Patents by Inventor Gary Koe

Gary Koe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for preparing polynucleotide transfection complexes
    Patent number: 6303378
    Abstract: Methods are provided for the preparation of transfection complexes of polynucleotides and polycations, especially cationic lipids, suitable for delivering polynucleotides to cells. In particular, methods are provided for preparing transfection complexes using a reduced-volume, dual-feed process. Complexes are formed upon the collision of two feed stream, containing polynucleotides and polycation, respectively, under conditions resulting in turbulent mixing conditions in minimal volume, and removal of transfection complexes under laminar flow conditions. Alternatively, the components are mixed in a static mixer. The process is easily scaleable and highly reproducible.
    Type: Grant
    Filed: October 23, 1998
    Date of Patent: October 16, 2001
    Assignee: Valentis, Inc.
    Inventors: Robert Bridenbaugh, Warren Dang, Gary Koe
  • Methods for preparing polynucleotide transfection complexes
    Patent number: 6114169
    Abstract: Methods are provided for the preparation of transfection complexes of polynucleotides and polycations, especially cationic lipids, suitable for delivering polynucleotides to cells. In particular, methods are provided for preparing transfection complexes using a reduced-volume, dual-feed process. Complexes are formed upon the collision of two feed stream, containing polynucleotides and polycation, respectively, under conditions resulting in turbulent mixing conditions in minimal volume, and removal of transfection complexes under laminar flow conditions. Alternatively, the components are mixed in a static mixer. The process is easily scaleable and highly reproducible.
    Type: Grant
    Filed: October 23, 1998
    Date of Patent: September 5, 2000
    Assignee: Valentis, Inc.
    Inventors: Robert Bridenbaugh, Warren Dang, Gary Koe