Patents by Inventor Gary J. Brenner

Gary J. Brenner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TREATMENT OF BENIGN NERVOUS SYSTEM TUMORS USING ATTENUATED SALMONELLA TYPHIMURIUM
    Publication number: 20220125906
    Abstract: Compositions and methods for the treatment of benign nervous system tumors including schwannomas using attenuated Salmonella typhimurium and optionally one or more checkpoint inhibitors.
    Type: Application
    Filed: February 27, 2020
    Publication date: April 28, 2022
    Inventors: Gary J. Brenner, Sherif Ahmed
  • METHODS AND COMPOSITIONS RELATING THE TREATMENT OF TUMORS
    Publication number: 20190336577
    Abstract: Described herein are methods and compositions relating to the treatment of a tumor (e.g., schwannoma) by increasing expression of Apoptosis-associated Speck-like protein containing a CARD (ASC) and/or gasdermin D. In some embodiment, the increased expression is provided by means of a vector or construct comprising a nucleic acid encoding Apoptosis-associated Speck-like protein containing a CARD (ASC) and/or gasdermin D operably linked to a Schwann-lineage cell-specific promoter. In some embodiments, the vector is a viral vector.
    Type: Application
    Filed: December 6, 2017
    Publication date: November 7, 2019
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Gary J. BRENNER, Giulia FULCI, Sherif AHMED
  • AAV1-caspase gene therapy induced pyroptosis for the treatment of tumors
    Patent number: 9644215
    Abstract: Described herein are compositions and methods for treating, inhibiting, preventing, reducing the severity of and/or reducing the progression of schwannoma, as well as any disease or physiological disease-state in which schwannoma plays a role. The compositions comprise an rAAV vector that includes a caspase-1 gene or a variant thereof and a Schwann cell specific promoter.
    Type: Grant
    Filed: January 30, 2014
    Date of Patent: May 9, 2017
    Assignee: The General Hospital Corporation
    Inventors: Gary J. Brenner, Xandra O. Breakefield, Giulia Fulci
  • GENE THERAPY INDUCED PYROPTOSIS FOR THE TREATMENT OF TUMORS
    Publication number: 20140309288
    Abstract: Described herein are compositions and methods for treating, inhibiting, preventing, reducing the severity of and/or reducing the progression of schwannoma, as well as any disease or physiological disease-state in which schwannoma plays a role. The compositions comprise an rAAV vector that includes a caspase-1 gene or a variant thereof and a Schwann cell specific promoter.
    Type: Application
    Filed: January 30, 2014
    Publication date: October 16, 2014
    Applicant: THE GENERAL HOSPITAL CORPORATION
    Inventors: Gary J. Brenner, Xandra O. Breakefield, Giulia Fulci