Patents by Inventor Gary H. Birnberg

Gary H. Birnberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of using 5-(arysulfonyl)-, 5-(arylsulfanyl)-and 5-(arylsulfanyl)thiazolidine-2,4-diones for inhibition of farnesyl-protein transferase
    Patent number: 6605628
    Abstract: This invention relates to a method of using novel 5-(arylsulfonyl)-5-(arylsulfinyl)- and 5-(arylsulfanyl)thiazolidine-2,4-diones of Formula (I), wherein Ar, Ar′, R6, m and n are as defined in the specification as inhibitors of Ras FPTase, and may be used as an alternative to, or in conjunction with, traditional cancer therapy for treating ras- oncogene-dependent tumors, such as cancers of the pancreas, colon, bladder, and thyroid
    Type: Grant
    Filed: August 23, 2002
    Date of Patent: August 12, 2003
    Assignee: Wyeth Holdings Corporation
    Inventors: Semiramis Ayral-Kaloustian, Joseph William Epstein, Gary H. Birnberg, Edward James Salaski, Gloria Jean Macewan, Katherine Cheung
  • Method of using 5-(arysulfonyl)-, 5-(arylsulfanyl)-and 5-(arylsulfanyl)thiazolidine-2,4-diones for inhibition of farnesyl-protein transferase
    Publication number: 20030144301
    Abstract: This invention relates to a method of using novel 5-(arylsulfonyl)-, 5-(arylsulfinyl)- and 5-(arylsulfanyl)thiazolidine-2,4-diones of Formula (1), wherein Ar, Ar′, R6, m and n are as defined in the specification as inhibitors of Ras FPTase, and may be used as an alternative to, or in conjunction with, traditional cancer therapy for treating ras- oncogene-dependent tumors, such as cancers of the pancreas, colon, bladder, and thyroid.
    Type: Application
    Filed: August 23, 2002
    Publication date: July 31, 2003
    Applicant: American Cyanamid Company
    Inventors: Semiramis Ayral-Kaloustian, Joseph William Epstein, Gary H. Birnberg, Edward James Salaski, Gloria Macewan, Katherine Cheung
  • .beta..sub.3 -adrenergic agents, benzodioxole dicarboxylates and their use in pharmaceutical compositions
    Patent number: 5606069
    Abstract: The invention is antiobesity/antidiabetes beta-3 agonists of the formula: ##STR1## wherein Ar, X, R.sub.2, R.sub.3, Y and n are as defined in the specification.
    Type: Grant
    Filed: May 23, 1995
    Date of Patent: February 25, 1997
    Assignee: American Cyanamid Company
    Inventors: Joseph W. Epstein, Gary H. Birnberg, Minu D. Dutia, Thomas H. Claus, Elwood E. Largis
  • Aminocycloalkanobenzodioxoles as beta-3 selective adrenergic agents
    Patent number: 5594027
    Abstract: The invention is antiobesity/antidiabetic/beta-3 agonists of the formula ##STR1## wherein the substituents R.sub.o, R.sub.1, R.sub.4, R.sub.4 ', R.sub.5, R.sub.6 or n are as defined in the specification.
    Type: Grant
    Filed: May 5, 1995
    Date of Patent: January 14, 1997
    Assignee: American Cyanamid Company
    Inventors: Joseph W. Epstein, Gary H. Birnberg, Gary E. Walker, Minu D. Dutia, Jonathan D. Bloom
  • Aminocycloalkanobenzodioxoles as beta-3 selective adrenergic agents
    Patent number: 5510376
    Abstract: The invention is antiobesity/antidiabetic/beta-3 agonists of the formula ##STR1## wherein the substituents R.sub.o, R.sub.1, R.sub.4, R.sub.4 ', R.sub.5, R.sub.6 or n are as defined in the specification.
