Abstract: The video cassette mailer comprises a box which is foldable from a prescored blank and includes a structure therein for securely isolating at least one video cassette from any damage which it may incur during mailing. The isolating structure is configured to fit snugly within the box and securely engage the video cassette. The isolating structure includes a wall which rests against and cushions one planar surface of the cassette while the box includes a plurality of foldable panels, tabs and cover sections which seat against and cushion the opposite side of the cassette, with the isolating structure protecting at least the short side walls and corners of the cassette.