Patents by Inventor Gary J. Bridger

Gary J. Bridger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS WITH ENHANCED EFFICACY
    Publication number: 20220409589
    Abstract: The invention relates to heterocyclic compounds consisting of a core nitrogen atom surrounded by three pendant groups, wherein two of the three pendant groups are preferably benzimidazolyl methyl and tetrahydroquinolyl, and the third pendant group contains N and optionally contains additional rings. The compounds bind to chemokine receptors, including CXCR4 and CCR5, and demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
    Type: Application
    Filed: January 13, 2022
    Publication date: December 29, 2022
    Inventors: Gary J. Bridger, Renato T. Skerlj, Al Kaller, Curtis Harwig, David Bogucki, Trevor R. Wilson, Jason B. Crawford, Ernest J. McEachern, Bem Atsma, Siqiao Nan, Yuanxi Zhou, Dominique Schols, Christopher Dennis Smith, Maria Rosaria Di Fluri
  • USE OF CXCR4 ANTAGONISTS
    Publication number: 20210161859
    Abstract: Presently disclosed are methods and compositions for treating or preventing WHIM syndrome and certain other disorders or conditions with a certain CXCR4 antagonist.
    Type: Application
    Filed: July 13, 2020
    Publication date: June 3, 2021
    Inventors: David C. DALE, Gary J. BRIDGER, Frank J. HSU
  • CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS WITH ENHANCED EFFICACY
    Publication number: 20200000774
    Abstract: The invention relates to heterocyclic compounds consisting of a core nitrogen atom surrounded by three pendant groups, wherein two of the three pendant groups are preferably benzimidazolyl methyl and tetrahydroquinolyl, and the third pendant group contains N and optionally contains additional rings. The compounds bind to chemokine receptors, including CXCR4 and CCR5, and demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
    Type: Application
    Filed: April 10, 2019
    Publication date: January 2, 2020
    Inventors: Gary J. Bridger, Renato T. Skerlj, Al Kaller, Curtis Harwig, David Bogucki, Trevor R. Wilson, Jason B. Crawford, Ernest J. McEachern, Bem Atsma, Siqiao Nan, Yuanxi Zhou, Dominique Schols, Christopher Dennis Smith, Maria Rosaria Di Fluri
  • METHODS TO MOBILIZE PROGENITOR/STEM CELLS
    Publication number: 20190216773
    Abstract: Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed.
    Type: Application
    Filed: August 21, 2018
    Publication date: July 18, 2019
    Inventors: Gary J. BRIDGER, Michael J. ABRAMS, Geoffrey W. HENSON, Ronald Trevor MACFARLAND, Gary B. CALANDRA, Hal E. BROXMEYER, David C. DALE
  • Chemokine receptor binding heterocyclic compounds with enhanced efficacy
    Patent number: 10322111
    Abstract: The invention relates to heterocyclic compounds consisting of a core nitrogen atom surrounded by three pendant groups, wherein two of the three pendant groups are preferably benzimidazolyl methyl and tetrahydroquinolyl, and the third pendant group contains N and optionally contains additional rings. The compounds bind to chemokine receptors, including CXCR4 and CCR5, and demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
    Type: Grant
    Filed: February 8, 2016
    Date of Patent: June 18, 2019
    Assignee: GENZYME CORPORATION
    Inventors: Gary J. Bridger, Renato T. Skerlj, Al Kaller, Curtis Harwig, David Earl Bogucki, Trevor R. Wilson, Jason B. Crawford, Ernest J. McEachern, Bem Atsma, Siqiao Nan, Yuanxi Zhou, Dominique Schols, Christopher Dennis Smith, Maria Rosario DiFluri
  • METHODS TO MOBILIZE PROGENITOR/STEM CELLS
    Publication number: 20170049747
    Abstract: Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed.
