Patents by Inventor Gary I. Yellen

Gary I. Yellen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmacological modulators of voltage-gated potassium ion channels
    Patent number: 6291442
    Abstract: Disclosed herein is the discovery that an allosteric receptor site exists on the intracellular surface of Shaker class voltage-gated potassium ion channels that is distinct from the pore and is involved in regulating gating of the pore. A class of compounds has been identified that binds to this allosteric site and modulates the length of time the channel remains open. Based on these discoveries, novel methods of modulating the activity of Shaker class voltage-gated potassium ion channels and assays for determining which compounds are modulators of these ion channels are reported herein.
    Type: Grant
    Filed: February 2, 1999
    Date of Patent: September 18, 2001
    Assignee: The General Hospital Corporation
    Inventor: Gary I. Yellen