Patents by Inventor Gary Bowlin
Gary Bowlin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12171888Abstract: The invention generally relates to dextran fibers which are preferably electrospun and devices formed from such fibers. In particular, such devices may include substances of interest (such as therapeutic substances) associated with the electrospun fibers. Upon exposure to a liquid the electrospun fibers dissolve immediately and the substances of interest are released into the liquid. Exemplary devices include bandages formed from electrospun dextran fibers and associated agents that promote hemostasis, such as thrombin and fibrinogen.Type: GrantFiled: December 1, 2021Date of Patent: December 24, 2024Assignees: Virginia Commonwealth University, The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.Inventors: Gary Bowlin, David Simpson, James Bowman, Stephen Rothwell
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Publication number: 20220249732Abstract: The invention generally relates to dextran fibers which are preferably electrospun and devices formed from such fibers. In particular, such devices may include substances of interest (such as therapeutic substances) associated with the electrospun fibers. Upon exposure to a liquid the electrospun fibers dissolve immediately and the substances of interest are released into the liquid. Exemplary devices include bandages formed from electrospun dextran fibers and associated agents that promote hemostasis, such as thrombin and fibrinogen.Type: ApplicationFiled: December 1, 2021Publication date: August 11, 2022Inventors: Gary Bowlin, David Simpson, James Bowman, Stephen Rothwell
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Publication number: 20180344891Abstract: The invention generally relates to dextran fibers which are preferably electrospun and devices formed from such fibers. In particular, such devices may include substances of interest (such as therapeutic substances) associated with the electrospun fibers. Upon exposure to a liquid the electrospun fibers dissolve immediately and the substances of interest are released into the liquid. Exemplary devices include bandages formed from electrospun dextran fibers and associated agents that promote hemostasis, such as thrombin and fibrinogen.Type: ApplicationFiled: August 13, 2018Publication date: December 6, 2018Inventors: Gary Bowlin, David Simpson, James Bowman, Stephen Rothwell
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Patent number: 10046081Abstract: The invention generally relates to dextran fibers which are preferably electrospun and devices formed from such fibers. In particular, such devices may include substances of interest (such as therapeutic substances) associated with the electrospun fibers. Upon exposure to a liquid the electrospun fibers dissolve immediately and the substances of interest are released into the liquid. Exemplary devices include bandages formed from electrospun dextran fibers and associated agents that promote hemostasis, such as thrombin and fibrinogen.Type: GrantFiled: July 29, 2014Date of Patent: August 14, 2018Assignees: The Henry M Jackson Foundation for the Advancement of Military Medicine, Inc., Virginia Commonwealth UniversityInventors: Gary Bowlin, David Simpson, James Bowman, Stephen Rothwell
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Patent number: 9572909Abstract: Nerve guides which are formed from three dimensional (3D) arrays of highly aligned electrospun fibers are provided. The electrospun fibers are oriented parallel to the long axis of the guide, and gaps and elongated spaces between the stacked fiber arrays provide channels for directed axonal growth. In some embodiments, the nerve guides also comprise high precision gradients of beneficial substances such as growth factors, which aid in nerve regeneration and growth along the guide.Type: GrantFiled: September 14, 2010Date of Patent: February 21, 2017Assignee: Virginia Commonwealth UniversityInventors: David Simpson, Gary Bowlin, Raymond Colello, Woon Chow, Balendu Shekhar Jha
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Publication number: 20160175477Abstract: The invention generally relates to dextran fibers which are preferably electrospun and devices formed from such fibers. In particular, such devices may include substances of interest (such as therapeutic substances) associated with the electrospun fibers. Upon exposure to a liquid the electrospun fibers dissolve immediately and the substances of interest are released into the liquid. Exemplary devices include bandages formed from electrospun dextran fibers and associated agents that promote hemostasis, such as thrombin and fibrinogen.Type: ApplicationFiled: July 29, 2014Publication date: June 23, 2016Inventors: Gary Bowlin, David Simpson, James Bowman, Stephen Rothwell
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Publication number: 20150112287Abstract: The invention generally relates to dextran fibers which are preferably electrospun and devices formed from such fibers. In particular, such devices may include substances of interest (such as therapeutic substances) associated with the electrospun fibers. Upon exposure to a liquid the electrospun fibers dissolve immediately and the substances of interest are released into the liquid. Exemplary devices include bandages formed from electrospun dextran fibers and associated agents that promote hemostasis, such as thrombin and fibrinogen.Type: ApplicationFiled: July 29, 2014Publication date: April 23, 2015Inventors: Gary Bowlin, David Simpson, James Bowman, Stephen Rothwell
