Abstract: A doped substrate having a substrate comprising at least one of a glass material, a single crystal material, a poly-crystalline material, a ceramic material, or a semiconductor material. The doped substrate includes a dopant comprising one or more transition metals, one or more rare earth elements, or a combination of both, the doped substrate characterized in that a spectral laser output of the doped substrate exhibits a nominally single frequency having a linewidth less than about 5 nm.

Abstract: A method of forming a doped substrate comprises heating a substrate comprising a layer of a dopant on at least one surface to a predetermined temperature; applying a predetermined degree of isostatic external pressure on the surface of said substrate at said predetermined temperature for a time sufficient to induce thermal migration of the dopant into the substrate to provide a doped substrate; and removing the isostatic pressure and cooling the doped substrate to about room temperature. The substrate is a glass material, a single crystal material, a poly-crystalline material, a ceramic material, or a semiconductor material, and the substrate may be optically transparent. The dopant comprises one or more transition metals, one or more rare earth elements, or a combination of both. The layer of a dopant comprises one or more segregated layers of distinct chemical species. The isostatic pressure and elevated temperature may be applied simultaneously or sequentially.

Abstract: A gas monitoring system and method(s) of use is described. Embodiments of the gas monitoring system can include a gas detection system and one or more tubing assemblies. The gas detection system can be configured to determine if sampled air contains a particular gas or gases. The one or more tubing assemblies can be fluidly connected to the gas detection system to provide air from an area to be monitored. The one or more tubing assemblies may include a dynamic tubing assembly configured as a vane.

Abstract: Apparatus and methods for opening bags, wherein the method comprises: positioning the bag upon two or more gripping members; gripping a first section and a second section of the bag with the gripping members, wherein a third section of the bag is between the first section and the second section of the bag; heating the bag along the third section of the bag to form a heated section within the third section of the bag; inserting one or more ripping members into the third section of the bag; moving at least one of the ripping members inserted into the third section of the bag along the third section of the bag to form a tear in the bag within the heated section of the bag; and moving at least one of the gripping members apart from at least one other of the gripping members to move the first section of the bag apart from the second section of the bag, thereby enlarging the tear in the bag.

Abstract: Embodiments of the modular fracking ball assembly can include, but are not limited to, a measurement assembly, a shock absorbing layer, and an outer shell. The shock absorbing layer can encase the measurement assembly and the outer shell can encase the shock absorbing layer and the measurement assembly. The outer shell of the modular fracking ball assembly can be replaced with another outer shell when a change in parameters of the modular fracking ball assembly is needed. For instance, an overall diameter or a specific gravity of the modular fracking ball assembly can be changed by swapping outer shells.

Abstract: A method of treating a substrate comprises applying an electric field to a substrate comprising a layer of a dopant on at least one surface; applying a predetermined temperature to the substrate in the electric field; applying the electric field and the predetermined temperature for a time sufficient to induce migration of the dopant into the substrate to provide a doped substrate; and removing the electric field and returning the doped substrate to about room temperature, wherein the doped substrate is characterized in that a spectral laser output of the doped substrate exhibits a nominally single frequency having a linewidth less than about 5 nm. The substrate may be a glass material, a single crystal material, a poly-crystalline material, a ceramic material, or a semiconductor material, which may be optically transparent. Before treatment, the substrate may be an undoped substrate or a doped substrate.

Abstract: A method of treating a substrate comprises applying an electric field to a substrate comprising a layer of a dopant on at least one surface; applying a predetermined temperature to the substrate in the electric field; applying the electric field and the predetermined temperature for a time sufficient to induce migration of the dopant into the substrate to provide a doped substrate; and removing the electric field and returning the doped substrate to about room temperature, wherein the doped substrate is characterized in that a spectral laser output of the doped substrate exhibits a nominally single frequency having a linewidth less than about 5 nm. The substrate may be a glass material, a single crystal material, a poly-crystalline material, a ceramic material, or a semiconductor material, which may be optically transparent. Before treatment, the substrate may be an undoped substrate or a doped substrate.

Abstract: A modular fracking ball assembly and method(s) of use thereof is described. Embodiments of the modular fracking ball assembly can include, but are not limited to, a measurement assembly, a shock absorbing layer, and an outer shell. The shock absorbing layer can encase the measurement assembly and the outer shell can encase the shock absorbing layer and the measurement assembly. The outer shell of the modular fracking ball assembly can be replaced with another outer shell when a change in parameters of the modular fracking ball assembly is needed. For instance, an overall diameter or a specific gravity of the modular fracking ball assembly can be changed by swapping outer shells.

