Abstract: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, and 7-aza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.

Abstract: In some examples, a delay apparatus includes a controllable delay line comprising a plurality of delay elements selectively connected in a signal path to vary a delay of a signal passing through the delay line, and a controllable phase shifter comprising reflective loads adjustable to vary a phase shift applied to the signal.

Abstract: System and method embodiments are provided for analog cancellation for division free duplexing for radios using MIMO. In an embodiment, a system for minimizing transmitted signals from a transmitter appearing at a co-located receiver in a division free duplexing radio includes a transmitter to transmit an analog transmitted signal; an antenna; a circulator coupled to the transmitter and the antenna; a tuning algorithm component configured to receive a copy of the analog transmitted signal from the transmitter and a sampled analog received signal from a received signal path from the circulator, wherein the sampled analog received signal is sampled at a point in the received signal path before the analog received signal is provided to a receiver; and a multitap cancellation component configured to provide a cancellation signal to couple to the analog received signal such that an amount of the analog transmitted signal appearing at the receiver is reduced.

Abstract: Various arrangements of a PIN diode attenuator circuit are presented. The PIN diode attenuator circuit may include a quadrature hybrid coupler. The PIN diode attenuator circuit may include a direct current (DC) feed circuit comprising an adjustable DC voltage source. PIN diode attenuator circuit may include first and second PIN diode circuits connected with ports of the quadrature hybrid coupler. Each PIN diode circuit may include a PIN diode having a first cathode of the first PIN diode directly connected to a ground potential and a first anode of the first PIN diode connected with the DC feed circuit and the quadrature hybrid coupler.

Abstract: In some examples, a delay apparatus includes a controllable delay line comprising a plurality of delay elements selectively connected in a signal path to vary a delay of a signal passing through the delay line, and a controllable phase shifter comprising reflective loads adjustable to vary a phase shift applied to the signal.

Abstract: A tapped delay line channel model may be employed to suppress the self-interference that is introduced, at a receiver input, by a signal at a transmitter output. The self-interference may be considered to have components introduced by the internal antenna subsystem of a full duplex MIMO transceiver.

Abstract: A tapped delay line channel model may be employed to suppress the self-interference that is introduced, at a receiver input, by a signal at a transmitter output. The self-interference may be considered to have components introduced by the internal antenna subsystem of a full duplex MIMO transceiver.

Abstract: Disclosed herein are an analog compensation circuit and a method for tuning an analog compensator in full-duplex transmission systems. An embodiment analog compensation circuit includes a secondary receiver configured to receive and convert a sampled self-interference signal to a baseband self-interference signal. A tuner is coupled to the secondary receiver and configured to receive a baseband transmit signal and the baseband self-interference signal, and to compute complex gains according to the baseband transmit signal and the baseband self-interference signal. An analog compensator is coupled to the tuner and has multiple branches. The analog compensator is configured to receive the complex gains and use them to adjust respective attenuators and phase shifters of the branches. The analog compensator is further configured to process a sample of a transmit signal using the branches, the transmit signal being up-converted from a new baseband transmit signal.

Abstract: A system and method for leak suppression in a full duplex system is disclosed. In an embodiment, a system for wireless transmission and reception includes a circulator having a common port, an input port and an output port; a conjugate matching tuner coupled to the common port; and an antenna coupled to the conjugate matching tuner, an impedance of the antenna being conjugate matched to an impedance of the common port of the circulator by the conjugate matching tuner.

Abstract: System and method embodiments are provided for analog cancellation for division free duplexing for radios using MIMO. In an embodiment, a system for minimizing transmitted signals from a transmitter appearing at a co-located receiver in a division free duplexing radio includes a transmitter to transmit an analog transmitted signal; an antenna; a circulator coupled to the transmitter and the antenna; a tuning algorithm component configured to receive a copy of the analog transmitted signal from the transmitter and a sampled analog received signal from a received signal path from the circulator, wherein the sampled analog received signal is sampled at a point in the received signal path before the analog received signal is provided to a receiver; and a multitap cancellation component configured to provide a cancellation signal to couple to the analog received signal such that an amount of the analog transmitted signal appearing at the receiver is reduced.

Abstract: Disclosed herein are an analog compensation circuit and a method for tuning an analog compensator in full-duplex transmission systems. An embodiment analog compensation circuit includes a secondary receiver configured to receive and convert a sampled self-interference signal to a baseband self-interference signal. A tuner is coupled to the secondary receiver and configured to receive a baseband transmit signal and the baseband self-interference signal, and to compute complex gains according to the baseband transmit signal and the baseband self-interference signal. An analog compensator is coupled to the tuner and has multiple branches. The analog compensator is configured to receive the complex gains and use them to adjust respective attenuators and phase shifters of the branches. The analog compensator is further configured to process a sample of a transmit signal using the branches, the transmit signal being up-converted from a new baseband transmit signal.

