Patents by Inventor Gary D. Glick

Gary D. Glick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Benzodiazepinone compounds useful in the treatment of skin conditions
    Patent number: 8188072
    Abstract: The present invention provides a family of benzodiazepinone compounds and pharmaceutical compositions thereof. The present invention also provides methods of treating certain skin conditions, e.g., atopic dermatitis, rosacea, or psoriasis, by administering a benzodiazepinone and methods of reducing the proliferation of keratinocyte cells by exposing such cells to a benzodiazepinone.
    Type: Grant
    Filed: November 6, 2008
    Date of Patent: May 29, 2012
    Assignee: The Regents of the University of Michigan
    Inventor: Gary D. Glick
  • Benzodiazepine compositions for treating epidermal hyperplasia and related disorders
    Patent number: 8168626
    Abstract: The present invention provides, for example, pharmaceutical compositions comprising a benzodiazepine compound and an agent selected from the group consisting of a topical steroid, a keratolytic agent, a topical retinoid, a coal tar, and a vitamin D-3 analog. The pharmaceutical compositions are useful for treating medical disorders, such as epidermal hyperplasia.
    Type: Grant
    Filed: March 22, 2010
    Date of Patent: May 1, 2012
    Assignee: The Regents of the University of Michigan
    Inventor: Gary D. Glick
  • 1,4-BENZODIAZEPINONE COMPOUNDS AND THEIR USE IN TREATING CANCER
    Publication number: 20120094982
    Abstract: The invention provides a family of 1,4-benzodiazepinone compounds and methods for their use as therapeutic agents in treating cancer. Pharmaceutical compositions and methods of making the 1,4-benzodiazepinone compounds are provided.
    Type: Application
    Filed: April 16, 2010
    Publication date: April 19, 2012
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Gary D. Glick, Clarke Bentley Taylor, Peter Laurence Toogood, Chad Alan Van Huis
  • NOVEL 1,4-BENZODIAZEPINE-2,5-DIONES WITH THERAPEUTIC PROPERTIES
    Publication number: 20120088757
    Abstract: The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides novel 1,4-benzodiazepine-2,5-dione compounds, and methods of using novel 1,4-benzodiazepine-2,5-dione compounds as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, hyperproliferation, and the like.
    Type: Application
    Filed: December 1, 2011
    Publication date: April 12, 2012
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventor: Gary D. Glick
  • UNSOLVATED BENZODIAZEPINE COMPOSITIONS AND METHODS
    Publication number: 20120077805
    Abstract: The present invention relates to systems and methods for generating new forms of benzodiazepine and benzodiazepine related compounds as well as new compounds and formulations generated by such methods. In particular, the present invention provides high throughput systems and methods for generating and identifying new crystalline benzodiazepine and benzodiazepine related polymorphs and new unsolvated, solvated, and other forms of the compounds that find use as improved drugs and drug formations.
    Type: Application
    Filed: July 21, 2011
    Publication date: March 29, 2012
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Gary D. Glick, Adam Matzger
  • BENZODIAZEPINONE COMPOUNDS USEFUL IN THE TREATMENT OF SKIN CONDITIONS
    Publication number: 20120040971
    Abstract: The present invention provides a family of benzodiazepinone compounds and pharmaceutical compositions thereof. The present invention also provides methods of treating certain skin conditions, e.g., atopic dermatitis, rosacea, or psoriasis, by administering a benzodiazepinone and methods of reducing the proliferation of keratinocyte cells by exposing such cells to a benzodiazepinone.
    Type: Application
    Filed: October 27, 2011
    Publication date: February 16, 2012
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventor: Gary D. Glick
  • Compositions and methods relating to novel compounds and targets thereof
    Patent number: 8097612
    Abstract: The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and related compounds and methods of using benzodiazepine derivatives and related compounds as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, hyperproliferation, and the like.
    Type: Grant
    Filed: June 8, 2007
    Date of Patent: January 17, 2012
    Assignee: The Regents of the University of Michigan
    Inventor: Gary D. Glick
  • 1,4-benzodiazepine-2,5-diones with therapeutic properties
    Patent number: 8088759
    Abstract: The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides novel 1,4-benzodiazepine-2,5-dione compounds, and methods of using novel 1,4-benzodiazepine-2,5-dione compounds as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, hyperproliferation, and the like.
    Type: Grant
    Filed: November 1, 2006
    Date of Patent: January 3, 2012
    Assignee: The Regents of the University of Michigan
    Inventor: Gary D. Glick
  • ARYL GUANIDINE F1F0-ATPASE INHIBITORS AND RELATED METHODS
    Publication number: 20110251200
    Abstract: The invention provides to a family of aryl guanidine-based F1F0-ATPase inhibitors, e.g., mitochondrial F1F0-ATPase inhibitors, methods for their discovery, and their use as therapeutic agents for treating certain disorders.
    Type: Application
    Filed: September 11, 2009
    Publication date: October 13, 2011
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Gary D. Glick, Peter Toogood, Gina Ney
  • Compositions And Methods Relating To Novel Compounds And Targets Thereof
    Publication number: 20110195959
    Abstract: The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine compounds, and structurally and functionally related compounds, and methods of using such compounds as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, hyperproliferation, vascular abnormalities, and the like.
