Patents by Inventor Gary D. Slade

Gary D. Slade has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and materials for determining pain sensitivity and predicting and treating related disorders
    Patent number: 11085081
    Abstract: Methods of treating somatosensory disorders and modulating production of proinflammatory cytokines by administering to a subject an effective amount of a COMT modulator, ADRB2 modulator, ADRB3 modulator or combinations thereof are provided. Methods of predicting effective pharmacological therapies for a subject afflicted with a somatosensory disorder by determining a genotype of the subject with regard to a gene selected from the group consisting of COMT, ADRB2, ADRB3, and combinations thereof are further provided. Methods of determining pain responses or pain perception and predicting susceptibility of a subject to develop related disorders, such as somatosensory disorders and somatization, by determining a genotype of the subject with regard to a gene selected from the group consisting of COMT, ADRB2, ADRB3, and combinations thereof are further provided.
    Type: Grant
    Filed: May 1, 2018
    Date of Patent: August 10, 2021
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Luda B. Diatchenko, William Maixner, Gary D. Slade, Andrea Gail Neely
  • METHODS AND MATERIALS FOR DETERMINING PAIN SENSITIVITY AND PREDICTING AND TREATING RELATED DISORDERS
    Publication number: 20190010548
    Abstract: Methods of treating somatosensory disorders and modulating production of proinflammatory cytokines by administering to a subject an effective amount of a COMT modulator, ADRB2 modulator, ADRB3 modulator or combinations thereof are provided. Methods of predicting effective pharmacological therapies for a subject afflicted with a somatosensory disorder by determining a genotype of the subject with regard to a gene selected from the group consisting of COMT, ADRB2, ADRB3, and combinations thereof are further provided. Methods of determining pain responses or pain perception and predicting susceptibility of a subject to develop related disorders, such as somatosensory disorders and somatization, by determining a genotype of the subject with regard to a gene selected from the group consisting of COMT, ADRB2, ADRB3, and combinations thereof are further provided.
    Type: Application
    Filed: May 1, 2018
    Publication date: January 10, 2019
    Inventors: Luda B. Diatchenko, William Maixner, Gary D. Slade, Andrea Gail Neely
  • Methods and Materials for Determining Pain Sensitivity and Predicting and Treating Related Disorders
    Publication number: 20130244233
    Abstract: Methods of treating somatosensory disorders and modulating production of proinflammatory cytokines by administering to a subject an effective amount of a COMT modulator, ADRB2 modulator, ADRB3 modulator or combinations thereof are provided. Methods of predicting effective pharmacological therapies for a subject afflicted with a somatosensory disorder by determining a genotype of the subject with regard to a gene selected from the group consisting of COMT, ADRB2, ADRB3, and combinations thereof are further provided. Methods of determining pain responses or pain perception and predicting susceptibility of a subject to develop related disorders, such as somatosensory disorders and somatization, by determining a genotype of the subject with regard to a gene selected from the group consisting of COMT, ADRB2, ADRB3, and combinations thereof are further provided.
    Type: Application
    Filed: September 21, 2012
    Publication date: September 19, 2013
    Applicant: University of North Carolina at Chapel Hill
    Inventors: Luda B. Diatchenko, William Maixner, Gary D. Slade, Andrea Gail Neely