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Publication number: 20130310779Abstract: High-pressure bleeding wounds (and other bleeding wounds) may be treated by applying direct pressure directly in the bleeding wound, such as by applying a back pressure in a confined space around and in the wound. Certain substances and articles may be inserted into the wound, and the wound may be enclosed with that substance or article (such as a hemostatic substance, which may be polymeric), by swelling on contact with molecules (such as water molecules in the blood) encountered in the wound, generates the desired pressure to stop or at least reduce the bleeding without the detrimental effects of a tourniquet. Clot-inducing substances may be introduced into the wound contemporaneously with direct pressure application directly in the wound. Compressible and non-compressible wounds are treated. Treatment stops bleeding without producing pressure injury or ischemic damage. Medical devices using this technology are provided, including removable, biodegradable, medic-administrable devices.Type: ApplicationFiled: July 26, 2013Publication date: November 21, 2013Applicant: Virginia Commonwealth UniversityInventors: Gary Wnek, Marcus E. Carr, JR., Gary Bowlin, Kelman I. Cohen, Kevin R. Ward, Wayne Barbee, Rao Ivatury
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Publication number: 20130289471Abstract: This invention provides articles of manufacture and bandages comprising compartments and layers comprising oxygen and other therapeutic gas storage forms and perfluorocarbons. This invention also provides for methods of delivering oxygen and other therapeutic gases to a tissue in a subject comprising a administering to the tissue a composition comprising a perfluorocarbon and a oxygen or therapeutic gas storage form, so as to thereby deliver oxygen or the therapeutic gas to the tissue.Type: ApplicationFiled: May 3, 2013Publication date: October 31, 2013Applicants: Virginia Commonwealth University, Oxygen Biotherapeutics, Inc.Inventors: Kevin R. Ward, Robert Diegelmann, Bruce Spiess, Gary S Huvard, Gurbhagat S Sandhu, Gary Bowlin, Chris Stern
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Patent number: 8497408Abstract: High-pressure bleeding wounds (and other bleeding wounds) may be treated by applying direct pressure directly in the bleeding wound, such as by applying a back pressure in a confined space around and in the wound. Certain substances and articles may be inserted into the wound, and the wound may be enclosed with that substance or article (such as a hemostatic substance, which may be polymeric), by swelling on contact with molecules (such as water molecules in the blood) encountered in the wound, generates the desired pressure to stop or at least reduce the bleeding without the detrimental effects of a tourniquet. Clot-inducing substances may be introduced into the wound contemporaneously with direct pressure application directly in the wound. Compressible and non-compressible wounds are treated. Treatment stops bleeding without producing pressure injury or ischemic damage. Medical devices using this technology are provided, including removable, biodegradable, medic-administrable devices.Type: GrantFiled: September 14, 2007Date of Patent: July 30, 2013Assignee: Virginia Commonwealth UniversityInventors: Gary Wnek, Marcus E. Carr, Jr., Gary Bowlin, Kelman I. Cohen, Kevin R. Ward, Wayne Barbee, Rao Ivatury
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Publication number: 20120221025Abstract: Nerve guides which are formed from three dimensional (3D) arrays of highly aligned electrospun fibers are provided. The electrospun fibers are oriented parallel to the long axis of the guide, and gaps and elongated spaces between the stacked fiber arrays provide channels for directed axonal growth. In some embodiments, the nerve guides also comprise high precision gradients of beneficial substances such as growth factors, which aid in nerve regeneration and growth along the guide.Type: ApplicationFiled: September 14, 2010Publication date: August 30, 2012Inventors: David Simpson, Gary Bowlin, Raymond Colello, Woon Chow, Balendu Shekhar Jha
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Publication number: 20120184898Abstract: This invention provides articles of manufacture and bandages comprising compartments and layers comprising oxygen and other therapeutic gas storage forms and perfluorocarbons. This invention also provides for methods of delivering oxygen and other therapeutic gases to a tissue in a subject comprising a administering to the tissue a composition comprising a perfluorocarbon and a oxygen or therapeutic gas storage form, so as to thereby deliver oxygen or the therapeutic gas to the tissue.Type: ApplicationFiled: March 28, 2012Publication date: July 19, 2012Inventors: Kevin R. Ward, Robert Diegelmann, Bruce Spiess, Gary S. Huvard, Gurbhagat S. Sandhu, Gary Bowlin, Chris Stern
