Patents by Inventor Gary L. Bolton

Gary L. Bolton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS INCLUDING AN ANTI-INFLAMMATORY PHARMACORE AND METHODS OF USE
    Publication number: 20100048887
    Abstract: This invention provides novel compounds comprising the following anti-inflammatory pharmacore: wherein X, R1 and R2 are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds, methods and intermediates useful for making the compounds, and methods of using the compounds and compositions.
    Type: Application
    Filed: April 20, 2009
    Publication date: February 25, 2010
    Inventors: Eric Anderson, Gary L. Bolton, Deborah A. Ferguson, Xin Jiang, Robert M. Kral, JR., Patrick M. O'Brien, Melean Visnick
  • Rapid purification by polymer supported quench
    Patent number: 6506701
    Abstract: Novel polymer-supported quenching reagents of Formula I, P—L—Q  I wherein P is a polymer of low chemical reactivity which is soluble or insoluble; Q is one or more quenching reagents, or an acid or base addition salts thereof, that are capable of selective covalent reaction with unwanted byproducts, or excess reagents; and L is one or more chemically robust linkers that join P and Q; are described, as well as methods for their preparation and methods for their use in the rapid purification of synthetic intermediates and products in organic synthesis, combinatorial chemistry and automated organic synthesis.
    Type: Grant
    Filed: March 13, 2001
    Date of Patent: January 14, 2003
    Assignee: Warner-Lambert Company
    Inventors: Gary L. Bolton, Richard J. Booth, Mark W. Creswell, John C. Hodges, Joseph S. Warmus, Michael W. Wilson
  • Rapid purification by polymer supported quench
    Patent number: 6306959
    Abstract: Novel polymer-supported quenching reagents of Formula (I): P-L-Q, wherein P is a polymer of low chemical reactivity which is soluble or insoluble; Q is one or more quenching reagents, or an acid or base addition salts thereof, that are capable of selective covalent reaction with unwanted byproducts, or excess reagents; and L is one or more chemically robust linkers that join P and Q; are described, as well as methods for their preparation and methods for their use in the rapid purification of synthetic intermediates and products in organic synthesis, combinatorial chemistry and automated organic synthesis.
    Type: Grant
    Filed: October 15, 1998
    Date of Patent: October 23, 2001
    Assignee: Warner Lambert Company
    Inventors: Gary L. Bolton, Richard J. Booth, Mark W. Creswell, John C. Hodges, Joseph S. Warmus, Michael W. Wilson
  • Tricyclic inhibitors of protein farnesyltransferase
    Patent number: 5919780
    Abstract: Compounds of formula I ##STR1## wherein X is N or C--R.sup.9, Y is N--R.sup.10, CH.sub.2, O, S, SO, SO.sub.2, C.dbd.O or CH--OH,R is H or alkyl,R.sup.1 is heteroaryl,n is 1-5, andR.sup.2 -R.sup.10 are H or various substituents,are useful as inhibitors of protein farnesyl transferase and for the treatment of proliferative diseases including cancer, restenosis and psoriasis, and as antiviral agents.
    Type: Grant
    Filed: December 11, 1997
    Date of Patent: July 6, 1999
    Assignee: Warner Lambert Company
    Inventors: Gary L. Bolton, Annette M Doherty, James S. Kaltenbronn, John Quin, III, Jeffrey D. Scholten, Judith Sebolt-Leopold, Harold Zinnes
  • Isothiazolones
    Patent number: 5620997
    Abstract: Isothiazolones having the general structure ##STR1## where A is a monocyclic or bicyclic ring which may contain up to 3 heteroatoms selected from O, S, and N; R.sup.1 and R.sup.2 are substituent groups such as alkyl, alkoxy, hydroxy, nitro, cyano, amino, and carboxy; and R.sup.5 is alkyl, cycloalkyl, phenyl, and Het. The isothiazolones are useful as anti-retroviral agents, anti-inflammatory agents, and anti-atherosclerotic agents.
    Type: Grant
    Filed: May 31, 1995
    Date of Patent: April 15, 1997
    Assignee: Warner-Lambert Company
    Inventors: Gary L. Bolton, John M. Domagala, Edward F. Elslager, Rocco D. Gogliotti, Terri S. Purchase, Joseph P. Sanchez, Bharat K. Trivedi
  • Histidine and homohistidine derivatives as inhibitors of protein farnesyltransferase
    Patent number: 5571792
    Abstract: Novel inhibitors of protein farnesyltransferase enzyme are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in controlling tissue proliferative diseases, including cancer and restenosis.
    Type: Grant
    Filed: June 30, 1994
    Date of Patent: November 5, 1996
    Assignee: Warner-Lambert Company
    Inventors: Gary L. Bolton, John C. Hodges, Michael W. Wilson
  • Phosphorus containing compounds as antihypercholesterolemic and antiatherosclerotic agents
    Patent number: 5208224
    Abstract: Novel phosphorus containing compounds are described, as well as methods for the preparation and pharmaceutical composition of same, which are useful in preventing the intestinal absorption of cholesterol and thus are useful in the treatment of hypercholesterolemia and atherosclerosis.
    Type: Grant
    Filed: March 13, 1991
    Date of Patent: May 4, 1993
    Assignee: Warner-Lambert Company
    Inventors: Gary L. Bolton, Janak K. Padia, Bharat K. Trivedi