Abstract: The disclosure relates to modulating pyruvate kinase and provides novel chemical compounds useful as activators of PKR, as well as various uses of these compounds. PKR activating compounds are useful in the treatment of diseases and disorders associated with PKR and/or PKM2, such as pyruvate kinase deficiency (PKD), sickle cell disease (SCD), and thalassemia.

Abstract: The compound (S)-1-(5-((2,3-dihydro-[1,4]dioxino[2,3-b]pyridin-7-yl)sulfonyl)-3,4,5,6-tetrahydropyrrolo[3,4-c]pyrrol-2(1H)-yl)-3-hydroxy-2-phenylpropan-1-one, or a pharmaceutically acceptable salt thereof, is useful to increase the affinity of hemoglobin for oxygen. Methods and compositions for the treatment of a hemoglobinopathies are provided herein, including certain pharmaceutical compositions for activating PKR.

Abstract: The disclosure provides novel chemical compounds useful as activators of PKR. PKR activating compounds are useful in the treatment of disease and disorders associated with modulation of PKR and/or PKM2, such as pyruvate kinase deficiency (PKD).

Abstract: The disclosure relates to modulating pyruvate kinase and provides novel chemical compounds useful as activators of PKR, as well as various uses of these compounds. PKR activating compounds are useful in the treatment of diseases and disorders associated with PKR and/or PKM2, such as pyruvate kinase deficiency (PKD), sickle cell disease (SCD), and thalassemia.

Abstract: Compounds that activate pyruvate kinase R can be used for the treatment of sickle cell disease (SCD). Methods and compositions for the treatment of SCD are provided herein, including a therapeutic compound designated as Compound 1.

Abstract: The embodied invention is a multi-vault memorial facility with a memorial room and an interactive system for storing and providing memorial information of the deceased. The meeting room includes memorabilia and access to a secure personal biographical database which includes historical and personal information about the deceased. An interactive user interface for a visiting person is used when at the facility. The personal biography database security is provided by administration control for access and identifies who can modify the database. The interactive user interface utilizes visual and audio presentations, and a conversational user interface with a likeness and a digital memory of the deceased. A computer projection talks with a visitor and mimics responses of the deceased.

Abstract: An interment system, includes: (a) at least one desiccation vessel for storing remains of a decedent who has not been cremated; (b) a plurality of memorial suites configured to house the at least one desiccation vessel, each of which includes a storage area for the at least one desiccation vessel, a living area, a vertically-oriented tribute wall separating the storage area from the living area, and an HVAC unit, which is configured to adjust at least one of a temperature, a pressure and a humidity within the at least one desiccation vessel to adjust a rate of desiccation; (c) a processor configured to securely store and share decedent data. The at least one desiccation vessel is sufficiently light, durable, and air-tight such that the at least one desiccation vessel with the decedent contained therein can be easily relocated without the need for special vehicles or trained personnel.

Abstract: An interment system, includes: (a) at least one desiccation vessel for storing remains of a decedent who has not been cremated; (b) a plurality of memorial suites configured to house the at least one desiccation vessel, each of which includes a storage area for the at least one desiccation vessel, a living area, a vertically-oriented tribute wall separating the storage area from the living area, and an HVAC unit, which is configured to adjust at least one of a temperature, a pressure and a humidity within the at least one desiccation vessel to adjust a rate of desiccation; (c) a processor configured to securely store and share decedent data. The at least one desiccation vessel is sufficiently light, durable, and air-tight such that the at least one desiccation vessel with the decedent contained therein can be easily relocated without the need for special vehicles or trained personnel.

Abstract: The embodied invention is a multi-vault memorial facility with a memorial room and an interactive system for storing and providing memorial information of the deceased. The meeting room includes memorabilia and access to a secure personal biographical database which includes historical and personal information about the deceased. An interactive user interface for a visiting person is used when at the facility. The personal biography database security is provided by administration control for access and identifies who can modify the database. The interactive user interface utilizes visual and audio presentations, and a conversational user interface with a likeness and a digital memory of the deceased. A computer projection talks with a visitor and mimics responses of the deceased.