Abstract: Disclosed herein are an analog compensation circuit and a method for tuning an analog compensator in full-duplex transmission systems. An embodiment analog compensation circuit includes a secondary receiver configured to receive and convert a sampled self-interference signal to a baseband self-interference signal. A tuner is coupled to the secondary receiver and configured to receive a baseband transmit signal and the baseband self-interference signal, and to compute complex gains according to the baseband transmit signal and the baseband self-interference signal. An analog compensator is coupled to the tuner and has multiple branches. The analog compensator is configured to receive the complex gains and use them to adjust respective attenuators and phase shifters of the branches. The analog compensator is further configured to process a sample of a transmit signal using the branches, the transmit signal being up-converted from a new baseband transmit signal.

Abstract: An apparatus is presented for providing alignment to a pipe or conduit extending through a floor, wall or ceiling, comprising a box-like housing having a first set of one or more openings extending therethrough, one or more pipe stubs for extending through the first set of openings for receiving partially therein the pipe or conduit, and elastomeric members for securing the pipe stubs within the openings of the housing and to provide a fluid-tight seal therebetween. The alignment device is adapted for positioning within a floor, wall or ceiling. The number, location and size of the openings can be varied to accommodate various piping systems, and may be determined on a case- by-case basis prior to construction, relying on customized or standardized pipe fittings. Other embodiments may consist of multiple openings of various dimensions, aligned in the center of the housing or in combinations suitable for specific pipes and other variations.

Abstract: An apparatus is presented for providing vertical or horizontal alignment to a pipe or conduit extending through a floor, wall or ceiling surface, comprising a box-like housing having a first set of one or more openings extending therethrough, one or more pipe stubs for extending through the first set of one or more openings of the housing for receiving partially therein the pipe or conduit, and elastomeric members for securing the pipe stubs within the openings of the housing and to provide a fluid-tight seal therebetween. The alignment device is adapted to be positioned within the floor, wall or ceiling surface, respectively, through which the pipe or conduit is to extend. The number, location and size of the stub openings can be varied to accommodate piping systems of varying sizes and configurations, and may be determined on a case-by-case basis prior to construction, relying on customized pipe fittings as well as standardized models for masonry construction and wood-frame construction.

Abstract: The present invention is directed to methods for treating cancer wherein more than one therapeutic agent is used, with each of the therapeutic agents having different tumor-killing capabilities, and wherein the therapeutic agents are delivered to the tumor sites using combined targeting and pre-targeting methods. The methods of the present invention achieve good tumor to non-tumor ratios of the therapeutic agents, and are effective for cancer therapy.

Abstract: Embodiments of the invention relate to a method for treating target cells, tissues or pathogens in a subject, comprising administering a non-covalently bound complex which comprises a multispecific targeting protein and a hapten-enzyme covalent conjugate, followed by administration of a prodrug that is converted to an active drug by the enzyme. Other embodiments of the invention further relate to kits comprising the non-covalently bound complex or the components to prepare the complex.

Abstract: The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that is reactive against a targeted tissue and at least one other arm that is reactive against a linker moiety. The linker moiety encompasses a hapten to which antibodies have been prepared. The antigenic linker is conjugated to one or more therapeutic or diagnostic agents or enzymes. The invention provides constructs and methods for producing the bispecific antibodies or antibody fragments, as well as methods for using them.

Abstract: The present invention is directed to methods for treating cancer wherein more than one therapeutic agent is used, with each of the therapeutic agents having different tumor-killing capabilities, and wherein the therapeutic agents are delivered to the tumor sites using combined targeting and pre-targeting methods. The methods of the present invention achieve good tumor to non-tumor ratios of the therapeutic agents, and are effective for cancer therapy.

Abstract: The invention relates to therapeutic conjugates with the ability to target various antigens. The conjugates contain a targeting antibody or antigen binding fragment thereof and an anthracycline chemotherapeutic drug. The targeting antibody and the chemotherapeutic drug are linked via a linker comprising a hydrazide moiety.

Abstract: Improved synthesis methods are provided for preparing conjugates of proteins and chelating agents. In the synthesis methods, non-stable bonds are hydrolyzed after the conjugate is synthesized, for example by treating the conjugate with a quenching agent. The synthesis method provides conjugates that are substantially free of non-stable bonds between the protein and the chelating agent, such that the chelating agent is less likely to dissociate with the conjugate after the conjugate has been stored for extended periods. The conjugate may be useful for therapeutic or diagnostic methods.