Abstract: An automated system and methods are provided for calibrating an accelerometer of a patient support apparatus using a load cell. The patient support apparatus includes a litter frame and a deck supported by the litter frame, movable between various angled positions. A patient support surface is arranged on the deck and configured to support a patient thereon. The patient support surface has at least one region configured to be disposed at an angular position. A load cell is provided, configured to generate load data including first and second load outputs detected at first and second trend angles with respect to a horizontal plane. An accelerometer is provided, configured to generate angle data including first and second angle outputs representative of the trend angles. A controller in communication with the load cell and the accelerometer determines an error in the angle data and calibrates the accelerometer.

Abstract: An automated system and methods are provided for calibrating an accelerometer of a patient support apparatus using a load cell. The patient support apparatus includes a litter frame and a deck supported by the litter frame, movable between various angled positions. A patient support surface is arranged on the deck and configured to support a patient thereon. The patient support surface has at least one region configured to be disposed at an angular position. A load cell is provided, configured to generate load data including first and second load outputs detected at first and second trend angles with respect to a horizontal plane. An accelerometer is provided, configured to generate angle data including first and second angle outputs representative of the trend angles. A controller in communication with the load cell and the accelerometer determines an error in the angle data and calibrates the accelerometer.

Abstract: The present disclosure provides novel hemi- and mono-salts of 7-[(3R,4R)-3-Hydroxy-4-hydroxymethyl-pyrrolidin-1-ylmethyl]-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one (Compound 1) with various organic and inorganic acids. In one embodiment, the organic acid is a C4 organic diacids. The present disclosure further provides novel methods for preparing these salts. The novel monohydrates hemisalts of the C4 organic diacids are isostructural and can be prepared with different properties. Multiple acids can be used simultaneously and the proportion of acids can be varied offering the opportunity to select hemi-salts of compound 1 with desired properties.

Abstract: The present disclosure provides novel hemi- and mono-salts of 7-[(3R,4R)-3-Hydroxy-4-hydroxymethyl-pyrrolidin-1-ylmethyl]-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one (Compound 1) with various organic and inorganic acids. In one embodiment, the organic acid is a C4 organic diacids. The present disclosure further provides novel methods for preparing these salts. The novel monohydrates hemisalts of the C4 organic diacids are isostructural and can be prepared with different properties. Multiple acids can be used simultaneously and the proportion of acids can be varied offering the opportunity to select hemi-salts of compound 1 with desired properties.

Abstract: A roller thrust bearing assembly is effective to transmit force along a path extending between two members. The roller thrust bearing assembly includes a circular disc with an annular array of spaced apart slots. Each of the slots has a longitudinal central axis which is skewed at the same angle relative to disc radii. A plurality of roller bearings are disposed in each of the slots.

Abstract: Taxane prodrugs comprise a taxane joined by a hydrolyzable bond to one or more oligomers that comprise a polyethylene glycol moiety. The oligomer preferably further comprises a salt-forming moiety.