Abstract: A memorial suite provides a safe and comfortable place for surviving family members, friends, and loved ones to mourn, research and visit decedents. The memorial suite takes advantage of air space rather than burying caskets containing human remains in the ground. A storage area is provided within the memorial suite that includes horizontal shelves that support receptacles thereon. Each receptacle is provided for storing interment vessels or air-tight caskets containing remains of the decedent. A tribute wall may include plaques bearing images and descriptive information about the decedents. The memorial suite may include some or all of the comforts of a living room and other rooms within a family home.

Abstract: The online method for managing scheduling of, payment for and accounting of a medical management transaction available over a global system for a patient and a health care provider, includes providing a database server, providing an application server on which the medical management system resides, providing payment processing services, exchanging regulated data with a medical services government agency, accessing electronic medical records services by the patient, including uploading existing medical records by the health care provider and the patient, commenting on accessed records by the patient to provide patient comments, storing the patient comments in the system and providing the patient comments to the health care provider along with records requested by the health care provider.

Abstract: Systems and methods to support an electronic market place include a communication network to communicate purchase requests; one or more buyers coupled to the network to issue a purchase order specifying items from two or more suppliers; and a server coupled to the network to receive the purchase order, the server generating sub-orders from the purchase order and sending the sub-orders to the two or more suppliers for fulfillment.

Abstract: Systems and methods to support an electronic market place include a communication network to communicate purchase requests; one or more buyers coupled to the network to issue a purchase order specifying items from two or more suppliers; and a server coupled to the network to receive the purchase order, the server generating sub-orders from the purchase order and sending the sub-orders to the two or more suppliers for fulfillment.

Abstract: Compositions and methods for the treatment or prevention of gallbladder disease are provided. In particular, pharmaceutical compositions containing an amount of serine proteinase inhibitor such as potato proteinase inhibitor II effective to induce gallbladder contraction in a host are provided. The compositions can be administered to individuals having a body mass index of at least 25 during rapid weight loss or during a weight loss regime.

Abstract: An apparatus that may be configured to generate a wireless radio signal in response to one or more first data signals. The wireless radio signal may comprise a single frequency hopping sequence configured to support one or more peripheral wireless network devices. The apparatus may also be configured to generate the one or more first data signals in response to the wireless radio signal.

Abstract: One embodiment disclosed relates to a method for sealing an active area of a surface acoustic wave (SAW) device on a wafer. The method includes providing a sacrificial material over at least the active area of the SAW device, depositing a seal coating over the wafer so that the seal coating covers the sacrificial material, and replacing the sacrificial material with a target atmosphere. Another embodiment disclosed relates to an SAW device sealed at the wafer level (i.e. prior to separation of the die from the wafer). The device includes an active area to be protected, an electrical contact area, and a lithographically-formed structure sealing at least the active area and leaving at least a portion of the electrical contact area exposed.

Abstract: One embodiment disclosed relates to a method for sealing an active area of a surface acoustic wave (SAW) device on a wafer. The method includes providing a sacrificial material over at least the active area of the SAW device, depositing a seal coating over the wafer so that the seal coating covers the sacrificial material, and replacing the sacrificial material with a target atmosphere. Another embodiment disclosed relates to an SAW device sealed at the wafer level (i.e. prior to separation of the die from the wafer). The device includes an active area to be protected, an electrical contact area, and a lithographically-formed structure sealing at least the active area and leaving at least a portion of the electrical contact area exposed.

Abstract: Customizing products and services offered by an out-of-home vacation provider to a customer's personal preferences includes creating a customer profile. Data about a customer's preferences is collected. The collected data is stored in the customer profile, and using a decision tree customizes the customer's vacation experience based on the collected data.

Abstract: An apparatus that may be configured to generate a wireless radio signal in response to one or more first data signals. The wireless radio signal may comprise a single frequency hopping sequence configured to support one or more peripheral wireless network devices. The apparatus may also be configured to generate the one or more first data signals in response to the wireless radio signal.

Abstract: An apparatus that may be configured to generate a wireless radio signal in response to one or more first data signals. The wireless radio signal may comprise a single frequency hopping sequence configured to support one or more peripheral wireless network devices. The apparatus may also be configured to generate the one or more first data signals in response to the wireless radio signal.