Patents by Inventor Gary Keith Smith

Gary Keith Smith has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Benzimidazol-1-YL-thiophene compounds for the treatment of cancer
    Publication number: 20080269298
    Abstract: The present invention provides compounds of formula (I): pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
    Type: Application
    Filed: May 1, 2008
    Publication date: October 30, 2008
    Inventors: Clarence W. Andrews, Mui Cheung, Ronda G. Davis-Ward, David Harold Drewry, Kyle Allen Emmitte, Robert Dale Hubbard, Kevin W. Kuntz, James Andrew Linn, Robert Anthony Mook, Gary Keith Smith, James Marvin Veal
  • Bunyaviridal reaper proteins and uses therefore
    Patent number: 7094529
    Abstract: Viral proteins with sequence and functional similarity to the drosophila cell death protein known as Reaper are provided. Reaper plays an important role in the apoptotic pathway. Methods using the viral proteins and nucleotides encoding such proteins are described.
    Type: Grant
    Filed: February 16, 2001
    Date of Patent: August 22, 2006
    Assignee: SmithKline Beecham Corporation
    Inventor: Gary Keith Smith
  • Combination of benzoquinazoline antifolates and protecting agents
    Patent number: 6855712
    Abstract: The use of a protecting agent, for example a folate derivative such as folic acid or leucovorin, in combination with a non-competitive folic acid analogue, for example benzoquinazoline derivatives, for use in reducing the side effects associated with the administration of such non-competitive folic acid analogues, and pharmaceutical formulations comprising such combinations are disclosed.
    Type: Grant
    Filed: May 7, 2003
    Date of Patent: February 15, 2005
    Assignee: SmithKline Beecham Corporation
    Inventors: Gary Keith Smith, David Stanley Duch, Robert Ferone, Arthur Koch
  • Novel combination of benzoquinazoline antifolates and protecting agents
    Publication number: 20030203924
    Abstract: The use of a protecting agent, for example a folate derivative such as folic acid or leucovorin, in combination with a non-competitive folic acid analogue, for example benzoquinazoline derivatives, for use in reducing the side effects associated with the administration of such non-competitive folic acid analogues, and pharmaceutical formulations comprising such combinations are disclosed.
    Type: Application
    Filed: May 7, 2003
    Publication date: October 30, 2003
    Inventors: Gary Keith Smith, David Stanley Duch, Robert Ferone, Arthur Koch
  • Combination of benzoquinazoline antifolates and protecting agents
    Patent number: 6579877
    Abstract: The use of a protecting agent, for example a folate derivative such as folic acid or leucovorin, in combination with a non-competitive folic acid analogue, for example benzoquinazoline derivatives, for use in reducing the side effects associated with the administration of such non-competitive folic acid analogues, and pharmaceutical formulations comprising such combinations are disclosed.
    Type: Grant
    Filed: March 18, 2002
    Date of Patent: June 17, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Gary Keith Smith, David Stanley Duch, Robert Ferone, Arthur Koch
  • Viral cell death protein and uses therefor
    Publication number: 20030082527
    Abstract: Viral proteins with sequence and functional similarity to the drosophila cell death protein known as Reaper are provided. Reaper plays an important role in the apoptotic pathway. Methods using the viral proteins and nucleotides encoding such proteins are described.
    Type: Application
    Filed: August 5, 2002
    Publication date: May 1, 2003
    Inventor: Gary Keith Smith
  • Novel combination of benzoquinazoline antifolates and protecting agents
    Publication number: 20020137748
    Abstract: The use of a protecting agent, for example a folate derivative such as folic acid or leucovorin, in combination with a non-competitive folic acid analogue, for example benzoquinazoline derivatives, for use in reducing the side effects associated with the administration of such non-competitive folic acid analogues, and pharmaceutical formulations comprising such combinations are disclosed.
    Type: Application
    Filed: March 18, 2002
    Publication date: September 26, 2002
    Inventors: Gary Keith Smith, David Stanley Duch, Robert Ferone, Arthur Koch
  • Combination of benzoquinazoline antifolates and protecting agents
    Patent number: 6358952
    Abstract: The use of a protecting agent, for example a folate derivative such as folic acid or leucovorin, in combination with a non-competitive folic acid analogue, for example benzoquinazoline derivatives, for use in reducing the side effects associated with the administration of such non-competitive folic acid analogues, and pharmeceutical formulations comprising such combinations are disclosed.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: March 19, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Gary Keith Smith, David Stanley Duch, Robert Ferone, Arthur Koch
  • Nucleic acids encoding mutant human carboxypeptidase A enzymes
    Patent number: 6319702
    Abstract: The present invention relates to nucleic acid molecules encoding mutant human carboxypeptidase A enzymes, and encoding conjugates of targeting molecules and mutant human carboxypeptidase A enzymes. The invention further relates to vectors and cell lines containing such nucleic acid molecules.
    Type: Grant
    Filed: September 14, 1999
    Date of Patent: November 20, 2001
    Assignee: Glaxo Wellcome, Inc.
    Inventors: Gary Keith Smith, Todd Andrew Blumenkopf, Michael Cory
  • Cell-targeting molecule comprising a mutant human carboxypeptidase A
    Patent number: 6140100
    Abstract: Conjugates of a cell targetting molecule and a mutant human carboxypeptidase A enzyme are provided. Suitable targetting molecules include antibodies, hormones, ligands, cytokines, antigens, oligonucleotides and peptidomimetics. Enzymes comprising a mutant human carboxypeptidase A enzyme are also provided.
    Type: Grant
    Filed: May 9, 1996
    Date of Patent: October 31, 2000
    Assignee: Glaxo Wellcome Inc.
    Inventors: Gary Keith Smith, Todd Andrew Blumenkopf, Michael Cory