modeled electronically or otherwise. Additionally, the rangefinding system enables a model part to serve as a template from which repairs or construction are affected. The LPF welding head then affects any repairs or manufacture that are needed on the workpiece W. The LPF welding head is powered by filler material. The entire system is generally controlled by computer which enable the operator to be separated from a generally hot and hostile welding environment.

Abstract: A novel and inventive hand held powder-fed laser fusion welding torch providing manual flexibility for laser welding with powder-fed material. The hand held laser includes a body, handle, and nozzle assembly. The nozzle may be shrouded by a cover that is slightly spaced apart from the nozzle. The gap between the two may provide space through which inert gas may flow. Laser light from a remote source shines through the nozzle's central aperture. The nozzle aperture may be circumscribed by powder channel outlets aligned upon a working focal point coincident with the laser beam to treat a workpiece. A proximity sensor may enable selective welding torch operation according to the presence of a workpiece.

Abstract: A novel and inventive hand held powder-fed laser fusion welding torch providing manual flexibility for laser welding with powder-fed material. The hand held laser includes a body, handle, and nozzle assembly. The nozzle may be shrouded by a cover that is slightly spaced apart from the nozzle. The gap between the two may provide space through which inert gas may flow. Laser light from a remote source shines through the nozzle's central aperture. The nozzle aperture may be circumscribed by powder channel outlets aligned upon a working focal point coincident with the laser beam to treat a workpiece. A proximity sensor may enable selective welding torch operation according to the presence of a workpiece.

Abstract: A novel and inventive hand held powder-fed laser fusion welding torch providing manual flexibility for laser welding with powder-fed material. The hand held laser includes a body, handle, and nozzle assembly. The nozzle may be shrouded by a cover that is slightly spaced apart from the nozzle. The gap between the two may provide space through which inert gas may flow. Laser light from a remote source shines through the nozzle's central aperture. The nozzle aperture may be circumscribed by powder channel outlets aligned upon a working focal point coincident with the laser beam to treat a workpiece. A proximity sensor may enable selective welding torch operation according to the presence of a workpiece.

Abstract: A novel and inventive hand held powder-fed laser fusion welding torch providing manual flexibility for laser welding with powder-fed material. The hand held laser includes a body, handle, and nozzle assembly. The nozzle may be shrouded by a cover that is slightly spaced apart from the nozzle. The gap between the two may provide space through which inert gas may flow. Laser light from a remote source shines through the nozzle's central aperture. The nozzle aperture may be circumscribed by powder channel outlets aligned upon a working focal point coincident with the laser beam to treat a workpiece. A proximity sensor may enable selective welding torch operation according to the presence of a workpiece.

Abstract: A method of treating or preventing an intracellular infection in an animal comprising administering a first effective amount of a suitable drug contained in first biocompatible microspheres that have a diameter of less than or equal to about 10 microns, wherein the first microspheres release the suitable drug upon administration at a first effective rate. A second set of microspheres greater than 10 microns in diameter may also be administered to provide continuing systemic release of the drug.