Patents by Inventor Gary B. Gordon
Gary B. Gordon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20020093486Abstract: An optical mouse images as an array of pixels the spatial features of generally any micro textured or micro detailed work surface below the mouse. The photo detector responses are digitized and stored as a frame into memory. Motion produces successive frames of translated patterns of pixel information, which are compared by autocorrelation to ascertain the direction and amount of movement. A hold feature suspends the production of movement signals to the computer, allowing the mouse to be physically relocated on the work surface without disturbing the position on the screen ofthe pointer. This may be needed if the operator runs out of room to physically move the mouse further, but the screen pointer still needs to go further. The hold feature may be implemented with an actual button, a separate proximity detector or by detecting the presence of a characteristic condition in the digitized data, such as loss of correlation or velocity in excess of a selected limit.Type: ApplicationFiled: January 2, 2001Publication date: July 18, 2002Inventors: Gary B. Gordon, Derek L. Knee, Rajeev Badyal, Jason T. Hartlove
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Patent number: 6396479Abstract: An ergonomic mouse that alleviates mouse RSI is obtained by gripping the mouse with a pinching action between the thumb and opposing fingers while the mouse is in the U-shaped opening formed in the hand when in a neutral and unflexed condition with the little finger and the heel of the palm opposite the thumb resting upon a work surface. The mouse has two gripping surfaces; one receives the thumb and the other the opposing fingers. Indentations in the gripping surfaces help locate the finger tips. Mouse buttons are located in the indentations. The gripping surfaces are inclined toward each other, so that the pinching action to actuate the mouse buttons produces a slight downward force toward a base surface that rests upon and slides over the work surface. The little finger is allowed to drag on the work surface to assist in fine positioning. Preferably, the mouse utilizes an optical motion sensing technique instead of the conventional rubber coated steel ball.Type: GrantFiled: March 14, 2001Date of Patent: May 28, 2002Assignee: Agilent Technologies, Inc.Inventor: Gary B. Gordon
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Solid-phase chemical analysis using array hybridization facilitated by agitation during centrifuging
Publication number: 20020052042Abstract: Array hybridization can be facilitated by agitating a reaction cell subject to centrifugal force greater than 1G. A two-dimensional hybridization array is preferably oriented generally orthogonal to the centrifugal force. Agitation involves titling the array back and forth about an axis, preferably parallel to a centrifuge axis. The centrifugal force serves, in a sense, as supergravity helping to overcome non-specific binding forces (viscous forces and other forces at the liquidsolid boundary) that limit the rate of liquid flow. Thus, the agitation rate and the related replenishment rate can be increased. The agitation causes the sample liquid to wash back and forth across the array, which remains protected by a thin liquid film. The resulting “tidal” motion, results in thorough mixing of the sample liquid. In addition, since only a thin film is required over much of the array, typically costly sample volume can be reduced. Thus, faster hybridization with lower sample volumes can be achieved.Type: ApplicationFiled: December 5, 2001Publication date: May 2, 2002Inventor: Gary B. Gordon -
Patent number: 6372719Abstract: The present invention is directed to compounds of the formula and pharmaceutically acceptable salts and isomers thereof administered in combination with chemotherapeutic agents.Type: GrantFiled: March 4, 1999Date of Patent: April 16, 2002Inventors: Jay Cunningham, Gary B. Gordon, G. Allen Nickols, William F. Westlin, Thomas Edward Rogers, Peter Gerrard Ruminski
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Patent number: 6361486Abstract: A centrifuge includes a centrifuge rotor that rotates to provide supergravity conditions and tilt rotors that provide for sample agitation under the supergravity conditions. The centrifuge rotor is integral with a hollow centrifuge drive shaft. A tilt-drive shaft extends through the hollow and rotates coaxially of the centrifuge rotor. The tilt-drive shaft has a pinion that engages the tilt rotors, which thus are made to rotate about tilt axes that are spaced from and parallel to the centrifuge axis. A centrifuge motor is mechanically coupled to the centrifuge drive shaft to rotate the centrifuge rotor. A tilt motor is mechanically coupled to the tilt drive shaft for imparting a rocking motion of the tilt rotors (and thus of mounted sample reaction cells) relative to the centrifuge rotor.Type: GrantFiled: June 8, 2000Date of Patent: March 26, 2002Assignee: Agilent Technologies, Inc.Inventor: Gary B. Gordon
