Abstract: This disclosure describes a modular, monolithic pump-purge system which can be integrated into a modular, monolithic fluid handling system without creating a closed tolerance loop. In particular, the pump-purge system comprises a plurality of valves mounted on a modular and monolithic manifold which can be attached to the modular, monolithic fluid handling system. At least a portion, and preferably all of the fluid transfer conduits necessary for either applying a vacuum (or other evacuation means) to a fluid handling system conduit which is to be evacuated (pumped), or for transfer of flushing fluid within a conduit (purging) are present within monolithic manifolds of the fluid handling system. The modular, monolithic manifold of the pump-purge system contains openings and fluid flow conduits which correspond with openings and fluid flow conduits of the modular, monolithic fluid handling system, to enable evacuation or flushing of a selected fluid flow conduit within the fluid handling system.