Patents by Inventor Gary Horvath

Gary Horvath has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Dispersive pipette extraction system for purification of large biomolecules
    Patent number: 11161107
    Abstract: The present invention provides a disposable pipette tip for dispersive solid phase extraction (SPE) that allows for rapid, automatable purification of large biomolecules, such as nucleic acids, proteins and polypeptides without the need for additional tools such as centrifuges, magnetic plates or vacuum manifolds. The pipette tip is designed for optimal biomolecule isolation while maintaining sample integrity. Optimized methods of using the dispersive pipette extraction system for isolation of large biomolecules are also provided.
    Type: Grant
    Filed: May 25, 2017
    Date of Patent: November 2, 2021
    Assignee: INTEGRATED MICRO-CHROMATOGRAPHY SYSTEMS, INC.
    Inventors: Brian Todd Mullis, Gary Horvath, Lim Andrew Lee, Sunil Hwang, William Edward Brewer
  • Mutant lactobacillus beta-glucuronidase enzymes with enhanced enzymatic activity
    Patent number: 9909111
    Abstract: Mutated Lactobacillus brevis strain 269Y ?-glucuronidase enzymes with enhanced enzymatic activity at low pH (e.g., below pH 6.8), as well as enhanced thermostability as compared to wild type enzyme are provided. The enzymes of the invention advantageously allow for accurate analysis of bodily samples for the presence of drugs at low pH and in 30 minutes or less, as compared to the several hours needed using prior enzyme preparations. Methods of using the mutated enzymes for hydrolysis of glucuronide substrates, including opiates and benzodiazepines, are also provided.
    Type: Grant
    Filed: March 21, 2016
    Date of Patent: March 6, 2018
    Assignee: INTEGRATED MICRO-CHROMATOGRAPHY SYSTEMS
    Inventors: Jia Yang, Gary Horvath, Pongkwan Sitasuwan, Margarita Marinova, Qian Wang, Lim Andrew Lee
  • DISPERSIVE PIPETTE EXTRACTION SYSTEM FOR PURIFICATION OF LARGE BIOMOLECULES
    Publication number: 20170354966
    Abstract: The present invention provides a disposable pipette tip for dispersive solid phase extraction (SPE) that allows for rapid, automatable purification of large biomolecules, such as nucleic acids, proteins and polypeptides without the need for additional tools such as centrifuges, magnetic plates or vacuum manifolds. The pipette tip is designed for optimal biomolecule isolation while maintaining sample integrity. Optimized methods of using the dispersive pipette extraction system for isolation of large biomolecules are also provided.
    Type: Application
    Filed: May 25, 2017
    Publication date: December 14, 2017
    Inventors: Brian Todd MULLIS, Gary Horvath, Lim Andrew Lee, Sunil Hwang, William Edward Brewer
  • MUTANT LACTOBACILLUS BETA-GLUCURONIDASE ENZYMES WITH ENHANCED ENZYMATIC ACTIVITY
    Publication number: 20170267985
    Abstract: Mutated Lactobacillus brevis strain 269Y ?-glucuronidase enzymes with enhanced enzymatic activity at low pH (e.g., below pH 6.8), as well as enhanced thermostability as compared to wild type enzyme are provided. The enzymes of the invention advantageously allow for accurate analysis of bodily samples for the presence of drugs at low pH and in 30 minutes or less, as compared to the several hours needed using prior enzyme preparations. Methods of using the mutated enzymes for hydrolysis of glucuronide substrates, including opiates and benzodiazepines, are also provided.
    Type: Application
    Filed: March 21, 2016
    Publication date: September 21, 2017
    Inventors: Jia YANG, Gary Horvath, Pongkwan Sitasuwan, Margarita Marinova, Qian Wang, Lim Andrew Lee