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Publication number: 20020001803Abstract: An improved method is provided for conducting chemical or biochemical reactions on a substrate surface in which the reactions take place in an enclosed chamber between components of a fluid and molecular moieties present on an interior surface of the chamber, wherein the improvement involves mixing the fluid during the reactions and maximizing contact between the fluid's components and the entirety of the reactive interior surface by (a) applying centrifugal force to the chamber and simultaneously (b) rotating the chamber about an axis thereof. The improved method is particularly advantageous in the context of a hybridization assay in which molecular components within a sample fluid hybridize to surface-bound molecular probes (e.g., as may be present in a spatially defined and physically addressable array) within a hybridization chamber, and wherein process and device parameters (e.g., sample volume, chamber volume, temperature, number of parts and materials, and the like) are critical.Type: ApplicationFiled: February 21, 2001Publication date: January 3, 2002Inventors: Douglas H. Smith, Gary B. Gordon
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Publication number: 20010047024Abstract: This invention relates to the use of cyclooxygenase-2 inhibitors or derivatives thereof in preventing and treating neoplasia. In particular, the invention describes the method of preventing and treating epithelial cell neoplasia in a subject, said method comprising treating the subject with a therapeutically-effective amount of a compound of Formula I.Type: ApplicationFiled: May 21, 2001Publication date: November 29, 2001Applicant: G.D. Searle & Co.Inventors: Karen Seibert, Jamie Masferrer, Gary B. Gordon
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Publication number: 20010036641Abstract: Methods and devices are disclosed for carrying out multiple chemical reactions. A plurality of electrodes supported by a semiconductor substrate is brought into proximity with a reaction medium, which comprises reagents for carrying out the chemical reactions. An item of numerical data is sent to storage means in each of a plurality of cells within the semiconductor substrate by means of a data bus. The item of numerical data is representative of an electric signal. An address is sent to address decoders in communication with the storage means. As a result, the item of numerical data is stored in the storage means. Electric signals are selectively applied to each of the electrodes by means of a plurality of digital analog converters, each electrically coupled to a respective electrode. Each of the digital analog converters is associated with a respective cell.Type: ApplicationFiled: April 25, 2001Publication date: November 1, 2001Inventors: Gary B. Gordon, Douglas J. Dellinger
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Patent number: 6309875Abstract: Array hybridization can be facilitated by agitating a reaction cell subject to centrifugal force greater than 1G. A two-dimensional hybridization array is preferably oriented generally orthogonal to the centrifugal force. Agitation involves titling the array back and forth about an axis, preferably parallel to a centrifuge axis. The centrifugal force serves, in a sense, as supergravity helping to overcome non-specific binding forces (viscous forces and other forces at the liquid-solid boundary) that limit the rate of liquid flow. Thus, the agitation rate and the related replenishment rate can be increased. The agitation causes the sample liquid to wash back and forth across the array, which remains protected by a thin liquid film. The resulting “tidal” motion, results in thorough mixing of the sample liquid. In addition, since only a thin film is required over much of the array, typically costly sample volume can be reduced. Thus, faster hybridization with lower sample volumes can be achieved.Type: GrantFiled: February 29, 2000Date of Patent: October 30, 2001Assignee: Agilent Technologies, Inc.Inventor: Gary B. Gordon
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Patent number: 6281882Abstract: An optical mouse images as an array of pixels the spatial features of generally any micro textured or micro detailed work surface below the mouse. The photo detector responses are digitized and stored as a frame into memory. Motion produces successive frames of translated patterns of pixel information, which are compared by autocorrelation to ascertain the direction and amount of movement. A hold feature suspends the production of movement signals to the computer, allowing the mouse to be physically relocated on the work surface without disturbing the position on the screen of the pointer. This may be needed if the operator runs out of room to physically move the mouse further, but the screen pointer still needs to go further. The hold feature may be implemented with an actual button, a separate proximity detector or by detecting the presence of a characteristic condition in the digitized data, such as loss of correlation or velocity in excess of a selected limit.Type: GrantFiled: March 30, 1998Date of Patent: August 28, 2001Assignee: Agilent Technologies, Inc.Inventors: Gary B. Gordon, Derek L. Knee, Rajeev Badyal, Jason T. Hartlove