    Type: Application
    Filed: December 7, 2010
    Publication date: August 11, 2011
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventor: Gary D. Glick
  • Unsolvated benzodiazepine compositions and methods
    Patent number: 7994313
    Abstract: The present invention relates to systems and methods for generating new forms of benzodiazepine and benzodiazepine related compounds as well as new compounds and formulations generated by such methods. In particular, the present invention provides high throughput systems and methods for generating and identifying new crystalline benzodiazepine and benzodiazepine related polymorphs and new unsolvated, solvated, and other forms of the compounds that find use as improved drugs and drug formations.
    Type: Grant
    Filed: May 27, 2009
    Date of Patent: August 9, 2011
    Assignee: The Regents of the University of Michigan
    Inventors: Gary D. Glick, Adam Matzger
  • Compositions and methods relating to novel compounds and targets thereof
    Patent number: 7851465
    Abstract: The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine compounds, and structurally and functionally related compounds, and methods of using such compounds as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, hyperproliferation, vascular abnormalities, and the like.
    Type: Grant
    Filed: March 7, 2008
    Date of Patent: December 14, 2010
    Assignee: The Regents of the University of Michigan
    Inventor: Gary D. Glick
  • BENZODIAZEPINE COMPOSITIONS FOR TREATING EPIDERMAL HYPERPLASIA AND RELATED DISORDERS
    Publication number: 20100222310
    Abstract: The present invention provides, for example, pharmaceutical compositions comprising a benzodiazepine compound and an agent selected from the group consisting of a topical steroid, a keratolytic agent, a topical retinoid, a coal tar, and a vitamin D-3 analog.
    Type: Application
    Filed: March 22, 2010
    Publication date: September 2, 2010
    Inventor: Gary D. Glick
  • F1F0-ATPase Inhibitors and Related Methods
    Publication number: 20100222400
    Abstract: The present invention relates to a family of guanidine-based F1F0-ATPase inhibitors, e.g., mitochondrial F1F0-ATPase inhibitors, methods for their discovery, and their use as therapeutic agents for treating certain disorders.
    Type: Application
    Filed: September 11, 2008
    Publication date: September 2, 2010
    Applicant: The Regents of the University of Michigan
    Inventors: Gary D. Glick, Gina Ney
  • Benzodiazepine compositions for treating epidermal hyperplasia and related disorders
    Patent number: 7683046
    Abstract: The present invention provides, for example, pharmaceutical compositions comprising a benzodiazepine compound and an agent selected from the group consisting of a topical steroid, a keratolytic agent, a topical retinoid, a coal tar, and a vitamin D-3 analog. The pharmaceutical compositions are useful for treating medical disorders, such as epidermal hyperplasia.
    Type: Grant
    Filed: April 28, 2008
    Date of Patent: March 23, 2010
    Assignee: The Regents of the University of Michigan
    Inventor: Gary D. Glick
  • COMPOSITIONS AND METHODS RELATING TO NOVEL COMPOUNDS AND TARGETS THEREOF
    Publication number: 20100004227
    Abstract: The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and related compounds and methods of using benzodiazepine derivatives and related compounds as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, hyperproliferation, and the like.
    Type: Application
    Filed: June 8, 2007
    Publication date: January 7, 2010
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventor: Gary D. Glick
  • Compositions and methods relating to novel benzodiazepine compounds and derivatives
    Patent number: 7638624
    Abstract: The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and related compounds and methods of using benzodiazepine derivatives and related compounds as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, hyperproliferation, and the like.
    Type: Grant
    Filed: January 3, 2006
    Date of Patent: December 29, 2009
    Assignee: The Regents of the University of Michigan
    Inventor: Gary D. Glick
  • Methods and compositions for treating diseases and conditions associated with mitochondrial function
    Publication number: 20090275099
    Abstract: The present invention relates to chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides compounds as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, hyperproliferation, mitochondrial F1F0 ATP hydrolase associated disorders, and the like.
    Type: Application
    Filed: March 21, 2007
    Publication date: November 5, 2009
    Applicant: Regents of the University of Michigan
    Inventor: Gary D. Glick
  • UNSOLVATED BENZODIAZEPINE COMPOSITIONS AND METHODS
    Publication number: 20090253686
    Abstract: The present invention relates to systems and methods for generating new forms of benzodiazepine and benzodiazepine related compounds as well as new compounds and formulations generated by such methods. In particular, the present invention provides high throughput systems and methods for generating and identifying new crystalline benzodiazepine and benzodiazepine related polymorphs and new unsolvated, solvated, and other forms of the compounds that find use as improved drugs and drug formations.
    Type: Application
    Filed: May 27, 2009
    Publication date: October 8, 2009
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: Gary D. Glick, Adam Matzger
  • F1F0-ATPASE INHIBITORS AND RELATED METHODS
    Publication number: 20090203734
    Abstract: The present invention relates to inhibitors of mitochondrial F1F0-ATPase, methods for their discovery, and their therapeutic use. In particular, the present invention provides the compound PK11195 and structurally and functionally related compounds as F1F0-ATPase inhibitors, and methods of using such inhibitors as therapeutic agents to treat a number of conditions.
    Type: Application
    Filed: December 29, 2008
    Publication date: August 13, 2009
    Applicant: The Regents of the University of Michigan
    Inventor: Gary D. Glick