Patents by Inventor Gary Hattersley

Gary Hattersley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR TREATING CANCER
    Publication number: 20240099996
    Abstract: Disclosed herein are methods of inhibiting tumor growth or producing tumor regression in a subject having a drug-resistant estrogen receptor alpha positive cancer or a mutant estrogen receptor alpha positive cancer. The methods entail administering to the subject a therapeutically effective amount of RAD1901 having the structure: or a salt or solvate thereof.
    Type: Application
    Filed: September 12, 2023
    Publication date: March 28, 2024
    Inventors: Fiona GARNER, Gary Hattersley
  • METHODS FOR TREATING CANCER
    Publication number: 20240091177
    Abstract: Disclosed herein are methods of treating one or more tumors by administering to the subject a therapeutically effective amount of a combination of RAD1901 or solvates (e.g., hydrate) or salts thereof and one or more second therapeutic agent(s) (e.g., everolimus). The cancer is an estrogen-dependent cancer, such as breast cancer, ovarian cancer, colon cancer, endometrial cancer, or prostate cancer.
    Type: Application
    Filed: November 16, 2023
    Publication date: March 21, 2024
    Inventor: Gary HATTERSLEY
  • Methods for treating cancer
    Patent number: 11857518
    Abstract: Disclosed herein are methods of treating one or more tumors by administering to the subject a therapeutically effective amount of a combination of RAD1901 or solvates (e.g., hydrate) or salts thereof and one or more second therapeutic agent(s) (e.g., everolimus). The cancer is an estrogen-dependent cancer, such as breast cancer, ovarian cancer, colon cancer, endometrial cancer, or prostate cancer.
    Type: Grant
    Filed: October 25, 2021
    Date of Patent: January 2, 2024
    Assignee: RADIUS PHARMACEUTICALS, INC.
    Inventor: Gary Hattersley
  • USES OF PTHrP ANALOGUE IN REDUCING FRACTURE RISK
    Publication number: 20230381283
    Abstract: Disclosed herein are PTHrP or analogues thereof, such as abaloparatide, for preventing or reducing bone fractures in subjects in need thereof, as well as methods of using PTHrP or analogues thereof to prevent or reduce bone fractures. Also disclosed are PTHrP or analogues thereof, such as abaloparatide, for increasing BMD and/or TBS in subjects in need thereof, as well as methods of using PTHrP or analogues thereof to increase BMD and/or TBS.
    Type: Application
    Filed: April 6, 2023
    Publication date: November 30, 2023
    Applicant: Radius Health, Inc.
    Inventor: Gary Hattersley
  • Methods for treating cancer
    Patent number: 11819480
    Abstract: Disclosed herein are methods of inhibiting tumor growth or producing tumor regression in a subject having a drug-resistant estrogen receptor alpha positive cancer or a mutant estrogen receptor alpha positive cancer. The methods entail administering to the subject a therapeutically effective amount of RAD1901 having the structure: or a salt or solvate thereof.
    Type: Grant
    Filed: August 4, 2020
    Date of Patent: November 21, 2023
    Assignee: RADIUS PHARMACEUTICALS, INC.
    Inventors: Fiona Garner, Gary Hattersley
  • METHODS OF STIMULATING BONE GROWTH WITH ABALOPARATIDE AND DENOSUMAB
    Publication number: 20230330191
    Abstract: Provided herein are methods for increasing bone mineral density, treating osteoporosis and the like, that include administration of abaloparatide in combination with denosumab.
    Type: Application
    Filed: July 22, 2022
    Publication date: October 19, 2023
    Applicant: Radius Health, Inc.
    Inventors: Gary Hattersley, John A. Yates, Bruce Mitlak
  • USES OF PTHrP ANALOGUE IN REDUCING FRACTURE RISK
    Publication number: 20230321199
    Abstract: Disclosed herein are PTHrP or analogues thereof, such as abaloparatide, for preventing or reducing bone fractures in subjects in need thereof, as well as methods of using PTHrP or analogues thereof to prevent or reduce bone fractures. Also disclosed are PTHrP or analogues thereof, such as abaloparatide, for increasing BMD and/or TBS in subjects in need thereof, as well as methods of using PTHrP or analogues thereof to increase BMD and/or TBS.
    Type: Application
    Filed: May 19, 2023
    Publication date: October 12, 2023
    Applicant: Radius Health, Inc.
