Abstract: Disclosed are methods of inhibiting, regulating, and/or modulating the formation of soluble, globular, non-fibrillar, neurotoxic amyloid ?1-42 oligomers from amyloid ?1-42 monomers using acylhydrazide compounds. Also disclosed are methods of treating a patient suffering from diseases associated with the formation of soluble, globular, non-fibrillar, neurotoxic amyloid ?1-42 oligomers using acylhydrazide compounds.

Abstract: Correspondence is determined among i) groups in a first version of one or more groups of related tables and ii) groups in a second version of one or more groups of related tables. The tables have schema and table names and determining the correspondence includes matching groups that have matching tables, wherein the matching tables have matching schema and table names. A user interface is displayed, including first and second portions. A group name list is displayed for the one or more groups of the first version in the first user interface portion and of the second version in the second portion. A list of one or more tables within each respectively displayed group is displayed. Within each group of the first version the one or more table names are in visual alignment with respective corresponding one or more table names of the respective corresponding group of the second version.

Abstract: An insulation system includes at least one turbine insulation compartment configured to enclose at least a portion of a turbine; an insulation storage compartment configured to store a supply of insulation; a plurality of first pipes that connect to the turbine insulation compartment and the insulation storage compartment; and a blower configured to generate a flow of air in at least one first pipe to pneumatically convey insulation between the insulation storage compartment and the at least one turbine insulation compartment. A method of insulating at least a portion of a turbine includes enclosing at least a portion of the turbine in a compartment; and conveying insulation into the compartment.

Abstract: This invention describes compounds useful as ubiquitin ligase inhibitors. The compounds of the invention are useful as inhibitors of the biochemical pathways of organisms in which ubiquitination is involved. The invention also provides for pharmaceutical compositions comprising the compounds described in the invention for the treatment of conditions that require inhibition of ubiquitin ligases. Furthermore, the invention provides for methods of inhibiting ubiquitination in a cell comprising contacting a cell in which inhibition of ubiquitination is desired with a compound according to the invention.

Abstract: An electrode for an electrochemical machining process is provided. The electrode comprises a curved, electrically conductive member, and an insulating coating covering at least a portion of a side surface of the curved, electrically conductive member. An electrochemical machining assembly is also provided for machining curved holes in a workpiece. The assembly includes at least one curved electrode and a power supply operatively connected to provide a pulsed voltage to the at least one curved electrode and to the workpiece. The assembly further includes a rotational driver operatively connected to move the at least one curved electrode along a curved path within the workpiece. The assembly is configured to remove material from the workpiece upon application of the pulsed voltage to the at least one curved electrode and to the workpiece. An electrochemical machining method is also provided for forming one or more curved holes in an electrically conductive workpiece.

Abstract: Embodiments of the invention can provide systems, methods, and an apparatus for providing a magnetic seal. According to one embodiment, a system having a magnetic seal can be provided. The system can include a rotary machine having a first component and a second component. A magnetic seal can be mounted to the first component and positioned relative to the second component to provide a gap between the magnetic seal and the second component. The magnetic seal can include a first magnetic element and a compliant material adapted to adjust in response to a force exerted on the magnetic seal by a second magnetic element. The second magnetic element can be mounted to the second component so that the gap between the magnetic seal and the second component can be modified in response to the force exerted by second magnetic element on the magnetic seal.

Abstract: The present invention provides a method for storing holographic data comprising providing a holographic storage medium comprising an optically transparent substrate including a photochemically active dye having at least two nitrone groups; and irradiating the optically transparent substrate with a holographic interference pattern, wherein the pattern has a first wavelength and an intensity both sufficient to convert, within a volume element of the substrate, at least some of the photochemically active dye into a photo-product, and producing within the irradiated volume element concentration variations of the photo-product corresponding to the holographic interference pattern, thereby producing a first optically readable datum corresponding to the volume element.

Abstract: The virtual supercomputer is an apparatus, system and method for generating information processing solutions to complex and/or high-demand/high-performance computing problems, without the need for costly, dedicated hardware supercomputers, and in a manner far more efficient than simple grid or multiprocessor network approaches. The virtual supercomputer consists of a reconfigurable virtual hardware processor, an associated operating system, and a set of operations and procedures that allow the architecture of the system to be easily tailored and adapted to specific problems or classes of problems in a way that such tailored solutions will perform on a variety of hardware architectures, while retaining the benefits of a tailored solution that is designed to exploit the specific and often changing information processing features and demands of the problem at hand.

Abstract: A repair method of propagating epitaxial crystalline structures is provided. The repair method broadly comprises the steps of providing a substrate to be repaired, placing an additive material as a preformed shape onto an area of the substrate to be repaired, utilizing a heat source to heat an entire volume of the additive material and an area adjacent to the additive material to within 0-100° F. of their solidus temperatures, holding at the fusion temperature for a time sufficient to allow grain growth and orientation to occur, and ramping down the heat source at a predetermined controlled rate until solidification is complete.

