Abstract: A medical device system may include an elongate shaft having a lumen extending from a proximal end of the elongate shaft to a distal end of the elongate shaft, a medical device disposed proximate the distal end of the elongate shaft, a release wire disposed within the lumen of the elongate shaft, wherein the release wire releasably secures the medical device to the distal end of the elongate shaft, a securement member fixedly attached to the proximal end of the elongate shaft and to a proximal end of the release wire, and a microcatheter configured to deliver the medical device to a treatment site, the elongate shaft and the medical device being slidably disposed within a lumen of the microcatheter. A proximal portion of the securement member may be configured to disengage from a distal portion of the securement member.

Abstract: A movable protection and/or rewrapping device for a balloon catheter may include a tubular member with a bore extending along a length thereof. The tubular member may have at least one rib disposed on an inner surface of the bore. The tubular member may be flared away from the bore at one end and inwardly tapered at the other end. The rewrapping device may include an actuator configured to open a longitudinal slit in the tubular member.

Abstract: An embolic coil delivery assembly is disclosed. The delivery system may include a tubular member having a distal portion, a proximal portion and a lumen extending therein. The system may further include a tip member secured to the tubular member. The tip member may include a distal portion and a bonding portion. The bonding portion may include a bonding surface. The system may also include an embolic coil releasably disposed within the distal portion of the tip member. The distal portion of the tubular member may extend over the bonding portion of the tip member. The bonding surface may be configured to mechanically interlock with the tubular member.

Abstract: The disclosure describes stent delivery systems and its related methods of use. A stent delivery system including an inner shaft with a stent disposed about the distal region, a deployment sheath slidably disposed about the inner shaft, a handle coupled to the deployment sheath, and an intermediate shaft disposed about the inner shaft, positioned proximally of the stent. Further, proximal portion of the intermediate shaft is disposed within the handle and includes a support member.

Abstract: A medical device for renal denervation may include a catheter shaft including an outer shaft having a lumen formed therein and an inner shaft extending within the lumen of the outer shaft. The catheter may further include an expandable member having a proximal region coupled to a distal region of the outer shaft, and a distal region of the expandable member may be coupled to a distal region of the inner shaft. In some embodiments, one or more active electrodes may be disposed on an exterior surface of the expandable member and capable of providing the renal denervation treatment. In some embodiments, the inner shaft may be rotatable in relation to the outer shaft and/or the outer shaft may be rotatable in relation to the inner shaft.

Abstract: A medical device system may include an elongate shaft having a lumen extending from a proximal end of the elongate shaft to a distal end of the elongate shaft, a medical device disposed proximate the distal end of the elongate shaft, a release wire disposed within the lumen of the elongate shaft, wherein the release wire releasably secures the medical device to the distal end of the elongate shaft, a securement member fixedly attached to the proximal end of the elongate shaft and to a proximal end of the release wire, and a microcatheter configured to deliver the medical device to a treatment site, the elongate shaft and the medical device being slidably disposed within a lumen of the microcatheter. A proximal portion of the securement member may be configured to disengage from a distal portion of the securement member.

Abstract: Medical devices and methods for making and using the same are disclosed. An example medical device may include a medical device for renal nerve ablation. The medical device may include an elongate shaft having a distal region. An expandable member may be coupled to the distal region. A plurality of electrodes may be coupled to the expandable member and a single conductive member may be coupled to each electrode. Where one of the plurality of electrodes is active, the remaining electrodes may be inactive and act as ground or return electrodes. The electrode of the plurality of electrodes that is active may change over time.

Abstract: A system for treating tissue includes a first fastener including a first anchoring element at a distal end thereof for anchoring the first fastener in a first target portion of tissue extending about a periphery of a tissue defect to be treated and a first suture extending from a proximal end thereof. The system also includes a second fastener including a second anchoring element at a distal end thereof for anchoring the second fastener in a second target portion of tissue extending about a periphery of a tissue defect to be treated and a second suture extending from a proximal end thereof. Furthermore, the system includes a cinch element disposed about both of the first and second sutures and slidable therealong such that a tension applied to the first and second sutures draws the first and second fasteners toward one another to close the tissue defect.