    Inventor: Gary Hattersley
  • AR+ breast cancer treatment methods
    Patent number: 11771682
    Abstract: A method for treating AR+ breast cancer in a subject comprising administering to the subject an AR agonist (e.g., SARMs such as RAD140), or in combination with one or more therapeutic agents selected from the group consisting of cdk4/6 inhibitors, m-TOR inhibitors, PI3k inhibitors, PARP inhibitors, BCL-2 inhibitors, and MCL-1 inhibitors.
    Type: Grant
    Filed: November 26, 2019
    Date of Patent: October 3, 2023
    Assignee: Ellipses Pharma Ltd.
    Inventors: Gary Hattersley, Jamal Saeh, Ziyang Yu, Chris Miller, Teeru Bihani
  • FORMULATIONS OF PTHrP ANALOGUES, TRANSDERMAL PATCHES THEREOF, AND USES THEREOF
    Publication number: 20230277444
    Abstract: Disclosed are PTHrP analogue formulations for transdermal delivery of a therapeutically effective amount of a PTHrP analogue, as well as transdermal patches prepared using these formulations, methods of preparing the disclosed formulations and patches, and methods of using these formulations and patches to treat osteoporosis, osteopenia, osteoarthritis, and/or bone fracture, improve bone mineral density (BMD), improve trabecular bone score (TBS), and treat, prevent, and/or reduce bone fractures.
    Type: Application
    Filed: November 4, 2022
    Publication date: September 7, 2023
    Applicants: Radius Health, Inc., Kindeva Drug Delivery L.P.
    Inventors: Gary Hattersley, Alan Harris, Jamal Saeh, Ehab Hamed, Kenneth Brown, Daniel Dohmeier, Joan Moseman, Ying Zhang, Lisa Dick
  • METHODS FOR TREATING OVARIAN CANCER
    Publication number: 20230129787
    Abstract: Methods of treating ovarian cancer are disclosed.
    Type: Application
    Filed: December 27, 2022
    Publication date: April 27, 2023
    Inventor: Gary HATTERSLEY
  • TREATING CANCERS WITH A CYCLIN-DEPENDENT KINASE INHIBITOR
    Publication number: 20230000876
    Abstract: The present disclosure relates to methods of treating cancers, including metastasized cancers by administering a potent CDK 2/4/6 inhibitor of the formula (I), or a pharmaceutically acceptable salt thereof, to a patient in need thereof.
    Type: Application
    Filed: June 8, 2022
    Publication date: January 5, 2023
    Inventors: Teeru BIHANI, Gary HATTERSLEY, Chris P. MILLER, Hitisha PATEL, Sergey YURASOV, Yan ZHANG
  • METHODS FOR TREATING CANCER
    Publication number: 20220339126
    Abstract: Disclosed herein are methods of inhibiting tumor growth or producing tumor regression in a subject by administering to the subject a therapeutically effective amount of a combination of palbociclib and RAD1901.
    Type: Application
    Filed: June 29, 2022
    Publication date: October 27, 2022
    Inventor: Gary HATTERSLEY
  • Methods for treating cancer
    Patent number: 11413258
    Abstract: Disclosed herein are methods of inhibiting tumor growth or producing tumor regression in a subject by administering to the subject a therapeutically effective amount of a combination of palbociclib and RAD1901.
    Type: Grant
    Filed: September 24, 2019
    Date of Patent: August 16, 2022
    Assignee: Radius Pharmaceuticals, Inc.
    Inventor: Gary Hattersley
  • USES OF PTHrP ANALOGUE IN REDUCING FRACTURE RISK
    Publication number: 20220125887
    Abstract: Disclosed herein are PTHrP or analogues thereof, such as abaloparatide, for preventing or reducing bone fractures in subjects in need thereof, as well as methods of using PTHrP or analogues thereof to prevent or reduce bone fractures. Also disclosed are PTHrP or analogues thereof, such as abaloparatide, for increasing BMD and/or TBS in subjects in need thereof, as well as methods of using PTHrP or analogues thereof to increase BMD and/or TBS.
    Type: Application
    Filed: September 10, 2021
    Publication date: April 28, 2022
    Applicant: Radius Health, Inc.
    Inventor: Gary Hattersley
  • METHODS FOR TREATING CANCER
    Publication number: 20220110890
    Abstract: Disclosed herein are methods of treating one or more tumors by administering to the subject a therapeutically effective amount of a combination of RAD1901 or solvates (e.g., hydrate) or salts thereof and one or more second therapeutic agent(s) (e.g., everolimus). The cancer is an estrogen-dependent cancer, such as breast cancer, ovarian cancer, colon cancer, endometrial cancer, or prostate cancer.
