Abstract: The present disclosure provides methods for treating, preventing, or ameliorating one or more symptoms of birch allergy or allergic disease in a subject by administering to the subject an antibody or antigen-binding fragment thereof that binds Bet v 1, or a cocktail of antibodies or antigen-binding fragments thereof that bind Bet v 1.

Abstract: The present invention provides methods for preventing and treating SARS-CoV-2 infections, COVID-19, or symptoms thereof. The methods of the invention feature the administration of one or more antigen-binding molecules (e.g., antibodies) that bind a surface protein of SARS-CoV-2 (e.g., spike protein).

Abstract: The present invention provides methods for treating an allergy by administering one or more antibodies that bind specifically to the allergen. In certain embodiments, the antibodies useful for treating an allergen, bind specifically to the cat allergen, Fel d1. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to Fel d1. The antibodies of the invention are useful for binding to the Fel d1 allergen in vivo, thus preventing binding of the Fel d1 allergen to pre-formed IgE on the surface of mast cells or basophils. In doing so, the antibodies act to prevent the release of histamine and other inflammatory mediators from mast cells and/or basophils, thus ameliorating the untoward response to the cat allergen in sensitized individuals.

Abstract: The present disclosure provides methods for treating, preventing, or ameliorating one or more symptoms of birch allergy or allergic disease in a subject by administering to the subject an antibody or antigen-binding fragment thereof that binds Bet v 1, or a cocktail of antibodies or antigen-binding fragments thereof that bind Bet v 1.

Abstract: In a method a web page hosting a tag script has a first area and a second area smaller than the first area. The first area contains a third area smaller than the first area. The third area is not positioned within the second area when the web page is loaded, and the third area contains a first ad content sourced from a first real-time ad bidding auction. Determining in real time via the tag script (a) whether the first ad content was loaded in the web page for a predefined time period, and (b) based on the other determining whether the third area has been scrolled into the second area as of or after the predefined time period has expired, and requesting a second real-time ad bidding auction for a second ad content to be input into the third area and replace the first ad content.

Abstract: In a method a web page hosting a tag script has a first area and a second area smaller than the first area. The first area contains a third area smaller than the first area. The third area is not positioned within the second area when the web page is loaded, and the third area contains a first ad content sourced from a first real-time ad bidding auction. Determining in real time via the tag script (a) whether the first ad content was loaded in the web page for a predefined time period, and (b) based on the other determining whether the third area has been scrolled into the second area as of or after the predefined time period has expired, and requesting a second real-time ad bidding auction for a second ad content to be input into the third area and replace the first ad content.

Abstract: The present invention relates to compositions and methods for altering body composition in a subject, wherein the alteration of body composition is an increase in muscle mass and a reduction of fat mass simultaneously. The present invention also relates to compositions and methods for reducing fat mass in a subject. The compositions and methods also increase muscle volume and lean body mass in the subject. The present invention also relates to compositions that comprise a GDF8 inhibitor and an Activin A inhibitor and the use of such compositions to treat diseases and disorders characterized by increased fat mass, and/or decreased muscle volume.

Abstract: In a method a web page hosting a tag script has a first area and a second area smaller than the first area. The first area contains a third area smaller than the first area. The third area is not positioned within the second area when the web page is loaded, and the third area contains a first ad content sourced from a first real-time ad bidding auction. Determining in real time via the tag script (a) whether the first ad content was loaded in the web page for a predefined time period, and (b) based on the other determining whether the third area has been scrolled into the second area as of or after the predefined time period has expired, and requesting a second real-time ad bidding auction for a second ad content to be input into the third area and replace the first ad content.

Abstract: The present invention provides methods for treating an allergy by administering one or more antibodies that bind specifically to the allergen. In certain embodiments, the antibodies useful for treating an allergen, bind specifically to the cat allergen, Fel d1. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to Fel d1. The antibodies of the invention are useful for binding to the Fel d1 allergen in vivo, thus preventing binding of the Fel d1 allergen to pre-formed IgE on the surface of mast cells or basophils. In doing so, the antibodies act to prevent the release of histamine and other inflammatory mediators from mast cells and/or basophils, thus ameliorating the untoward response to the cat allergen in sensitized individuals.

Abstract: The present invention relates to compositions and methods for altering body composition in a subject, wherein the alteration of body composition is an increase in muscle mass and a reduction of fat mass simultaneously. The present invention also relates to compositions and methods for reducing fat mass in a subject. The compositions and methods also increase muscle volume and lean body mass in the subject. The present invention also relates to compositions that comprise a GDF8 inhibitor and an Activin A inhibitor and the use of such compositions to treat diseases and disorders characterized by increased fat mass, and/or decreased muscle volume.

Abstract: The present disclosure provides methods for treating, preventing, or ameliorating one or more symptoms of birch allergy or allergic disease in a subject by administering to the subject an antibody or antigen-binding fragment thereof that binds Bet v 1, or a cocktail of antibodies or antigen-binding fragments thereof that bind Bet v 1.