Abstract: A handle for delivering a medical device comprises a housing having therein a wheel, a rack, and a catheter member. The wheel comprises a pinion gear that selectively engages gear teeth on the rack. The rack is selectively engaged and disengaged from the pinion gear in order to reduce the force necessary to manually pull the rack.

Abstract: An embolic coil delivery assembly is disclosed. The delivery system may include a tubular member having a distal portion, a proximal portion and a lumen extending therein. The system may further include a tip member secured to the tubular member. The tip member may include a distal portion and a bonding portion. The bonding portion may include a bonding surface. The system may also include an embolic coil releasably disposed within the distal portion of the tip member. The distal portion of the tubular member may extend over the bonding portion of the tip member. The bonding surface may be configured to mechanically interlock with the tubular member.

Abstract: A movable protection and/or rewrapping device for a balloon catheter may include a tubular member with a bore extending along a length thereof. The tubular member may have at least one rib disposed on an inner surface of the bore. The tubular member may be flared away from the bore at one end and inwardly tapered at the other end. The rewrapping device may include an actuator configured to open a longitudinal slit in the tubular member.

Abstract: Medical devices and methods for making and using the same are disclosed. An example medical device may include a medical device for renal nerve ablation. The medical device may include an elongate shaft having a distal region. An expandable member may be coupled to the distal region. A plurality of electrodes may be coupled to the expandable member and a single conductive member may be coupled to each electrode. Where one of the plurality of electrodes is active, the remaining electrodes may be inactive and act as ground or return electrodes. The electrode of the plurality of electrodes that is active may change over time.

Abstract: A balloon for renal nerve modulation, the balloon comprising a polymer material forming a balloon wall having an interior surface and an exterior surface and flexible circuits adhesively bonded to the exterior surface of the balloon wall, wherein the exterior surface comprises laser induced microstructures on at least a portion of said exterior surface.

Abstract: A medical device for renal denervation may include a catheter shaft including an outer shaft having a lumen formed therein and an inner shaft extending within the lumen of the outer shaft. The catheter may further include an expandable member having a proximal region coupled to a distal region of the outer shaft, and a distal region of the expandable member may be coupled to a distal region of the inner shaft. In some embodiments, one or more active electrodes may be disposed on an exterior surface of the expandable member and capable of providing the renal denervation treatment. In some embodiments, the inner shaft may be rotatable in relation to the outer shaft and/or the outer shaft may be rotatable in relation to the inner shaft.

Abstract: A handle for delivering a medical device comprises a housing having therein a wheel, a rack, and a catheter member. The wheel comprises a pinion gear that selectively engages gear teeth on the rack. The rack is selectively engaged and disengaged from the pinion gear in order to reduce the force necessary to manually pull the rack.

Abstract: A balloon catheter may comprise a primary inflation balloon and a secondary inflation balloon located to one side of the primary inflation balloon. The secondary balloon comprises a first portion and a second portion, the first portion located closer to the primary balloon. The second portion has a greater size than the first portion, and a portion of the second portion extends outwardly beyond the first portion and overhangs the first portion. In some embodiments, a cross-sectional shape of the secondary balloon in an inflated state comprises a mushroom shape.

Abstract: An illustrative balloon catheter is disclosed. The balloon catheter may include an elongate shaft including a proximal section, a midshaft section, and a distal section. In some embodiments, the midshaft section may include a braid encapsulated in a polymer material. Additionally or alternatively, the midshaft section may include a thermoset polymer material. Additionally, in some cases, the distal section may include a distal outer tubular member and a distal inner tubular member, one or more of which may include a polymer material and, in some cases, a braid. Additionally, some example proximal section may include a metal polymer composite material.

Abstract: Improved stent securement in a balloon catheter including balloon modification. The improvement comprises a circumferential fold in at least one of the distal cone portion and proximal cone portion over a portion of the body portion. The fold includes first and second layers of balloon material which are touching each other in a plurality of locations. The fold encompasses a circumferential end portion of the stent for securing it in place until dilation of the balloon.

Abstract: A stent-carrying balloon catheter in which a balloon is positioned within a stent for expanding the stent upon dilation of the balloon. The balloon includes a circumferential fold over a portion of the balloon itself, the fold encompassing a circumferential end portion of the stent for securing it in place until dilation of the balloon.