    Type: Application
    Filed: October 25, 2021
    Publication date: April 14, 2022
    Inventor: Gary HATTERSLEY
  • TRANSDERMAL SYSTEM FOR THE DELIVERY OF ABALOPARATIDE AND METHOD OF USE FOR TREATING OSTEOPOROSIS
    Publication number: 20210379162
    Abstract: Provided herein are methods for treating osteoporosis and increasing bone mass density, that includes administering once a day, for about 5 minutes, a transdermal patch loaded with about 300 ?g of abaloparatide, and ZnCl2 at a molar ratio of 2.2:1 of ZnCl2:abaloparatide. Also provided are the single-use transdermal patches loaded with about 300 ?g of abaloparatide, and ZnCl2 at a molar ratio of 2.2:1 of ZnCl2:abaloparatide.
    Type: Application
    Filed: August 6, 2021
    Publication date: December 9, 2021
    Applicants: Radius Health, Inc., Kindeva Drug Delivery L.P.
    Inventors: Kenneth Brown, Ehab Hamed, Alan Harris, Gary Hattersley, Joan Moseman, Jamal Saeh, Lisa Dick
  • FORMULATIONS OF ABALOPARATIDE, TRANSDERMAL PATCHES THEREOF, AND USES THEREOF
    Publication number: 20210369816
    Abstract: Disclosed are abaloparatide formulations for transdermal delivery of a therapeutically effective amount of abaloparatide, as well as transdermal patches prepared using these formulations, methods of preparing the disclosed formulations and patches, and methods of using these formulations and patches to treat osteoporosis, osteopenia, osteoarthritis, and/or bone fracture, improve bone mineral density (BMD), improve trabecular bone score (TBS), and treat, prevent, and/or reduce bone fractures.
    Type: Application
    Filed: March 23, 2021
    Publication date: December 2, 2021
    Applicants: Radius Health, Inc., Kindeva Drug Delivery L.P.
    Inventors: Gary Hattersley, Alan Harris, Jamal Saeh, Ehab Hamed, Kenneth Brown, Daniel Dohmeier, Joan Moseman, Ying Zhang, Lisa Dick
  • Formulations of abaloparatide, transdermal patches thereof, and uses thereof
    Patent number: 10980862
    Abstract: Disclosed are abaloparatide formulations for transdermal delivery of a therapeutically effective amount of abaloparatide, as well as transdermal patches prepared using these formulations, methods of preparing the disclosed formulations and patches, and methods of using these formulations and patches to treat osteoporosis, osteopenia, osteoarthritis, and/or bone fracture, improve bone mineral density (BMD), improve trabecular bone score (TBS), and treat, prevent, and/or reduce bone fractures.
    Type: Grant
    Filed: January 3, 2020
    Date of Patent: April 20, 2021
    Assignees: Radius Health, Inc., Kindeva Drug Delivery L.P.
    Inventors: Gary Hattersley, Alan Harris, Jamal Saeh, Ehab Hamed, Kenneth Brown, Daniel Dohmeier, Joan Moseman, Ying Zhang, Lisa Dick
  • METHOD OF DRUG DELIVERY FOR PTH, PTHrP AND RELATED PEPTIDES
    Publication number: 20210052705
    Abstract: The present invention provides compositions, devices, methods and processes related to the intradermal delivery of PTHrP and PTHrP analogues, particularly [Glu22,25, Leu23,28,31, Aib29, Lys26,30]hPTHrP(1-34)NH2.
    Type: Application
    Filed: August 31, 2020
    Publication date: February 25, 2021
    Applicants: Radius Health, Inc., Kindeva Drug Delivery L.P.
    Inventors: Gary Hattersley, Kris J. Hansen, Amy S. Determan, Ying Zhang
  • USES OF PTHrP ANALOGUE IN REDUCING FRACTURE RISK
    Publication number: 20200376088
    Abstract: Disclosed herein are PTHrP or analogues thereof, such as abaloparatide, for preventing or reducing bone fractures in subjects in need thereof, as well as methods of using PTHrP or analogues thereof to prevent or reduce bone fractures. Also disclosed are PTHrP or analogues thereof, such as abaloparatide, for increasing BMD and/or TBS in subjects in need thereof, as well as methods of using PTHrP or analogues thereof to increase BMD and/or TBS.
    Type: Application
    Filed: June 16, 2020
    Publication date: December 3, 2020
    Applicant: Radius Health, Inc.
    Inventor: Gary Hattersley