    Type: Application
    Filed: March 18, 2016
    Publication date: February 23, 2017
    Inventors: Gary J. BRIDGER, Michael J. ABRAMS, Geoffrey W. HENSON, Ronald Trevor MACFARLAND, Gary B. CALANDRA, Hal E. BROXMEYER, David C. DALE
  • CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS WITH ENHANCED EFFICACY
    Publication number: 20160228413
    Abstract: The invention relates to heterocyclic compounds consisting of a core nitrogen atom surrounded by three pendant groups, wherein two of the three pendant groups are preferably benzimidazolyl methyl and tetrahydroquinolyl, and the third pendant group contains N and optionally contains additional rings. The compounds bind to chemokine receptors, including CXCR4 and CCR5, and demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
    Type: Application
    Filed: February 8, 2016
    Publication date: August 11, 2016
    Inventors: Gary J. BRIDGER, Renato T. SKERLJ, Al KALLER, Curtis HARWIG, David Earl BOGUCKI, Trevor R. WILSON, Jason B. CRAWFORD, Ernest J. MCEACHERN, Bem ATSMA, Siqiao NAN, Yuanxi ZHOU, Dominique SCHOLS, Christopher Dennis SMITH, Maria Rosario DIFLURI
  • METHODS TO MOBILIZE PROGENITOR/STEM CELLS
    Publication number: 20150246019
    Abstract: Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed.
    Type: Application
    Filed: October 3, 2014
    Publication date: September 3, 2015
    Inventors: Gary J. BRIDGER, Michael J. Abrams, Geoffrey W. Henson, Ronald Trevor Macfarland, Gary B. Calandra, Hal E. Broxmeyer, David C. Dale
  • Chemokine Receptor Binding Heterocyclic Compounds With Enhanced Efficacy
    Publication number: 20150038509
    Abstract: The invention relates to heterocyclic compounds consisting of a core nitrogen atom surrounded by three pendant groups, wherein two of the three pendant groups are preferably benzimidazolyl methyl and tetrahydroquinolyl, and the third pendant group contains N and optionally contains additional rings. The compounds bind to chemokine receptors, including CXCR4 and CCR5, and demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).
    Type: Application
    Filed: June 12, 2014
    Publication date: February 5, 2015
    Inventors: Gary J. Bridger, Renato T. Skerlj, Al Kaller, Curtis Harwig, David Earl Bogucki, Trevor R. Wilson, Jason B. Crawford, Ernest J. McEachern, Bem Atsma, Siqiao Nan, Yuanxi Zhou, Dominique Schols, Christopher Dennis Smith, Maria Rosario DiFluri
  • Use of CXCR4 Antagonists
    Publication number: 20150030561
    Abstract: Presently disclosed are methods and compositions for treating or preventing WHIM syndrome and certain other disorders or conditions with a certain CXCR4 antagonist.
    Type: Application
    Filed: May 15, 2012
    Publication date: January 29, 2015
    Applicants: GENZYME CORP., UNIVERSITY OF WASHINGTON CENTER FOR COMMERCIALIZATION
    Inventors: David C. Dale, Gary J. Bridger, Frank J. Hsu
  • Methods For Increasing Blood Flow And/Or Promoting Tissue Regeneration
    Publication number: 20130095076
    Abstract: Methods for increasing blood flow and/or regenerating tissue using compounds which bind to the chemokine receptor CXCR4 are disclosed. Preferred embodiments of such compounds are of the formula Z-linker-Z???(1).
    Type: Application
    Filed: July 5, 2012
    Publication date: April 18, 2013
    Applicant: Genzyme Corporation
    Inventors: Gary J. BRIDGER, Simon P. FRICKER
  • METHODS TO MOBILIZE PROGENITOR/STEM CELLS
    Publication number: 20110129448
    Abstract: Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed.
    Type: Application
    Filed: February 8, 2011
    Publication date: June 2, 2011
    Applicant: Genzyme Corporation
    Inventors: Gary J. BRIDGER, Michael J. Abrams, Geoffrey W. Henson, Ronald Trevor MacFarland, Gary B. Calandra, Hal E. Broxmeyer, David C. Dale
  • Methods to mobilize progenitor/stem cells
    Patent number: 7935692
    Abstract: Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed.
    Type: Grant
    Filed: November 8, 2005
    Date of Patent: May 3, 2011
    Assignee: Genzyme Corporation
    Inventors: Gary J. Bridger, Michael J. Abrams, Geoffrey W. Henson, Ronald Trevor MacFarland, Gary B. Calandra, Hal E. Broxmeyer, David C. Dale
  • Methods to mobilize progenitor/stem cells
    Patent number: 7897590
    Abstract: Methods to elevate progenitor and stem cell counts in animal subjects using compounds which bind to the chemokine receptor CXCR4 are disclosed.