Abstract: The present invention provides methods for preventing and treating SARS-CoV-2 infections, COVID-19, or symptoms thereof. The methods of the invention feature the administration of one or more antigen-binding molecules (e.g., antibodies) that bind a surface protein of SARS-CoV-2 (e.g., spike protein).

Abstract: In a method a web page hosting a tag script has a first area and a second area smaller than the first area. The first area contains a third area smaller than the first area. The third area is not positioned within the second area when the web page is loaded, and the third area contains a first ad content sourced from a first real-time ad bidding auction. Determining in real time via the tag script (a) whether the first ad content was loaded in the web page for a predefined time period, and (b) based on the other determining whether the third area has been scrolled into the second area as of or after the predefined time period has expired, and requesting a second real-time ad bidding auction for a second ad content to be input into the third area and replace the first ad content.

Abstract: Methods for treating fibrodysplasia ossificans progressiva (FOP) in human subjects are provided. Such methods involve administering to a subject having FOP a therapeutically effective amount of an Activin A antagonist, such as an antibody against Activin A.

Abstract: In a method a web page hosting a tag script has a first area and a second area smaller than the first area. The first area contains a third area smaller than the first area. The third area is not positioned within the second area when the web page is loaded, and the third area contains a first ad content sourced from a first real-time ad bidding auction. Determining in real time via the tag script (a) whether the first ad content was loaded in the web page for a predefined time period, and (b) based on the other determining whether the third area has been scrolled into the second area as of or after the predefined time period has expired, and requesting a second real-time ad bidding auction for a second ad content to be input into the third area and replace the first ad content.

Abstract: The present invention relates to compositions and methods for altering body composition in a subject, wherein the alteration of body composition is an increase in muscle mass and a reduction of fat mass simultaneously. The present invention also relates to compositions and methods for reducing fat mass in a subject. The compositions and methods also increase muscle volume and lean body mass in the subject. The present invention also relates to compositions that comprise a GDF8 inhibitor and an Activin A inhibitor and the use of such compositions to treat diseases and disorders characterized by increased fat mass, and/or decreased muscle volume.

Abstract: The invention relates to a shift rail position sensing system. There is a need for a rapid and accurate shift rail position sensing system. In a transmission shift mechanism shifts are performed by axially moving a shift rail which is slidable in a rail bore in a housing. A rail position sensing system includes a groove formed in the shift rail and a Hall effect sensor. The groove includes a curved bottom surface, a first ramp surface extending from one side of the bottom surface to an outer peripheral surface of the shift rail, and a second ramp surface extending from a second side of the bottom surface to an outer peripheral surface of the shift rail. The Hall effect sensor has a sensor shaft with an axis normal to an axis of the shift rail. The sensor shaft has a sensing tip which adjacent to and spaced apart from the groove, so that the Hall effect sensor is sensitive an entire range of positions of the shift rail.

Abstract: The invention relates to a shift rail position sensing system. There is a need for a rapid and accurate shift rail position sensing system. In a transmission shift mechanism shifts are performed by axially moving a shift rail which is slidable in a rail bore in a housing. A rail position sensing system includes a groove formed in the shift rail and a Hall effect sensor. The groove includes a curved bottom surface, a first ramp surface extending from one side of the bottom surface to an outer peripheral surface of the shift rail, and a second ramp surface extending from a second side of the bottom surface to an outer peripheral surface of the shift rail. The Hall effect sensor has a sensor shaft with an axis normal to an axis of the shift rail. The sensor shaft has a sensing tip which adjacent to and spaced apart from the groove, so that the Hall effect sensor is sensitive an entire range of positions of the shift rail.

Abstract: Methods, systems and machine-readable instructions for managing images are described. In one aspect, images are segmented into image clusters. A page layout for a contact sheet comprising thumbnail clusters each comprising thumbnails of the images in respective ones of the image clusters is generated. The page layout divides at least a portion of the contact sheet into regions each containing a respective one of the thumbnail clusters and at least one associated user input field. A description of the page layout is stored on a machine-readable medium.

Abstract: A smart electronic receipt system that provides intelligent receipts, called Smart Receipts, that electronically document a transaction between two parties and maintains a persistent connection between the two parties following a successful online transaction. A Trusted Agent on the Buyer's client system creates an order record which is stored in a database on a Trusted Agent Server and starts the transaction process with the merchant. A Smart Receipt is delivered by a Smart Receipt Agent over a secure connection from the merchant to the Trusted Agent Server upon successful completion of a purchase and reflects the details of the transaction. It is stored in a secure database on the Trusted Agent Server and is made available to the Buyer (user) through a Trusted Agent located on his machine. The Trusted Agent Server compares the order record Limited Edition Digital Objects (LEDOs) stored in database with the Smart Receipt's LEDO to find the corresponding order record.