Abstract: Certain embodiments according to the present invention provide a method for forming medical devices conformally coated with a hydrogel having a wide variety of therapeutic uses. In one aspect, certain embodiments of the invention provide a method for forming a hydrogel-coated medical device comprising immersing a medical device in a polymer solution to form an adhesive layer on an outer surface of the medical device and contacting the medical device with a hydrogel precursor solution having a pH of less than 7 to react the adhesive layer with the hydrogel precursor solution and form a conformal hydrogel coating.

Abstract: In one embodiment, a downhole drilling tool configured to engage a formation to form a wellbore includes one or more channels formed in a bit body, the channels configured to direct electromagnetic radiation. The downhole drilling tool also includes an opto-analytical device integrated with the downhole drilling tool, the opto-analytical device configured to receive electromagnetic radiation directed through the one or more channels and detect a drilling characteristic based on the received electromagnetic radiation.

Abstract: An allergy testing system comprises a skin test device having a grip portion for holding the device. One or more legs extend from the grip, and each leg is oriented to interact with a well containing a potential allergen. Each leg has a test head, and each test head has a plurality of elongated spike members. The elongated spike members have a sharp end configured to receive the potential allergen from a well and to puncture a patient's skin. In addition, each test head has at least one touch activator. The touch activator is longer than the plurality of elongated spike members, such that during an allergy test, the touch activator comes into contact with the skin prior to the elongated spike members, causing the touch activators to activate nerve tissue that blocks transmission of pain, resulting in a reduction of pain and/or discomfort during testing.

Abstract: The present invention provides compositions and methods for modulating G-alpha-q activity and methods of screening of test substances for the ability to modulate G-alpha-q activity.

Abstract: A computing device determines that a current software thread of a plurality of software threads having an issuing sequence does not have a first instruction waiting to be issued to a hardware thread during a clock cycle. The computing device identifies one or more alternative software threads in the issuing sequence having instructions waiting to be issued. The computing device selects, during the clock cycle by the computing device, a second instruction from a second software thread among the one or more alternative software threads in view of determining that the second instruction has no dependencies with any other instructions among the instructions waiting to be issued. Dependencies are identified by the computing device in view of the values of a chaining bit extracted from each of the instructions waiting to be issued. The computing device issues the second instruction to the hardware thread.

Abstract: A functionally dynamic stabilization unit and system for treatment of spinal instability are provided. Each unit, and collectively, the system, is configured to control flexion, extension and translation of the affected unstable vertebral area, thereby stabilizing the vertebral segments by restoring normal function. This is achieved by providing a unit and system that allow for lateral bending, axial compression, rotation, anterior segmental height adjustment, and posterior segmental height adjustment. The unit and system provide sufficient segmental stiffness, while also limiting, or controlling, the range of motion (i.e., sufficient stiffness in the neutral or active zone, while limiting or preventing motion outside of the active zone) to stabilize the vertebral segments. In use, the system mimics the natural movement of the normal spine. Furthermore, the system includes a rigid, fusion-promoting coupler configured for use in an adjacent level, or as a substitute for the functionally dynamic unit.

Abstract: An analyte sensor configured to be implanted in the body of the user unassisted by an introducer sharp.

Abstract: A device is provided. The device has an arcuate guide disposed about a shoe. The guide has a start point on an inner side of the shoe, an intermediate point on a heel side of the shoe, and an end point on an outer side of the shoe. The guide is angled upward across the heel side from the inner side to the outer side with the angle in a range between about 30 degrees to about 60 degrees. The start point and end point are positioned on the shoe at a point lower than the intermediate point. The device also has an indicator moveable along the guide. The indicator is an alert to the user of the device that the user has executed proper body motions during a swing or throw, when the indicator traverses from the start point through the intermediate point to the end point. Also provided is a system and method.

Abstract: An ion mobility spectrometer having an ion source for generating ions; an ion detector for recording ions, and a number of substantially flat diaphragm electrodes arranged substantially perpendicular to a straight system axis that passes through the apertures in said diaphragms, with the diaphragms being arranged in a series of cells with each cell including an entrances and an exit diaphragm and a short region in between. The exit diaphragm of one cell is identical to the entrance diaphragm of the next cell, and the cells of said ion mobility spectrometer are grouped into three parts: an ion-beam forming region, an ion analyzing region, and a decelerating ion gate.

Abstract: The present invention relates to Neisseria ORF2086 proteins, crossreactive immunogenic proteins which can be isolated from nesserial strains or prepared recombinantly, including immunogenic portions thereof, biological equivalents thereof, antibodies that immunospecifically bind to the foregoing and nucleic acid sequences encoding each of the foregoing, as well as the use of same in immunogenic compositions that are effective against infection by Neisseria meningitidis serogroup B.

Abstract: A shutter for use in a toner cartridge of an imaging device according to one example embodiment includes a toner path. The toner path includes an entrance opening positioned to receive toner and an exit opening positioned to exit toner from the toner path. An air duct through the shutter is separated from the toner path. The air duct has a first opening positioned next to the exit opening of the toner path. The air duct has a second opening.

