Abstract: This disclosure features compounds and compositions that are useful in methods of treating coronavirus infections (e.g., useful in methods of treating COVID-19) in a subject in need thereof. The methods include administering to the subject niclosamide compounds (or pharmaceutically acceptable salts and/or co-crystals thereof, e.g., niclosamide). In some embodiments, the niclosamide compounds have one or more properties that include, but are not limited to: a particular purity or a particular particle size. In an aspect, the niclosamide compounds described herein (e.g., niclosamide) can form part of compositions, dosage forms (e.g., unit dosage forms), and the like, which are suitable for respiratory administration (e.g., via inhalation and/or intranasally). In another aspect, the niclosamide compounds described herein (e.g., niclosamide) can form part of compositions, dosage forms (e.g., unit dosage forms), and the like, which are suitable for administration to the GI tract (e.g.

Abstract: A work machine including a frame, an engine, a wing and a wing lock. The wing being pivotably mounted to the frame, and the wing being actuatable between a stowed position and a deployed position. The wing lock assembly being mounted to the frame, and configured to capture a portion of the wing when the wing is in the stowed position.

Abstract: A device can pierce and hold tissue and then pass suture through tissue. The device can have a shuttle that can removably attach to a suture and jaws that can be rotatably opened and closed with respect to each other. A method for using the device to repeatedly pass the suture through the tissue without removing the suture or device from the target site is also disclosed.

Abstract: Methods, devices and system for determining fasting glucose level information and post-prandial glucose level information for diagnosing pre-diabetic and diabetic conditions based on monitored glucose measurements are provided.

Abstract: A bow may have a string latch that holds a bowstring and that can be moved into three distinct positions. One activator may be used to prevent the string latch from being moved into its second position. A second activator may be used to prevent the string latch from being moved into its third position. A third activator may be used to move the first and second activators to prevent the string latch from being moved into its second or third positions.

Abstract: Techniques are described that employ a machine learning approach for detecting data discrepancies during clinical data integration. In an embodiment, a computer implemented method comprises receiving historical clinical data messages converted from a native format to a target format via a mapping function that maps different sets of historical data elements included in the historical clinical data messages into defined data description paths, and training anomaly detection models for each of the defined data description paths to characterize normal characteristics of the different sets of historical data elements for each of the defined data description path. The method further comprises receiving new clinical data messages converted from the native format or to the target format via the mapping function, and detecting abnormal characteristics of different sets of new data elements for corresponding data description paths of the defined data description paths using the anomaly detection models.

Abstract: Approaches to selection of motion vector (“MV”) precision during video encoding are presented. These approaches can facilitate compression that is effective in terms of rate-distortion performance and/or computational efficiency. For example, a video encoder determines an MV precision for a unit of video from among multiple MV precisions, which include one or more fractional-sample MV precisions and integer-sample MV precision. The video encoder can identify a set of MV values having a fractional-sample MV precision, then select the MV precision for the unit based at least in part on prevalence of MV values (within the set) having a fractional part of zero. Or, the video encoder can perform rate-distortion analysis, where the rate-distortion analysis is biased towards the integer-sample MV precision. Or, the video encoder can collect information about the video and select the MV precision for the unit based at least in part on the collected information.

Abstract: A dividing wall column system is provided. The dividing wall column system comprises a dividing wall column, a first reboiler, a second reboiler, and a heat pump. The dividing wall column includes a dividing wall positioned in a bottom section of the dividing wall column to divide the bottom section of the dividing wall column into a first side and a second side. The first reboiler is outside of the dividing wall column and in fluid communication with the first side of the bottom section of the dividing wall column. The second reboiler is outside of the dividing wall column and in fluid communication with the second side of the bottom section of the dividing wall column. The heat pump is in fluid communication with the dividing wall column and the second reboiler and configured to compress a first portion of an overhead product from the dividing wall column.

Abstract: Disclosed are antigen binding polypeptides and antigen binding polypeptide complexes (e.g., antibodies and antigen binding fragments thereof) having certain structural features. Also disclosed are polynucleotides and vectors encoding such polypeptides and polypeptide complexes; host cells, chimeric antigen receptors (CARs), immune cells, pharmaceutical compositions and kits containing such polypeptides and polypeptide complexes; and methods of using such polypeptides and polypeptide complexes.

Abstract: Embodiments of the disclosure provide a scanner for steering optical beams. In certain configurations, the scanner may include a micro-electromechanical system (MEMS) scanning mirror independently rotatable around a first axis and a second axis orthogonal to the first axis. The scanner may further include a piezoelectric actuator coupled to the MEMS scanning mirror, where the piezoelectric actuator has a first pair of piezoelectric electrodes configured to drive the MEMS scanning mirror to rotate around the first axis, and a second pair of piezoelectric electrodes configured to drive the MEMS scanning mirror to simultaneously rotate around the second axis.

