Patents by Inventor Gary Firestein

Gary Firestein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modulation of PTPRA to treat arthritis
    Patent number: 10604585
    Abstract: Presented is a method for treating inflammation and autoimmune diseases through the use of a phosphatase rheumatoid arthritis (PT-PRA) antagonist.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: March 31, 2020
    Assignees: La Jolla Institute for Allergy & Immunology, The Regents of the University of California
    Inventors: Nunzio Bottini, Gary Firestein, Stephanie Stanford
  • Puma protein expression vector and use thereof in gene therapy
    Patent number: 10449232
    Abstract: The present invention relates to a viral vector for expression of the cell death-inducing PUMA protein, for use in gene therapy, for example for the treatment of rheumatoid arthritis. This vector consists in particular of a recombinant adenovirus expressing the gene encoding the PUMA protein and of a recombinant baculovirus containing a coxsackie-adenovirus receptor (CAR).
    Type: Grant
    Filed: October 7, 2014
    Date of Patent: October 22, 2019
    Assignees: Hospices Civils de Lyon, The Regents of the University of California, Universite Claude-Bernard-Lyon 1, Institut D'Enseignement Superieur et de Recherche en Alimentation, Sante Animale, Sciences Argonomiques et de l'Environnement, Institut National de la Sante et de la Recherche Medicale
    Inventors: Pierre Miossec, Saw-See Hong, Gary Firestein
  • MODULATION OF PTPRA TO TREAT ARTHRITIS
    Publication number: 20170247469
    Abstract: Presented is a method for treating inflammation and autoimmune diseases through the use of a phosphatase rheumatoid arthritis (PT-PRA) antagonist.
    Type: Application
    Filed: September 9, 2015
    Publication date: August 31, 2017
    Inventors: Nunzio Bottini, Gary Firestein, Stephanie Stanford
  • PUMA PROTEIN EXPRESSION VECTOR AND USE THEREOF IN GENE THERAPY
    Publication number: 20160243194
    Abstract: The present invention relates to a viral vector for expression of the cell death-inducing PUMA protein, for use in gene therapy, for example for the treatment of rheumatoid arthritis. This vector consists in particular of a recombinant adenovirus expressing the gene encoding the PUMA protein and of a recombinant baculovirus containing a coxsackie-adenovirus receptor (CAR).
    Type: Application
    Filed: October 7, 2014
    Publication date: August 25, 2016
    Applicants: Hospices Civils de Lyon, The Regents of the University of California, Universite Claude Bernard-Lyon 1, Institut d'Enseignement Superieur et de Recherche en Alimentation, Sante Animale, Sciences Agronomiq, Institut National de la Sante et de la Recherche Medicale (INSERM)
    Inventors: Pierre MIOSSEC, Saw-See HONG, Gary FIRESTEIN
  • Diagnosis and treatment of arthritis using epigenetics
    Publication number: 20130129668
    Abstract: Embodiments of the present invention include methods, compositions and kits for evaluating a diagnosis, prognosis, or response to treatment of a subject with a disorder such as rheumatoid arthritis or osteoarthritis. Some embodiments include identifying a therapeutic agent for treating a disorder such as rheumatoid arthritis or osteoarthritis.
    Type: Application
    Filed: August 31, 2012
    Publication date: May 23, 2013
    Applicant: The Regents of the University of California
    Inventors: Gary Firestein, Kazuhisa Nakano
  • THERAPY FOR CELLULAR ACCUMULATION IN CHRONIC INFLAMMATORY DISEASES
    Publication number: 20080044465
    Abstract: The present invention provides a novel method for the treatment of cellular accumulation in chronic inflammatory diseases such as rheumatoid arthritis. The method includes gene delivery and gene expression that is capable of enhancing apoptosis of accumulating cells and those cells which recruit accumulating cells. Also provided are diagnostic methods for detecting cellular accumulation diseases.
    Type: Application
    Filed: August 28, 2007
    Publication date: February 21, 2008
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Gary Firestein, Nathan Zvaifler, Douglas Green
  • Inducing expression of puma to reduce joint inflammation in the treatment of arthritis
    Publication number: 20070065421
    Abstract: It has been discovered the BH3-only proapoptotic Bcl-2 proteins like PUMA (the p53 upregulated modulator of apoptosis) can be activated in fibroblast-like synoviocytes present in the joints of subjects with rheumatoid arthritis. This bypasses the p53 apoptotic pathway, which normally clears FLS fomr the joints, but is often defective in arthritis. Suitable therapeutic agents of this invention include gene vectors that cause increased expression of BH3-only proapoptotic proteins in target cells. These agents are formulated in pharmaceutical compositions for administration directly to joint. Reestablishing apoptosis in synoviocytes decreases their pro-inflammatory and destrcutive activity, improving the clinical condition.
    Type: Application
    Filed: September 15, 2006
    Publication date: March 22, 2007
    Inventors: Gary Firestein, David Boyle