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Publication number: 20010010515Abstract: An ergonomic mouse that alleviates mouse RSI is obtained by gripping the mouse with a pinching action between the thumb and opposing fingers while the mouse is in the U-shaped opening formed in the hand when in a neutral and unflexed condition with the little finger and the heel of the palm opposite the thumb resting upon a work surface. The mouse has two gripping surfaces; one receives the thumb and the other the opposing fingers. Indentations in the gripping surfaces help locate the finger tips. Mouse buttons are located in the indentations. The gripping surfaces are inclined toward each other, so that the pinching action to actuate the mouse buttons produces a slight downward force toward a base surface that rests upon and slides over the work surface. The little finger is allowed to drag on the work surface to assist in fine positioning. Preferably, the mouse utilizes an optical motion sensing technique instead of the conventional rubber coated steel ball.Type: ApplicationFiled: March 14, 2001Publication date: August 2, 2001Inventor: Gary B. Gordon
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Patent number: 6251685Abstract: A method for reading out data from microlocations of a microelectronic array involves activating multiple microlocations in parallel and simultaneously detecting the responses from the activated microlocations to determine concentrations of molecular biological material at each microlocation. In a preferred embodiment, the microelectronic array includes electronically addressable electrodes at each microlocation which can be individually activated via a control system. An electrochemiluminescent detection technique is used to detect the presence and determine the concentration of bound molecular biological material that is located at each microlocation. Electrochemiluminescent material is utilized because it gives off light when excited by an applied electrical field. With an addressable microelectronic array, electrical fields can be applied to various combinations of microlocations simultaneously to allow readout of several microlocations in parallel.Type: GrantFiled: February 18, 1999Date of Patent: June 26, 2001Assignee: Agilent Technologies, Inc.Inventors: Andreas Nikolaus Dorsel, Mel N. Kronick, Gary B. Gordon
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Patent number: 6251595Abstract: Methods and devices are disclosed for carrying out multiple chemical reactions. A plurality of electrodes supported by a semiconductor substrate is brought into proximity with a reaction medium, which comprises reagents for carrying out the chemical reactions. An item of numerical data is sent to storage means in each of a plurality of cells within the semiconductor substrate by means of a data bus. The item of numerical data is representative of an electric signal. An address is sent to address decoders in communication with the storage means. As a result, the item of numerical data is stored in the storage means. Electric signals are selectively applied to each of the electrodes by means of a plurality of digital analog converters, each electrically coupled to a respective electrode. Each of the digital analog converters is associated with a respective cell.Type: GrantFiled: June 18, 1998Date of Patent: June 26, 2001Assignee: Agilent Technologies, Inc.Inventors: Gary B. Gordon, Douglas J. Dellinger
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Patent number: 6175357Abstract: A method and system for tracking attitude of a device includes fixing a two-dimensional array of photosensors to the device and using the array to form a reference frame and a sample frame of images. The fields of view of the sample and reference frames largely overlap, so that there are common imaged features from frame to frame. Sample frames are correlated with the reference frame to detect differences in location of the common features. Based upon detection of correlations of features, an attitudinal signal indicative of pitch, yaw, and/or roll is generated. In the preferred embodiment, the attitudinal signal is used to manipulate a screen cursor of a display system, such as a remote interactive video system (RIVS). However, attitudinal tracking using the invention may be employed in other applications.Type: GrantFiled: February 11, 1998Date of Patent: January 16, 2001Assignee: Agilent Technologies Inc.Inventor: Gary B. Gordon
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Patent number: 6057540Abstract: A mouseless, optical and position translation type screen pointer control images a portion of the texture or fingerprint on one of the user's digits, which may be a thumb or a finger. Motion of the digit produces motion of the image that is detected by a movement sensor and is translated into corresponding motion of the screen pointer. The digit is placed onto an end of a rod lens that either extends upward amongst the keys: say, proximate the junction of the "H", "J", "Y" and "U" keys; or, horizontally outward from the front edge of the keyboard. As the image "moves" within the movement sensor a portion of it disappears from the field of view, and is replaced with other image patterns. A sufficiently changed image is maintained as a new current image, which then itself changes, and so on. A comparison between a reference frame (previous image) and the current frame (present image) allows detection of the amount and direction of image motion.Type: GrantFiled: April 30, 1998Date of Patent: May 2, 2000Assignee: Hewlett-Packard CoInventors: Gary B. Gordon, Donald E. Morris