    Type: Grant
    Filed: May 27, 1994
    Date of Patent: April 23, 1996
    Assignee: American Cyanamid Company
    Inventors: Joseph W. Epstein, Gary H. Birnberg, Gary E. Walker, Minu D. Dutia, Jonathan D. Bloom
  • Beta.sub.3 -adrenergic agents and their use in pharmaceutical compositions
    Patent number: 5482971
    Abstract: This invention is concerned with novel compounds of formula I: ##STR1## which are selective beta.sub.3 -adrenergic agents.
    Type: Grant
    Filed: October 1, 1993
    Date of Patent: January 9, 1996
    Assignee: American Cyanamid Company
    Inventors: Joseph W. Epstein, Gary H. Birnberg, Feng L. Qing
  • .beta..sub.3 -adrenergic agents benzodioxole dicarboxylates and their use in pharmaceutical compositions
    Patent number: 5480908
    Abstract: The invention is antiobesity/antidiabetes beta-3 agonists of the formula: ##STR1## wherein Ar, X, R.sub.2, R.sub.3, Y and n are as defined in the specification.
    Type: Grant
    Filed: December 13, 1993
    Date of Patent: January 2, 1996
    Assignee: American Cyanamid Company
    Inventors: Joseph W. Epstein, Gary H. Birnberg, Minu D. Dutia, Thomas H. Claus, Elwood E. Largis
  • Substituted guanidinedicarbonyl derivatives
    Patent number: 4977189
    Abstract: This disclosure describes novel substituted guanidinedicarbonyl derivatives which possess anxiolytic activity and are also useful as agents for the treatment of cognitive and related neural behavioral problems in mammals.
    Type: Grant
    Filed: July 11, 1988
    Date of Patent: December 11, 1990
    Assignee: American Cyanamid Company
    Inventors: Andrew S. Tomcufcik, James S. Dixon, Joseph W. Epstein, Gary H. Birnberg, William J. Fanshawe
  • .omega.-Heteroaroyl(propionyl or butyryl)-L-prolines
    Patent number: 4342690
    Abstract: This disclosure describes novel substituted .omega.-heteroaroyl(propionyl or butyryl)-L-prolines and the esters and cationic salts thereof which are useful as hypotensive agents in mammals.
    Type: Grant
    Filed: March 11, 1981
    Date of Patent: August 3, 1982
    Assignee: American Cyanamid Company
    Inventors: Francis J. McEvoy, William B. Wright, Jr., Gary H. Birnberg, Jay D. Albright
  • .omega.-Heteroaroyl(propionyl or butyryl)-L-prolines
    Patent number: 4342691
    Abstract: This disclosure describes novel substituted .omega.-heteroaroyl(propionyl or butyryl)-L-prolines and the esters and cationic salts thereof which are useful as hypotensive agents in mammals.
    Type: Grant
    Filed: March 11, 1981
    Date of Patent: August 3, 1982
    Assignee: American Cyanamid Company
    Inventors: Francis J. McEvoy, William B. Wright, Jr., Gary H. Birnberg, Jay D. Albright
  • .omega.-Heteroaroyl(propionyl or butyryl)-L-prolines
    Patent number: 4342689
    Abstract: This disclosure describes novel substituted .omega.-heteroaroyl(propionyl or butyryl)-L-prolines and the esters and cationic salts thereof which are useful as hypotensive agents in mammals.
    Type: Grant
    Filed: March 11, 1981
    Date of Patent: August 3, 1982
    Assignee: American Cyanamid Company
    Inventors: Francis J. McEvoy, William B. Wright, Jr., Gary H. Birnberg, Jay D. Albright
  • .omega.-Heteroaroyl(propionyl or butyryl)-L-prolines
    Patent number: 4299769
    Abstract: This disclosure describes novel substituted .omega.-heteroaroyl(propionyl or butyryl)-L-prolines and the esters and cationic salts thereof which are useful as hypotensive agents in mammals.
    Type: Grant
    Filed: April 28, 1980
    Date of Patent: November 10, 1981
    Assignee: American Cyanamid Company
    Inventors: Francis J. McEvoy, William B. Wright, Jr., Gary H. Birnberg, Jay D. Albright