Abstract: A method of forming a doped substrate comprises heating a substrate comprising a layer of a dopant on at least one surface to a predetermined temperature; applying a predetermined degree of isostatic external pressure on the surface of said substrate at said predetermined temperature for a time sufficient to induce thermal migration of the dopant into the substrate to provide a doped substrate; and removing the isostatic pressure and cooling the doped substrate to about room temperature. The substrate is a glass material, a single crystal material, a poly-crystalline material, a ceramic material, or a semiconductor material, and the substrate may be optically transparent. The dopant comprises one or more transition metals, one or more rare earth elements, or a combination of both. The layer of a dopant comprises one or more segregated layers of distinct chemical species. The isostatic pressure and elevated temperature may be applied simultaneously or sequentially.

Abstract: A method of treating a substrate comprises applying an electric field to a substrate comprising a layer of a dopant on at least one surface; applying a predetermined temperature to the substrate in the electric field; applying the electric field and the predetermined temperature for a time sufficient to induce migration of the dopant into the substrate to provide a doped substrate; and removing the electric field and returning the doped substrate to about room temperature, wherein the doped substrate is characterized in that a spectral laser output of the doped substrate exhibits a nominally single frequency having a linewidth less than about 5 nm. The substrate may be a glass material, a single crystal material, a poly-crystalline material, a ceramic material, or a semiconductor material, which may be optically transparent. Before treatment, the substrate may be an undoped substrate or a doped substrate.

Abstract: Systems and methods for employing an electro-optic and photoconductive optical element operating in combination with a polarizer and 100% reflective mirrors to passively control dumping of power from a resonator. The optical element may be constructed of electro-optic material (e.g., Bismuth Silicon Oxide (BSO), Bismuth Germanium Oxide (BGO)), the refractive index of which may be altered by the application of an externally applied electric field. The presence of incident light changes the photoconductivity of the optical element and, therefore, also changes the polarization state of the light passing through the optical element. When combined with a conventional polarizer, the device acts as a self-triggering optical valve to suddenly divert the path of light within a laser to outside of the normal resonator path. Optical power that has been stored inside the laser resonator is then dumped out of the laser in a single, very-high power pulse.

Abstract: The invention relates to aqueous solution pharmaceutical compositions comprising at least one non-ionic tonicity agent, at least one buffer and an active ingredient, wherein said active ingredient is a compound of formula I, wherein R1-R9 are defined herein; processes for preparing these compositions and their use in medicine, especially their use in the treatment of ocular diseases.

Abstract: The present invention is directed to methods and apparatus for tempering the temperature of a liquid in a fluid conducting system. More particularly, some embodiments of the invention relates to tempering the temperature of water supplied to a fixture from a water heater in a fluid conducting system. The system can include a heater for heating the fluid and a diffuser for slowing the rate at which water provided to a decontamination fixture is heated.

Abstract: Disclosed herein are formulations of dexamethasone or a prodrug thereof suitable for delivery by ocular iontophoresis and methods of use thereof.

Abstract: Solid state lasers emitting at first and a second wavelengths include an additional a conversion amplifier for converting photons having the first wavelength into photons having the second wavelength, thereby improving output efficiency of a preferred wavelength. Erbium lasing materials such as erbium doped garnets and fluorides, are employed, along with the conversion amplifier formed of a transition metal doped II-VI semiconductor, e.g., Cr:ZnSe.

Abstract: The present disclosure is directed to compositions, formulations and methods of use thereof in the treatment and prevention of ocular conditions including cataract and presbyopia.

Abstract: A universal polarization converter is provided including a polarizer configured to receive unpolarized light. The polarizer is further configured to split the received unpolarized light into a first and second polarized state. At least two quarter wave phase retarders are configured to convert each of the first and second polarized states to opposite handed polarized beams. A cholesteric mirror is configured to combine the opposite handed polarized beams. In other embodiments, the cholesteric mirror may be replaced by a second polarizer and optional quarter wave retardation plate. Further embodiments may include a single polarization converter and multiple quarter wave retardation plates.

Abstract: Disclosed herein are formulations of dexamethasone or a prodrug thereof suitable for delivery by ocular iontophoresis and methods of use thereof.

Abstract: A universal polarization converter is provided including a polarizer configured to receive unpolarized light. The polarizer is further configured to split the received unpolarized light into a first and second polarized state. At least two quarter wave phase retarders are configured to convert each of the first and second polarized states to opposite handed polarized beams. A cholesteric mirror is configured to combine the opposite handed polarized beams. In other embodiments, the cholesteric mirror may be replaced by a second polarizer and optional quarter wave retardation plate. Further embodiments may include a single polarization converter and multiple quarter wave retardation plates.