Abstract: Methods for modulating dissolution, bioavailability, bioequivalence and drug delivery profile of thin film drug delivery systems, controlled-release thin film dosage formats, and methods for their manufacture and use are disclosed.

Abstract: A thixotropic formulation includes a high molecular weight, thixotropic, gel-forming, naturally occurring polysaccharide extracted from algae and comprised of repeating sulfated and non-sulfated galactose and 3,6 anhydrogalactose (3,6-AG) units, and includes water.

Abstract: A thixotropic anti-viral formulation includes a high molecular weight, thixotropic, gel-forming, naturally occurring polysaccharide extracted from algae and comprised of repeating sulfated and non-sulfated galactose and 3,6 anhydrogalactose (3,6-AG) units, and includes water.

Abstract: In one embodiment of the present invention a composition is provided comprising a film layer wherein the film layer rapidly dissolves in an oral cavity and a coating comprising a powder matrix, wherein the coating is applied to at least one side of the film layer and wherein the powder matrix comprises a nutritional supplement, an adhesive, a bulking agent, a flow agent, and a sweetener.

Abstract: A thixotropic personal lubricant includes a high molecular weight, thixotropic, gel-forming, naturally occurring polysaccharide extracted from algae and comprised of repeating sulfated and non-sulfated galactose and 3,6 anhydrogalactose (3,6-AG) units, and includes water.

Abstract: An IV holder for securing an IV needle and Luer fitting assembly. The IV holder includes a frame defining an aperture with a first portion and a second portion, the first portion of the aperture further being covered by a transparent window for protecting and securing the IV needle insertion site. The second portion of the aperture is disposed to fit a cylindrical Luer fitting. The holder is adhesively applied to a patient's skin and situated so that the needle insertion site is under the window and the first portion of the aperture while the Luer fitting is disposed within the second portion of the aperture.

Abstract: Methods for modulating dissolution, bioavailability, bioequivalence and drug delivery profile of thin film drug delivery systems, controlled-release thin film dosage formats, and methods for their manufacture and use are disclosed.

Abstract: A thixotropic personal lubricant includes a high molecular weight, thixotropic, gel-forming, naturally occurring polysaccharide extracted from algae and comprised of repeating sulfated and non-sulfated galactose and 3,6 anhydrogalactose (3,6-AG) units, and includes water.

Abstract: Multi-veined chewing gum is produced by injecting a plurality of different liquid flavor/dye compositions into a substantially homogeneous gum base composition or into a laminated or coextruded gum composition. The injection may be performed while the gum composition is being conveyed in one or more extruder head barrels, the injection being at a plurality of radial and/or circumferential positions in the barrel. In embodiments of the invention substantially straight longitudinal veins of color are then partially mixed to partially displace the colored veins in a direction transverse to the direction of extrusion so as to create veined, multi-colored patterns substantially throughout a cross section of the product in a manner so that the multi-colored patterns in the cross-section differ along the length of the extrudate. The extrudate is cut to obtain gum pieces having different veins of injected liquid additives which provide a swirled or marbleized pattern in the opposing cut ends.

Abstract: Multi-veined chewing gum is produced by injecting a plurality of different liquid flavor/dye compositions into a substantially homogeneous gum base composition or into a laminated or coextruded gum composition. The injection may be performed while the gum composition is being conveyed in one or more extruder head barrels, the injection being at a plurality of radial and/or circumferential positions in the barrel. In embodiments of the invention substantially straight longitudinal veins of color are then partially mixed to partially displace the colored veins in a direction transverse to the direction of extrusion so as to create veined, multi-colored patterns substantially throughout a cross section of the product in a manner so that the multi-colored patterns in the cross-section differ along the length of the extrudate. The extrudate is cut to obtain gum pieces having different veins of injected liquid additives which provide a swirled or marbleized pattern in the opposing cut ends.

Abstract: Material such as chewing gum is treated to reduce its density by working it and feeding it through a twin-screw corotating extruder configured to provide flow at first and second longitudinal rates, pulling in a plane normal to the axis of flow, and further working and homogenization.

Abstract: A reduced calorie chewing gum is provided which does not decrease in viscosity upon chewing and contains less than 65% water-solubles, such as sugars and/or sugar alcohols such as sweeteners, and includes gum base containing high levels of inert fillers, such as calcium carbonate or talc in amounts of at least about 40% by weight, softeners, such as lecithin, and optionally synthetic non-caloric sweeteners, such as aspartame, saccharin, or cyclamates. The chewing gum includes at least about 10% air voids entrapped in the gum base matrix which, upon chewing, become filled with moisture causing a dramatic increase in cud volume.

Abstract: A chewing gum is provided which contains gum base and a non-aqueous solid fatty or gelatinous sweetener or flavorant, such as butter, marshmallow or caramel, solubilized in the gum base. The subject chewing gum has the appearance and mouth feel of chewing gum as opposed to candy and a delayed but prolonged sweetness or flavor impact. The chewing gum is laminated with a slab of chewing gum which will supply initial sweetness or flavor impact.A method for producing the above chewing gum is also provided.

Abstract: A tobacco-flavored chewing gum is provided which does not decrease in viscosity upon chewing inasmuch as it is preferably essentially free of water-solubles, and includes gum base containing high levels of inert fillers, such as calcium carbonate or talc in amounts of at least about 50% by weight, softeners, such as lecithin, synthetic non-caloric sweeteners, such as aspartame, saccharin or cyclamates, and tobacco flavors and/or natural tobacco. The chewing gum includes at least about 10% air voids entrapped in the gum base matrix which, upon chewing, become filled with moisture causing a dramatic increase in cud volume.

Abstract: A chewable chewing gum base is provided which is substantially calorie-free, does not decrease in viscosity upon chewing inasmuch as it is essentially free of water-solubles, and includes gum base containing high levels of inert fillers, such as calcium carbonate or talc in amounts of at least about 50% by weight, softeners, such as lecithin, synthetic non-caloric sweeteners, such as aspartame or cyclamates, and flavors. The chewable gum base includes at least about 10% air voids entrapped in the gum base matrix which, upon chewing, become filled with moisture causing a dramatic increase in cud volume.