Abstract: Provided herein are indole derivatives, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.

Abstract: Novel IL-17 like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, selective binding agents, and methods for producing IL-17 like polypeptides. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with IL-17 like polypeptides, agonists, or antagonists thereof.

Abstract: Novel C3b/C4b CR-like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, selective binding agents, and methods for producing C3b/C4b CR-like polypeptides. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with C3b/C4b CR-like polypeptides.

Abstract: The kitchen ladder is adapted and contoured for stable placement against a counter, allowing users to access cabinets without slipping. The ladder has a pair of elongated, parallel side rails and a plurality of parallel steps extending between the side rails. The upper portion of each of the side rails has a recess defined within it that is lined with a strip of non-slipping material. The recesses are adapted to engage a kitchen countertop. The ladder is angled in order to stabilize the ladder against counter edges.

Abstract: Provided herein are indole derivatives, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.

Abstract: Methods and compositions for treating cancers characterized by death-resistant cancer cells are described. In general, such methods involve administration of a therapeutically effective amount of a compound that induces mitotic catastrophe in the some, and preferably most or all, of the cancerous cells. Methods for assessing the efficacy of such treatments are also provided.

Abstract: The present invention provides for IL-17 receptor like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, agonists and antagonists (including selective binding agents), and methods for producing IL-17 receptor like polypeptides. Also provided for are methods for treatment, diagnosis, amelioration, or prevention of diseases with IL-17 receptor like polypeptides.

Abstract: The present invention provides for IL-17 receptor like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, agonists and antagonists (including selective binding agents), and methods for producing IL-17 receptor like polypeptides. Also provided for are methods for treatment, diagnosis, amelioration, or prevention of diseases with IL-17 receptor like polypeptides.

Abstract: The present invention provides for IL-17 receptor like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, agonists and antagonists (including selective binding agents), and methods for producing IL-17 receptor like polypeptides. Also provided for are methods for treatment, diagnosis, amelioration, or prevention of diseases with IL-17 receptor like polypeptides.

Abstract: Stable liquid formulations of the anti-tumor agent L-alanosine are described. These formulations preferably comprise L-alanosine in an aqueous environment having a basic pH, preferably in the range of about pH 8-9. The alanosine formulations and compositions disclosed herein can be used for various purposes, including the treatment of various cancers, particularly those that are deficient in methylthioadenosine phophorylase (MTAP) enzymatic activity. Also described are methods for the treatment of diseases susceptible to treatment with alanosine, e.g., certain cancers, particularly those characterized by tumor cells that are MTAP deficient, wherein a patient is administered L-alanosine, alone or as part of a combination therapy with a second chemotherapeutic agent.

Abstract: Novel C3b/C4b CR-like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, selective binding agents, and methods for producing C3b/C4b CR-like polypeptides. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with C3b/C4b CR-like polypeptides.

Abstract: Methods and compositions for treating or ameliorating diseases and other conditions, such as infectious diseases, autoimmune diseases and allergies are provided. The methods employ mono- and disaccharide-based compounds for selectively stimulating immune responses in animals and plants.

Abstract: Novel IL-17 like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, selective binding agents, and methods for producing IL-17 like polypeptides. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with IL-17 like polypeptides, agonists, or antagonists thereof.

Abstract: Novel IL-17 like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, selective binding agents, and methods for producing IL-17 like polypeptides. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with IL-17 like polypeptides, agonists, or antagonists thereof.

Abstract: Novel IL-17 like polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, selective binding agents, and methods for producing IL-17 like polypeptides. Also provided for are methods for the treatment, diagnosis, amelioration, or prevention of diseases with IL-17 like polypeptides, agonists, or antagonists thereof.

Abstract: Antibodies that interact with interleukin-1 receptor type 1 (IL-1R1) are described. Methods of treating IL-1 mediated diseases by administering a pharmaceutically effective amount of antibodies to IL-1R1 are described. Methods of detecting the amount of IL-1R1 in a sample using antibodies to IL-1R1 are described.

Abstract: A method of generating a compact representation of a digital image is described. A digital image is converted to a square bitmap and divided into a plurality of cells. Each cell is subdivided into a plurality of regions. A minimum intensity region and a maximum intensity region in each cell are identified in each set of the plurality of cells. Cell representation data is generated for each cell in each set of cells based on the positions of the minimum intensity region and the maximum intensity region in the cell. Combining all of the cell representation data in each set of cells for the image creates a compact representation of the original digital image. A method of comparing cell representation data is also described. Cell representation data for a collection of source images is organized into a database. A search of the database identifies candidate images that are at least minimally similar to a target image.

Abstract: A method of producing a mucosal and systemic immune response in a mammal comprising administering sublingually an effective amount of a composition comprising at least one antigen and a glycolipid adjuvant to said mammal.

Abstract: A method of generating a compact representation of a digital image is described, A digital image is converted to a square bitmap and divided into a plurality of cells. Each cell is subdivided into a plurality of regions. A minimum intensity region and a maximum intensity region in each cell are identified in each set of the plurality of cells. Cell representation data is generated for each cell in each set of cells based on the positions of the minimum intensity region and the maximum intensity region in the cell. Combining all of the cell representation data in each set of cells for the image creates a compact representation of the original digital image.

Abstract: An apparatus for transmitting electricity between downhole well tools and the well surface. The apparatus incorporates a surface controller in combination with a conductor and a downhole receiver module. A choke prevents electricity from the controller from entering a high voltage DC power source, and a downhole regulator converts high voltage, low current power into high current, low voltage power. This feature of the invention permits a single wire to transmit sufficient power to operate multiple downhole well tools. The controller also includes a transmitter and a modulator operable to generate an electric signal representating at least two states, wherein a first state is represented by a signal, and wherein a second state is represented by the absence of an electric signal. A receiver module receives the electric signals and selectively transmits commands to the associated well tool or to the surface controller.