Abstract: The virtual supercomputer is an apparatus, system and method for generating information processing solutions to complex and/or high-demand/high-performance computing problems, without the need for costly, dedicated hardware supercomputers, and in a manner far more efficient than simple grid or multiprocessor network approaches. The virtual supercomputer consists of a reconfigurable virtual hardware processor, an associated operating system, and a set of operations and procedures that allow the architecture of the system to be easily tailored and adapted to specific problems or classes of problems in a way that such tailored solutions will perform on a variety of hardware architectures, while retaining the benefits of a tailored solution that is designed to exploit the specific and often changing information processing features and demands of the problem at hand.

Abstract: In one embodiment, a coverplate may be configured to axially overlay a plurality of blade retaining slots within a wheel post of a rotor wheel. The coverplate may include a tab for radially securing the coverplate within a complementary groove of the rotor wheel and an aperture configured to align with a corresponding aperture of the turbine wheel to receive a fastener for axially securing the coverplate to the rotor wheel.

Abstract: The present invention, termed the Interactive Organic Agent (IOA), augments electronic procurement shopping software with functionality that enables the purchasing organization to capture, in real-time, any changes in supplier item price and availability, as the buyer (user) is shopping or browsing the buyer-side remote catalog index. In particular, as the buyer is viewing remote-catalog pages of items that have been selected as the result of a search, or simply via browsing, the IOA automatically, without any required user action, makes a direct connection to the live supplier online site(s) that correspond to the items being viewed, and then retrieves the latest price & availability data.

Abstract: A device for reducing secondary airflow in a gas turbine is disclosed. The device includes an inter-stage sealing member located between a plurality of first turbine buckets attached to a first rotor disk, and a plurality of second turbine buckets attached to a second rotor disk. The first rotor disk and the second rotor disk are rotatable about a central axis. The inter-stage sealing member is configured to be attached in a fixed position relative to the first rotor disk and the second rotor disk, and to contact the plurality of first buckets and the plurality of second buckets in a sealing engagement.

Abstract: An apparatus and method suitable for supporting a cylindrical component. The apparatus includes a pedestal having an upper surface with a semispherical concave shape, and a carriage supported on the upper surface of the pedestal. The carriage has a lower surface and an oppositely-disposed upper surface with elements for contacting and rotatably supporting the cylindrical component. The lower surface of the carriage engages the upper surface of the pedestal and has a semispherical convex shape complementary to the semispherical concave shape of the upper surface of the pedestal. The apparatus further includes a reservoir at and recessed in the upper surface of the pedestal, and a feature for delivering a lubricant to the lubricant reservoir. The lower surface of the carriage and the upper surface of the pedestal define an enclosure around the reservoir.

Abstract: A damping system for a turbine bucket. The damping system includes a damper pocket with a variable tangential depth and a damper pin positional within the damper pocket.

Abstract: Methods and apparatus, including computer program products, implementing and using techniques for managing database table schema evolution. It is detected whether any columns in a source table have been renamed since a previous archiving process. A set of table changes is generated for the renamed columns. It is detected whether any possible naming collisions exist in the set of table changes. If a possible naming collision is detected, a temporary rename is created for the renamed column. The set of table changes, including any created temporary renames, is sorted.

Abstract: A seal ring includes a weld and a thermoplastic material. The thermoplastic material has a weld elongation-at-break of at least 3%. The thermoplastic material can have a glass transition temperature of at least 100° C. The thermoplastic material with the weld can have a weld elongation-at-break of at least 3%. The seal ring can have a circumference of at least 0.62 meters. The seal ring can have a coefficient of friction of not greater than 0.45.

Abstract: A method of forming a seal ring includes heating an extruded rod to a temperature above a glass transition temperature. The extruded rod has first and second ends. The method further includes bending the extruded rod into a circular structure while the temperature is above the glass transition temperature, joining the first and second ends of the extruded rod to form a semi-finished ring, and annealing the semi-finished ring.

Abstract: A method for preparing an aliphatic chloroformate comprising, introducing a mixture of at least one aliphatic hydroxyl compound, phosgene, at least one solvent, and optionally at least one organic base into a flow reactor to obtain a unidirectional flowing reaction mixture. The at least one aliphatic hydroxyl compound comprises at least one aliphatic hydroxyl group. The unidirectional flowing reaction mixture is maintained at a temperature between about 0° C. and about 60° C. to produce a single product stream comprising an aliphatic chloroformate.

Abstract: An article includes a porous membrane having pores, a first selectively permeable coating supported by the membrane and a component protective against delamination of the selectively permeable coating from the porous membrane and/or any other coatings applied thereto. The first selectively permeable coating includes an antichemical, antibiological, antiradiological and/or antimicrobial agent. The protective component may be provided alone, or as an element of the first selectively permeable coating, or, a second selectively permeable coating. A laminate and methods of providing these are also provided.