Abstract: Provided herein are trispecific and/or trivalent binding proteins comprising four polypeptide chains that form three antigen binding sites that specifically bind one or more target proteins, wherein a first pair of polypeptides forming the binding protein possess dual variable domains having a cross-over orientation, and wherein and a second pair of polypeptides possess a single variable domain forming a single antigen binding site. In some embodiments, the binding proteins comprise a binding site that binds a CD28 polypeptide, a binding site that binds a CD3 polypeptide, and a binding site that binds a third polypeptide, such as a tumor target protein. In some embodiments, the binding proteins comprise four polypeptide chains that form three antigen binding sites that specifically bind one or more HIV target proteins. The disclosure also relates to methods for making trispecific and/or trivalent binding proteins and uses of such binding proteins.

Abstract: An improved motor vehicle electrical system includes a flexible topology DC-to-DC converter for coupling an engine-driven alternator to vehicle electrical loads at a mode-dependent transfer ratio. The output voltage of the alternator is regulated based the load voltage, and the converter is operable in one of a number of different modes based on engine speed, including a forward boost mode, a forward unity mode, and a forward buck mode. In the forward boost mode, the converter output voltage is boosted above that of the alternator to enable battery charging at low engine speeds; in the forward unity mode, the alternator output voltage is transferred to the battery and electrical loads at a unity transfer ratio; and in the forward buck mode, the converter output voltage is reduced below that of the alternator to enhance the alternator power output at medium-to-high engine speeds.

Abstract: A mop assembly is described, which includes a triangularly-shaped support bar having straight terminal end portions attached to a mop handle by two or more transverse bolts. A central bar portion of the triangularly shaped support bar cooperates with an elongated rail to form a clamped connection between the support bar and an essentially conventional flexible dirt pick-up means. The triangular support bar is preferably formed out of aluminum bar stock having a rectangular cross-section.