Abstract: A computer alters at least one recognizable metric or text in a digitally encoded photographic image by operating an alteration algorithm in response to user input data while preserving an overall aesthetic quality of the image and obscuring an identity of at least one individual or geographic location appearing in the image. An altered digitally-encoded photographic image prepared by the altering of the at least one recognizable metric or text in the image is stored in a computer memory. User feedback and/or automatic analysis may be performed to define parameter values of the alteration algorithm such that the alteration process achieves preservation of aesthetic qualities while obscuring an identity of interest.

Abstract: The present disclosure provides methods of synthesizing a compound of Formula (P)-I. The method proceeds through several different pathways including several novel chiral separations, a Sonogashira coupling, a zinc mediated reductive cyanation, as well as through various halide containing intermediates. Also disclosed is the multi-kilogram preparation of several novel intermediates.

Abstract: A method can include sensing condition of power cells in a configured multiple power cell pack via a pack management unit; based in part on the sensing, identifying a number of the power cells as a number of target cells via the pack management unit; disabling sensing condition of the number of target cells via the pack management unit; and reconfiguring the multiple power cell pack via the pack management unit to provide a reconfigured multiple power cell pack that provides power without the number of target cells.

Abstract: The present invention generally relates to vehicle emblems, badges, logos or design elements and in particular to a vehicle design element including a light assembly that can provide a uniform light output without the light source being viewable.

Abstract: A system for performing biological reactions is provided. The system includes a chip including a substrate and a plurality of reaction sites. The plurality of reaction sites are each configured to include a liquid sample of at most one nanoliter. Further, the system includes a control system configured to initiate biological reactions within the liquid samples. The system further includes a detection system configured to detect biological reactions on the chip. According to various embodiments, the chip includes at least 20000 reaction sites. In other embodiments, the chip includes at least 30000 reaction sites.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for processing sequences of multi-modal entity data using convolutional neural networks. One of the methods includes receiving an input sequence of multi-modal feature vectors characterizing an entity over a time window, wherein each multi-modal feature vector in the input sequence corresponds to a different time interval during the time window; processing the input sequence of multi-modal feature vectors using a convolutional neural network to generate a latent sequence that comprises a plurality of latent feature vectors; processing the latent sequence of latent feature vectors using an aggregation neural network to generate an aggregated feature vector; and processing the aggregated feature vector using an output neural network to generate a prediction that characterizes the entity after the time window.

Abstract: The invention relates to novel compounds for use as inhibitors of NLRP3 inflammasone production, wherein such compounds are as defined by compounds of formula (I) and wherein the integers R1, R2 and R3 are defined in the description, and where the compounds may be useful as medicaments, for instance for use in the treatment of a disease or disorder that is associated with NLRP3 inflammasome activity.

Abstract: An immersive display and a method of operating the immersive display to provide information relating to an object. The method includes receiving information from an input device of the immersive display or coupled to the immersive display, detecting an object based on the information received from the input device, and displaying a representation of the object on images displayed on a display of the immersive display such that attributes of the representation distinguish the representation from the images displayed on the display, wherein the representation is displayed at a location on the display that corresponds with a location of the object.

Abstract: A bone fusion device provides stability to bones during a bone fusion period. The bones include, for example, the vertebrae of a spinal column. The bone fusion device comprises one or more extendable tabs attached to the bone fusion device by associated rotating means. The bone fusion device is preferably inserted by using an arthroscopic surgical procedure. During arthroscopic insertion of the device, the tabs are pre-configured for compactness. In this compact configuration, the tabs are preferably deposed along and/or within an exterior surface of the bone fusion device. After the bone fusion device has been positioned between the bones, one or more tab(s) are extended. In the preferred embodiment, the position of each tab is related to a positioning element and extending blocks. Typically, the tabs advantageously position and brace the bone fusion device in the confined space between the bones until the bones have fused.

Abstract: An allergy testing system comprises a skin test device having a grip portion for holding the device. One or more legs extend from the grip, and each leg is oriented to interact with a well containing a potential allergen. Each leg has a test head, and each test head has a plurality of elongated spike members. The elongated spike members have a sharp end configured to receive the potential allergen from a well and to puncture a patient's skin. In addition, each test head has a touch activator. The touch activator is longer than the plurality of elongated spike members, such that during an allergy test, the touch activator comes into contact with the skin prior to the elongated spike members, causing the touch activator to activate nerve tissue that blocks transmission of pain, resulting in a reduction of pain and/or discomfort during testing.