Abstract: The present disclosure provides inhibitors of Janus Kinase 2 (JAK2) which may be used in the treatment of medical disorders such as cancer.

Abstract: Membranes and filtration modules for producing a concentrated feed stream and a diluted feed stream during operation in a water purification or wastewater treatment system. Filtration modules are provided that include a semipermeable membrane having a first side and a second side, the first side configured to receive a first feed solution stream from a first feed solution source and the second side configured to receive a second feed solution stream from a second feed solution source. The semipermeable membrane may be configured to operate at a hydrostatic pressure on the second side of the membrane from about 1% to about 40% of the hydrostatic pressure on the first side of the membrane, and may in some cases exhibit a salt rejection of from about 60 percent to about 90 percent during operation.

Abstract: An adaptive container loading assembly is provided and includes a container forming assembly and a container shuttle assembly. The container forming provides a plurality of varying sized containers. The container shuttle assembly is positioned adjacent to the container forming assembly and includes a linear synchronous motor guideway shaped in an endless loop, and a plurality of transport vehicles moveable about the guideway, each transport vehicle a leading shuttle and a trailing shuttle spaced apart by a determined distance to accommodate and receive the plurality of varying sized containers.

Abstract: A system for flow-count includes one or more cameras and a processing system. The one more cameras are configured to capture image data comprising a sequence of frames. The processing system is configured to extract spatial features and temporal features based on the sequence of frames; construct, based on the spatial features and temporal features, a density map and/or a flow map corresponding to a frame of the sequence of frames, wherein the density map comprises density values for the plurality of pixels, wherein the flow map comprises two-dimensional (2D) vectors for the plurality of pixels, and wherein a 2D vector indicates a speed and direction for a pixel of the plurality of pixels in the frame; and determine, based on the density map and/or the flow map, a count, a distribution, and/or movement of objects corresponding to the frame.

Abstract: Dynamic data quantization may be applied to minimize the power consumption of a system that implements a convolutional neural network (CNN). Under such a quantization scheme, a quantized representation of a 3×3 array of m-bit activation values may include 9 n-bit mantissa values and one exponent shared between the n-bit mantissa values (n<m); and a quantized representation of a 3×3 kernel with p-bit parameter values may include 9 q-bit mantissa values and one exponent shared between the q-bit mantissa values (q<p). Convolution of the kernel with the activation data may include computing a dot product of the 9 n-bit mantissa values with the 9 q-bit mantissa values, and summing the shared exponents. In a CNN with multiple kernels, multiple computing units (each corresponding to one of the kernels) may receive the quantized representation of the 3×3 array of m-bit activation values from the same quantization-alignment module.

Abstract: Semiconductor devices with a conformal coating in contact with a ground plane at a bottom side of the semiconductor devices and associated systems and methods are disclosed herein. In one embodiment, a semiconductor device includes a semiconductor die coupled to a first surface of a package substrate. The semiconductor device can also include a molded material covering at least a portion of the package substrate and the semiconductor die. The semiconductor device can also include a ground plane in the package substrate and exposed through an opening in a second surface of the package substrate opposite the first surface. The semiconductor device can also include a conformal coating coupled to the ground plane through the opening that can shield the semiconductor device from electromagnetic interference.

Abstract: A method for homing a stepping motor having a plurality of full-step positions within each full rotation of a rotor of the stepper motor includes applying a first drive current to windings of the stepper motor to rotate the rotor at least one full rotation in a first direction away from an end-of-travel (EOT) position. Thereafter, the drive current is applied to the windings to rotate the rotor in a second direction toward the EOT position. Upon detection of EOT, the drive current is discontinued. Drive current is then applied to the windings to rotate the rotor of the stepper motor in micro-steps in the first direction to a closest full-step position of the stepper motor. Finally, a drive current is applied to drive the stepper motor a predetermined number of full steps away from the EOT position.

Abstract: A body support structure includes a base, a seat and a backrest, with the backrest connected to the base with a torsion leaf spring. The torsion leaf spring may be configured with a plurality of fingers, and/or one or more flex regions. One or more struts may be connected between the seat or backrest and the base. In another aspect, the seat and/or backrest may be supported with one or more links that provide a counter-intuitive motion. In another aspect, a link may be coupled to a support with a flexible blade.

Abstract: System and methods are provided for effecting user experience in an electronic game environment through use of virtual currency or vCoins. In a multi-level game, the systems and methods include memory for storing information on game play, the information including input received from the user, information relating to levels within the multi-level game and game display information for output to the user. A processor is coupled to the memory for generating game play information, preferably including game play with virtual money. The virtual money is acquired through game play or cash purchase. The virtual money is convertible into a non-cash good comprising advancement to another level within the game.

