Abstract: Disclosed herein are cyclic peptides having activity as cell penetrating peptides (CPPs). Disclosed are cyclic cell penetrating peptides (cCPPs) comprising one or more of the cell penetrating peptides disclosed herein. Disclosed are cCPPs comprising a 6-aminohexanoic-spaced oligoarginine. Disclosed are cCPPs comprising the amino acid sequence of CRXRRXRRXRRXRC (SEQ ID NO:1), wherein X is aminohexanoic acid. In some aspects, the cCPP comprises a disulfide bridge. Disclosed are cCPPs comprising the amino acid sequence of RXRRXRRXRRXRC (SEQ ID NO:2), wherein X is aminohexanoic acid. In some aspects, the cCPPs comprise a thioether bridge.

Abstract: There is provided a composition for anti-cancer or anti-inflammatory treatment having an effective amount of N-terminally truncated galectin-3 or its homologues, antibodies to galectin-3 carbohydrate binding sites, or a nucleic acid sequences encoding N-terminally truncated galectin-3 or its homologues, in a pharmaceutically acceptable carrier. Also provided by the present invention is a method of treating disease by administering to a patient in need of such treatment an effective amount of N-terminally truncated galectin-3, its homologues, antibody to galectin-3 carbohydrate binding sites, or a nucleic acid sequence encoding N-terminally truncated galectin-3 in a pharmaceutically acceptable carrier.

Abstract: A blood pressure cuff having a pair of flexible gas-impermeable sheets wherein each of the sheets has an inner and an outer side and wherein the inner sides are placed in contact and the edges of the sheets are fused along a periphery thereof to form an interior chamber. At least one hook fastener portion is disposed on one outer side of one of the sheets and at least one loop portion is disposed on an outer side of the other of the sheets. A conduit means is attached to one of the flexible sheets for connecting to a source of pressurized fluid for allowing inflation and deflation of the interior chamber. The sheets are fused together by RF welding along a perimeter of one outer side of one of the sheets. The hook fastener portion, the loop portion, and the conduit means are each RF welded to an outer side of one of said sheets.