Patents by Inventor Gary Abrams

Gary Abrams has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GENE THERAPY COMPOSITIONS AND METHODS FOR TREATING DISEASES OF THE RETINA
    Publication number: 20250387513
    Abstract: The present invention provides recombinant AAV particles comprising an opsin transgene for therapy of retinal diseases, and related compositions and methods.
    Type: Application
    Filed: August 15, 2025
    Publication date: December 25, 2025
    Applicants: Ray Therapeutics, Inc., Wayne State University
    Inventors: Peter Francis, Zhuo-Hua Pan, Paul Bresge, Gary Abrams, Qi Lu
  • IDENTIFICATION OF MUTATIONS IN CHANNELOPSIN VARIANTS HAVING IMPROVED LIGHT SENSITIVITY AND METHODS OF USE THEREOF
    Publication number: 20250163111
    Abstract: The invention provides compositions and kits including at least one nucleic acid or polypeptide molecule encoding for a mutant CoChop protein. Methods of the invention include administering a composition comprising a mutant CoChop to a subject to preserve, improve, or restore phototransduction. Preferably, the compositions and methods of the invention are provided to a subject having impaired vision, thereby restoring vision to normal levels.
    Type: Application
    Filed: January 16, 2025
    Publication date: May 22, 2025
    Inventors: Zhuo-Hua Pan, Tushar Ganjawala, Qi Lu, Gary Abrams
  • Identification of mutations in channelopsin variants having improved light sensitivity and methods of use thereof
    Patent number: 12234267
    Abstract: The invention provides compositions and kits including at least one nucleic acid or polypeptide molecule encoding for a mutant CoChop protein. Methods of the invention include administering a composition comprising a mutant CoChop to a subject to preserve, improve, or restore phototransduction. Preferably, the compositions and methods of the invention are provided to a subject having impaired vision, thereby restoring vision to normal levels.
    Type: Grant
    Filed: May 19, 2021
    Date of Patent: February 25, 2025
    Assignee: Wayne State University
    Inventors: Zhuo-Hua Pan, Tushar Ganjawala, Qi Lu, Gary Abrams
  • METHOD OF ENHANCING VIRAL-MEDIATED GENE DELIVERY
    Publication number: 20200368332
    Abstract: The invention provides methods for enhancing the delivery of viral vectors to the eye of a subject by administering a proteasome inhibitor or and a viral vector ending a gene of interest to the eye.
    Type: Application
    Filed: January 31, 2020
    Publication date: November 26, 2020
    Inventors: Zhuo-Hua PAN, Shengjie CUI, Gary ABRAMS
  • METHOD OF ENHANCING VIRAL-MEDIATED GENE DELIVERY
    Publication number: 20170319669
    Abstract: The invention provides methods for enhancing the delivery of viral vectors to the eye of a subject by administering a proteasome inhibitor or and a viral vector ending a gene of interest to the eye.
    Type: Application
    Filed: May 3, 2017
    Publication date: November 9, 2017
    Inventors: Zhuo-Hua PAN, Shengjie CUI, Gary ABRAMS
  • Enhanced Iron Sights
    Publication number: 20150345902
    Abstract: A firearm such as a pistol, which uses “iron sights”. The forward sight element is secured to a forward portion of the pistol and has a generally rectangular cross section. The rear sight has a left element and a right element, both of which are secured to the pistol at a rearward portion of the firearm. To assist the user in sighting when the forward sight may appear larger than the gap between the rear sight elements, the rear sight elements each have a profile in which they are narrower at a base near the pistol than at the sighting gap distal from the pistol.
    Type: Application
    Filed: May 30, 2014
    Publication date: December 3, 2015
    Inventors: Gary Abrams, Carl Welch