Abstract: An illustrative mechanical thrombectomy system may comprise an outer catheter extending from a proximal end to a distal end and defining a first lumen extending therethrough and an inner sheath extending from a proximal end to a distal end and defining a second lumen extending therethrough. The inner sheath may be slidably disposed within the first lumen of the outer catheter. An inner shaft may be slidably disposed within the second lumen of the inner sheath and an expandable anchor mechanism may be coupled to the distal end region of the inner shaft. The expandable anchor mechanism may be configured to move between a collapsed delivery configuration and an expanded configuration.

Abstract: An article includes a first microstructured layer and a second microstructured layer. The first microstructured layer includes a plurality of first microstructures forming a plurality of first grooves therebetween. The second microstructured layer includes a plurality of second microstructures disposed adjacent to the plurality of first microstructures. The plurality of second microstructures forms a plurality of second grooves therebetween. The article further includes a light absorbing material disposed in at least each of the plurality of first grooves and each of the plurality of second grooves. The light absorbing material bonds the first microstructured layer to the second microstructured layer.

Abstract: A system and method is provided for analyzing image data acquired from a patient. The method includes receiving image data associated with a patient, determining image frames with predetermined anatomical information from the cardiac image data, providing the image frames with the predetermined anatomical information to a trained model, and determining at least one of dimensional, volume, area, or physiological measurements using the trained model.

Abstract: An optical film has a major surface including a plurality of microstructures. Each microstructure includes an optical facet and a sidewall meeting the optical facet at a ridge of the microstructure. The optical facet and the sidewall define an oblique angle therebetween. For each microstructure in at least a majority of the microstructures, an optically absorptive layer is disposed on the sidewall. The optical film can include a polymeric layer having a microstructured surface at least partially coated with an inorganic optically transparent layer. The optically absorptive layer can an average thickness t where 100 nm<t<1 micrometer. A first layer can be disposed between the sidewall and the optically absorptive layer where the first layer has a lower extinction coefficient than the optically absorptive layer.

Abstract: Flexible catheters adapted to be inserted into a body to deliver high-voltage, fast (e.g., microsecond, sub-microsecond, nanosecond, picosecond, etc.) electrical energy to target tissue may include a plurality of conductive layers, that may be coaxial. These catheters and method of using them to treat tissue are configured to reduce or avoid arcing.

Abstract: A method, system and apparatus for selecting cells is disclosed. An example embodiment provides spatial information denoting the location, on a four part array of sensors, referred to as a quad array, of the center, of each particle that passes through the focused laser beam in a cell sorter. The center of a particle is commonly determined by the average fluorescence intensity within the field of view of a Side Fluorescence (SFL) collection lens. Fluorescence collected by an SFL lens from a particle having any orientation and any position in the core stream produces a spot large enough to illuminate all four segments of a quad array. By independently measuring the fluorescence intensity recorded by each of the four array segments for a particle, it is possible to calculate the x-y coordinate position across the quad array segments of the average total fluorescence emission collected from that particle.

Abstract: Described herein are systems, methods, and computer-readable medium for detecting a perfusion abnormality of a subject. In one embodiment, a method includes the following: obtaining, by dynamic radiography, imaging data for a dynamic series of a plurality of x-ray images that include areas of a subject corresponding to pulmonary vasculature; identifying, based on the imaging data, a dynamic signal corresponding to changing blood volume during the cardiac cycle of the subject; decomposing the dynamic signal into periodic components in frequency space; identifying, from the periodic components in frequency space, signals oscillating at the heart rate of the subject; generating, based on the identified signals oscillating at the heart rate of the subject, a perfusion map representation corresponding to pulmonary tissue perfusion in the subject; and detecting, based at least in part on the generated perfusion map representation, a perfusion abnormality of the subject.

Abstract: A rack has a frame and a plurality of shelves. Each shelf has an enclosing frame member that has two first sides connected by two second sides, a connecting bar that connects the first sides at about the center of the first sides, a plurality of slots provided on the inner surfaces of the second sides, and a plurality of slats, each slat having opposing ends that are fitted into opposing slots at the second sides, and with each slat being connected to the connecting bar. At least one connector is provided for removably connecting each shelf to a portion of the frame.

Abstract: Absorbent articles that include elastics in multiple layers are disclosed herein.

Abstract: Systems, methods, and apparatus for sample testing, including biochemical testing for pathogens, biomarkers, or nucleic acids, are provided. These systems, methods, and apparatus may permit asynchronous testing of two or more samples. The apparatus may include a test reaction cap configured to permit sample testing, including instances in which the test reaction cap is coupled to a sample container. The systems, methods, and apparatus may permit testing of a fluid in a sample container using a heating unit with optical detection of sample test results.

Abstract: Disclosed are compositions and methods of making a liquid fertilizer additive of biodegradable polymeric and/or oligomeric nitrification inhibitors comprised of utilizing a non-aqueous polar, aprotic organo liquid (NAPAOL) as the reaction medium for the reaction of aldehyde(s) with cyano-containing nitrification inhibitors that have one or more aldehyde reactive groups selected from the group consisting of a) primary, b) secondary amines, c) amides, d) thiols, e) hydroxyls and f) phenols.