    Type: Grant
    Filed: August 20, 2007
    Date of Patent: March 1, 2011
    Assignee: Genzyme Corporation
    Inventors: Gary J. Bridger, Michael J. Abrams, Geoffrey W. Henson, Ronald Trevor MacFarland, Gary B. Calandra, Hal E. Broxmeyer, David C. Dale
  • CXCR4 chemokine receptor binding compounds
    Patent number: 7863293
    Abstract: The present invention relates to compounds that bind to chemokine receptors, and having the formula wherein each A, X, Y, R1, R2 and R3 are substituents. The present invention also relates to methods of using such compounds, such as in treating HIV infection and inflammatory conditions such as rheumatoid arthritis. Furthermore, the present invention relates to methods to elevate progenitor and stem cell counts, as well as methods to elevate white blood cell counts, using such compounds.
    Type: Grant
    Filed: November 6, 2007
    Date of Patent: January 4, 2011
    Assignee: Genzyme Corporation
    Inventors: Gary J. Bridger, Ernest J. McEachern, Renato Skerlj, Dominique Schols, Ian Baird, Al Kaller, Curtis Harwig, Yongbao Zhu, Gang Chen, Krystyna Skupinska
  • Combination Therapy
    Publication number: 20100178271
    Abstract: Methods to mobilize progenitor and/or stem cells from the bone marrow to the bloodstream by administering a combination of at least one CXCR4 inhibitor, at least one CXCR2 agonist, and G-CSF are described. The combinations may also be used to increase the effectiveness of chemotherapy and radiation therapies for hematopoietic malignancies.
    Type: Application
    Filed: August 7, 2007
    Publication date: July 15, 2010
    Applicant: GENZYME CORPORATION
    Inventors: Gary J. Bridger, Louis M. Pelus
  • CXCR4 antagonists
    Patent number: 7709486
    Abstract: The present invention is drawn to novel antiviral compounds, pharmaceutical compositions and their use. More specifically this invention is drawn to derivatives of monocyclic polyamines which have activity in standard tests against HIV- or FIV-infected cells as well as other biological activity related to binding of ligands to chemokine receptors that mediate a number of mammalian embryonic developmental processes.
    Type: Grant
    Filed: July 29, 2008
    Date of Patent: May 4, 2010
    Assignee: Genzyme Corporation
    Inventors: Gary J. Bridger, Eva Maria Boehringer, Zhongren Wang, Dominique Schols, Renato Tony Skerlj, David Earl Bogucki
  • CHEMOKINE RECEPTOR BINDING HETEROCYCLIC COMPOUNDS
    Publication number: 20100105915
    Abstract: Heterocyclic compounds that bind chemokine receptors and inhibit the binding of their natural ligands are disclosed. The invention compounds are protective against infection by HIV and exert effects characteristic of antagonists to the CXCR4 receptor.
    Type: Application
    Filed: November 4, 2009
    Publication date: April 29, 2010
    Inventors: Gary J. BRIDGER, Renato Skerlj, Ai Kaller, Curtis Harwig, David Bogucki, Trevor R. Wilson, Jason Crawford, Ernest J. Mceachern, Bem Atsma, Siqiao Nan, Yuanxi Zhou, Dominique Schols
  • METHODS FOR INCREASING BLOOD FLOW AND/OR PROMOTING TISSUE REGENERATION
    Publication number: 20100035941
    Abstract: Methods for increasing blood flow and/or regenerating tissue using compounds which bind to the chemokine receptor CXCR4 are disclosed.
    Type: Application
    Filed: February 24, 2006
    Publication date: February 11, 2010
    Inventors: Gary J. Bridger, Simon P. Fricker
  • Aromatic-linked polyamine macrocyclic compounds with anti-HIV activity
    Patent number: RE42152
    Abstract: Polyamine macrocyclic compounds, e.g. of 10 to 15 ring members and 3 to 6 ring amine nitrogens, linked through methylene groups to an aromatic moiety, show high selective activity against HIV.
    Type: Grant
    Filed: December 16, 1992
    Date of Patent: February 15, 2011
    Assignee: Genzyme Corporation
    Inventors: Gary J. Bridger, Sreenivasan Padmanbhan, Renato Skerlj, David M. Thornton