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Patent number: 5972986Abstract: This invention relates to the use of cyclooxygenase-2 inhibitors or derivatives thereof in preventing and treating neoplasia. In particular, the invention describes the method of preventing and treating epithelial cell neoplasia in a subject, said method comprising treating the subject with a therapeutically-effective amount of a compound of Formula I. ##STR1## wherein A, R.sup.2 and R.sup.3 are as described in the specification.Type: GrantFiled: October 14, 1997Date of Patent: October 26, 1999Assignee: G.D. Searle & Co.Inventors: Karen Seibert, Jaime Masferrer, Gary B Gordon
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Patent number: 5954860Abstract: An injector for a gas chromatography system resistively heats an included cold trap by magnetically inducing a high-frequency current therethrough to inject absorbed analyte into a gas chromatography separation column. The injector includes a flow controller that is set initially to load analyte into the trap. A heater and a two-stage Peltier cooler are used to establish a sharp trough-shaped temperature gradient along the cold trap so that analyte loaded into the cold trap is absorbed only at a relatively cold "focussing" zone of the trap. Once the analyte is focussed, the flow controller is set to direct released analyte into the column. The magnetic-field generator includes a capacitor that is discharged to initiate cold-trap heating. An inverter converts the discharge to a 100,000 Hz waveform through a transformer primary coil. A magnetic core delivers the resulting alternating magnetic field through the cold trap.Type: GrantFiled: October 23, 1997Date of Patent: September 21, 1999Assignee: Hewlett-Packard CompanyInventor: Gary B. Gordon
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Patent number: 5786804Abstract: A method and system for tracking attitude of a device includes fixing a two-dimensional array of photosensors to the device and using the array to form a reference frame and a sample frame of images. The fields of view of the sample and reference frames largely overlap, so that there are common imaged features from frame to frame. Sample frames are correlated with the reference frame to detect differences in location of the common features. Based upon detection of correlations of features, an attitudinal signal indicative of pitch, yaw, and/or roll is generated. In the preferred embodiment, the attitudinal signal is used to manipulate a screen cursor of a display system, such as a remote interactive video system (RIVS). However, attitudinal tracking using the invention may be employed in other applications.Type: GrantFiled: October 6, 1995Date of Patent: July 28, 1998Assignee: Hewlett-Packard CompanyInventor: Gary B. Gordon
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Patent number: 5677197Abstract: An assay system for detecting the binding of a mobile reactant to an immobilized reactant on an assay plate. The assay plate includes a substrate having an assay spot deposited thereon. The assay spot includes the immobilized reactant. In the present invention, a carrier dye is included in the assay spot, the amount of the carrier dye indicating the amount of the immobilized reactant that is present in the assay spot. In the preferred embodiment of the present invention, the assay spot is generated by depositing liquid on the assay plate at a location corresponding to the assay spot. The carrier dye is dissolved in the liquid and remains after the liquid evaporates. The amount of carrier dye in each spot may be measured spectroscopically and provides a means for identifying defective assay plates.Type: GrantFiled: November 14, 1994Date of Patent: October 14, 1997Assignee: Hewlett-Packard CompanyInventors: Gary B. Gordon, Scott A. Conradson, Kay Lichtenwalter
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Patent number: 5634961Abstract: A high-performance, field-portable, thermally agile, gas chromatography (GC) system employs a low-thermal-mass oven in which intake and exhaust vent apertures are aligned with respect to the rotational axis of the stirring fan. The poppets of the vent dynamically vent to ambient the air-flow generated by the stirring fan. The geometry of the vents cooperates with the axial and radial components of the stirring fan to promote conical vortex air flow, to facilitate rapid and controllable mass-flow interchange with ambient air. The resulting cooling performance in a small GC oven promotes more rapid requilibration between runs, control at temperatures closer to ambient, and the reduction of thermal overshoot; thus enhancing the performance and productivity of a field instrument.Type: GrantFiled: November 7, 1995Date of Patent: June 3, 1997Assignee: Hewlett-Packard CompanyInventor: Gary B. Gordon