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Publication number: 20090202617Abstract: This invention provides articles of manufacture and bandages comprising compartments and layers comprising oxygen and other therapeutic gas storage forms and perfluorocarbons. This invention also provides for methods of delivering oxygen and other therapeutic gases to a tissue in a subject comprising a administering to the tissue a composition comprising a perfluorocarbon and a oxygen or therapeutic gas storage form, so as to thereby deliver oxygen or the therapeutic gas to the tissue.Type: ApplicationFiled: February 13, 2009Publication date: August 13, 2009Inventors: Kevin R. Ward, Robert Diegelmann, Bruce Spiess, Gary S. Huvard, Gurbhagat S. Sandhu, Gary Bowlin, Chris Stern
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Publication number: 20080038352Abstract: The invention is directed to formation and use of electroprocessed collagen, including use as an extracellular matrix and, together with cells, its use in forming engineered tissue. The engineered tissue can include the synthetic manufacture of specific organs or tissues which may be implanted into a recipient. The electroprocessed collagen may also be combined with other molecules in order to deliver substances to the site of application or implantation of the electroprocessed collagen. The collagen or collagen/cell suspension is electrodeposited onto a substrate to form tissues and organs.Type: ApplicationFiled: August 21, 2007Publication date: February 14, 2008Applicants: Virginia Commonwealth University Intellectual Property Foundation, Nanomatrix, Inc.Inventors: David Simpson, Gary Bowlin, Gary Wnek, Peter Stevens, Marcus Carr, Jamil Matthews, Saravanamoorthy Rajendran
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Publication number: 20080009898Abstract: High-pressure bleeding wounds (and other bleeding wounds) may be treated by applying direct pressure directly in the bleeding wound, such as by applying a back pressure in a confined space around and in the wound. Certain substances and articles may be inserted into the wound, and the wound may be enclosed with that substance or article (such as a hemostatic substance, which may be polymeric), by swelling on contact with molecules (such as water molecules in the blood) encountered in the wound, generates the desired pressure to stop or at least reduce the bleeding without the detrimental effects of a tourniquet. Clot-inducing substances may be introduced into the wound contemporaneously with direct pressure application directly in the wound. Compressible and non-compressible wounds are treated. Treatment stops bleeding without producing pressure injury or ischemic damage. Medical devices using this technology are provided, including removable, biodegradable, medic-administrable devices.Type: ApplicationFiled: September 14, 2007Publication date: January 10, 2008Inventors: Gary WNEK, Marcus Carr, Gary Bowlin, Kelman Cohen, Kevin Ward, Wayne Barbee, Rao Ivatury
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Publication number: 20070225631Abstract: The present invention relates to sealants for skin and other tissues. The sealants include an electroprocessed material. The sealants may contain more than one electroprocessed materials and may contain additional substances. The invention further relates to methods of making and using such sealants.Type: ApplicationFiled: October 6, 2003Publication date: September 27, 2007Inventors: Gary Bowlin, David Simpson, Gary Wnek, Marcus Carr, Peter Stevens, Gary Cadd, I. Cohen
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Publication number: 20050192622Abstract: An electroprocessed matrix of polymer, and specifically an electrospun matrix of fibers is attached to a substrate be using electroprocessing technique variations. First the electroprocessing equipment is configured to coat a substrate with a layer of electrosprayed droplets or wet, electrospun fibers, or a mixture thereof. The equipment is then modified to form an electrospun matrix of fibers onto the coated substrate.Type: ApplicationFiled: April 1, 2005Publication date: September 1, 2005Inventor: Gary Bowlin
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Publication number: 20040013715Abstract: High-pressure bleeding wounds (and other bleeding wounds) may be treated by applying direct pressure directly in the bleeding wound, such as by applying a back pressure in a confined space around and in the wound. Certain substances and articles may be inserted into the wound, and the wound may be enclosed with that substance or article (such as a hemostatic substance, which may be polymeric), by swelling on contact with molecules (such as water molecules in the blood) encountered in the wound, generates the desired pressure to stop or at least reduce the bleeding without the detrimental effects of a tourniquet Clot-inducing substances may be introduced into the wound contemporaneously with direct pressure application directly in the wound. Compressible and non-compressible wounds are treated. Treatment stops bleeding without producing pressure injury or ischemic damage. Medical devices using this technology are provided, including removable, biodegradable, medic-administrable devices.Type: ApplicationFiled: August 13, 2003Publication date: January 22, 2004Inventors: Gary Wnek, Marcus E Carr, Gary Bowlin, Kelman I Cohen, Kevin R Ward, Wayne Barbee, Rao Ivatury