Abstract: Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.

Abstract: Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.

Abstract: A connector block for retaining at least one shock tube in signal transfer relationship with a detonator. The connector block comprises a housing (2, 21) having a bore (4, 23) formed therein for receiving a detonator (6, 36) provided with a percussion-actuation end (7, 25), a shock tube retention means (8, 28) defining with the housing a slot (9, 29) for receiving therein at least one shock tube (10, 30) and holding the at least one shock tube in signal transfer relationship with the percussion-actuation end of the detonator present in the bore, the slot having an entrance (12, 32) for allowing insertion of the at least one shock tube into the slot, and a flexible and resilient closure member (11, 31) or an inflexible closure member (50) pivotable on a sprung hinge (51) extending partially or fully into the entrance.

Abstract: A connector block for retaining at least one shock tube in signal transfer relationship with a detonator. The connector block comprises a housing (2, 21) having a bore (4, 23) formed therein for receiving a detonator (6, 36) provided with a percussion-actuation end (7, 25), a shock tube retention means (8, 28) defining with the housing a slot (9, 29) for receiving therein at least one shock tube (10, 30) and holding the at least one shock tube in signal transfer relationship with the percussion-actuation end of the detonator present in the bore, the slot having an entrance (12, 32) for allowing insertion of the at least one shock tube into the slot, and a flexible and resilient closure member (11, 31) or an inflexible closure member (50) pivotable on a sprung hinge (51) extending partially or fully into the entrance.

Abstract: A connector block for retaining at least one shock tube in signal transfer relationship with a detonator. The connector block comprises a housing (2, 21) having a bore (4, 23) formed therein for receiving a detonator (6, 36) provided with a percussion-actuation end (7, 25), a shock tube retention means (8, 28) defining with the housing a slot (9, 29) for receiving therein at least one shock tube (10, 30) and holding the at least one shock tube in signal transfer relationship with the percussion-actuation end of the detonator present in the bore, the slot having an entrance (12, 32) for allowing insertion of the at least one shock tube into the slot, and a flexible and resilient closure member (11, 31) or an inflexible closure member (50) pivotable on a sprung hinge (51) extending partially or fully into the entrance.