Abstract: A power system for an electrical system with highly fluctuating loads is powered by one or more power sources that are slow to react to load changes. The power sources are connected to electrical equipment used on the drill rig which provide active load to the generators. One or more load banks may be positioned to provide passive load to the generators to maintain generally constant generator load, while allowing for instant access to power as active load increases. Generators may be run at 100% capacity, a maximum efficient capacity, or at a high enough level to allow for a sufficiently rapid increase in power output. At least one parameter of a drilling operation may be utilized to anticipate load demand changes.

Abstract: A method for writing a set of encoded data slices to memory of a dispersed storage network (DSN) begins by a processing module identifying an encoded data slice of the set of encoded data slices for a redundant write operation to produce an identified encoded data slice. The method continues with the processing module generating a set of first write requests regarding the set of encoded data slices less the identified encoded data slice and generating a set of second write requests regarding the identified encoded data slice. The method continues with the processing module sending the set of first write requests to storage units of the DSN and sending the set of second write requests to a set of storage units of the DSN, where each storage unit of the set of storage units is sent a corresponding one of the set of second write requests.

Abstract: In accordance with embodiments of the present disclosure, a method for resolving a uniform resource locator may include receiving, at a router, a uniform resource locator from a client information handling system within a local network of the router. The method may also include processing, by the router, the uniform resource locator to determine if the uniform resource locator includes a local domain name of a local information handling system within the local network. The method may further include resolving, by the router, a unique address associated with the uniform resource locator and the local information handling system responsive to determining that the uniform resource locator includes the local domain name of the local information handling system, wherein such resolving is performed without resort to a domain name service external to the local network.

Abstract: A chaining bit decoder of a computer processor receives an instruction stream. The chaining bit decoder selects a group of instructions from the instruction stream. The chaining bit decoder extracts a designated bit from each instruction of the instruction stream to produce a sequence of chaining bits. The chaining bit decoder decodes the sequence of chaining bits. The chaining bit decoder identifies zero or more instruction stream dependencies among the selected group of instructions in view of the decoded sequence of chaining bits. The chaining bit decoder outputs control signals to cause one or more pipelines stages of the processor to execute the selected group of instructions in view of the identified zero or more instruction stream dependencies among the group sequence of instructions.

Abstract: This invention describes novel adjuvant compositions and formulations with excellent stability at refrigerated and room temperatures and up to and about 37° C. that can be produced at remarkably low costs. This invention describes novel vaccine compositions and formulations to treat and prevent urinary tract infections caused by gram-negative bacteria including Escherichia coli and multi-drug resistant E. coli. This invention also describes methods of administration of said novel vaccine compositions and formulations and methods of treatment to prevent and treat urinary tract infections caused by gram-negative bacteria including E. coli and multi-drug resistant E. coli.

Abstract: A detection system and method comprising a proximal end that connects to a ventilating device, a distal end that connects to a ventilating tube, a lumen between the proximal end and the distal end, a housing surrounding the lumen that couples the proximal end and the distal end, wherein at least a portion of the housing is transparent, and at least one detection element at least partially exposed to gases in the lumen, whereby continuously monitoring the proper positioning of the ventilating tube in an airway.

Abstract: A system for biasing or encouraging a sheet of material to gather in one direction when one edge of the sheet of material is moved toward an opposite edge of the sheet of material is provided. A plurality of strips of material may extend along a face of the sheet of material and may be laminated to the face of the sheet of material. The plurality of strips of material may overlap each other and may define stiffened regions extending along the overlapped interface between the plurality of strips of material. When the covering is moved from an extended position to a retracted position, the sheet of material may gather in loops of material that may have apexes defined at or adjacent the overlapped interfaces of the plurality of strips of material.

Abstract: A new and distinct variety of peach tree. The following features of the tree and its fruit are characterized with the tree budded on ‘Nemaguard’ Rootstock (non-patented), grown on Handford sandy loam soil with Storie Index rating 95, in USDA Hardiness Zone 9, near Modesto, Calif., with standard commercial fruit growing practices, such as pruning, thinning, spraying, irrigation and fertilization. Its novelty consist of the following combination of desirable features: 1. The tree being a regular and productive bearer of medium to large size, white flesh fruit. 2. The tree with vigorous, upright growth. 3. Producing fruit with an attractive red skin color. 4. Fruit with good flavor and very good eating quality. 5. Fruit with good storage and shipping quality.

Abstract: Methods for model simulation and corresponding systems and computer-readable mediums. A method includes receiving a simulation model in the data processing system, the simulation model including at least one master joint connected to at least one slave joint by a coupling, the master joint having a rigid body master attachment and the slave joint having a rigid body slave attachment. The method includes identifying a master axis of the master attachment and a slave axis of the slave attachment. The method includes making a motor determination as to whether the master axis or the slave axis has a motor and making a cross-base determination. The method includes making a constraint determination of which bodies to constrain based on the motor determination and the cross-base determination, storing constraints according to the constraint determination, and executing the simulation model according to the constraint determination.