Abstract: Machine learning techniques for estimating an indication of carotid-femoral pulse wave velocity (CFPWV) and/or vascular age (VA) of a subject from an arterial waveform previously measured at a single site by an arterial waveform acquisition device coupled to the subject, the method comprising using at least one computer hardware processor to perform: obtaining the arterial waveform, the arterial waveform comprising a plurality of portions corresponding to a respective plurality of heartbeats of the subject; generating a representative heartbeat waveform from the arterial waveform; and providing the representative heartbeat waveform as input to a trained machine learning model to produce a corresponding output indicative of the CFPWV of the subject.

Abstract: A pulse wave velocity measuring device generally comprises first and second photoplethysmographic transducers or probes electrically operably connected to a computer. The transducers are positioned on a patient's back to record pulse waveform information at two locations along the descending thoracic aorta. Additionally, the patient's ECG is recorded. Once the pulse waveforms and ECG waveform are recorded, noise or artifact ridden data is excluded, and the pulse waveforms are signal averaged using the ECG data points as fiducial references. Then, the signal averaged pulse waveforms are analyzed (again, with the ECG data providing fiducial points) to determine the foot of each waveform and the foot-to-foot transit time between the two transducers. Pulse wave velocity is then determined by dividing the distance between the transducers by the foot-to-foot transit time.

Abstract: Methods and compositions are provided for hardening with fast-acting hardeners the colloidal carrier materials, such as gelatin, in the layers of photographic materials, such as photographic film. The methods of the invention comprise coating, with a conventional coating technique, among the layers of a photographic material a layer of a composition of the invention. The compositions of the invention are aqueous solutions which comprise a fast-acting hardener and a polymeric thickener, have concentrations of thickener less than about 50 mg/cm.sup.3 and, at 40.degree. C. and shear rates between about 1000 sec.sup.-1 and 10,000 sec.sup.-1, have viscosities from about 5 cp to about 20 cp and power law indices greater than about 0.90.