Patents by Inventor Gary L. Cantrell

Gary L. Cantrell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation of 3,4-dihydroisoquinolines in the synthesis of morphinans
    Patent number: 8232400
    Abstract: The present invention is directed to processes for the synthesis of morphinans. In particular, a process for coupling a carboxylic acid compound with an amine compound to form an amide product that can then be isolated or the crude amide product can be cyclized to form a 3,4-dihydroisoquinoline. In one embodiment, the carboxylic acid contains a phenol moiety protected with a labile protecting group. The protected phenol reduces reaction times, simplifies work-up of the product, and reduces the amount of cyclizing agent, POCl3 that is necessary to form the 3,4-dihydroisoquinoline.
    Type: Grant
    Filed: June 10, 2009
    Date of Patent: July 31, 2012
    Assignee: Mallinckrodt LLC
    Inventors: Peter X. Wang, Frank W. Moser, Christopher W. Grote, Gary L. Cantrell
  • Process for the preparation of hexahydroisoquinolines from 1,2,3,4-tetrahydroisoquinolines
    Patent number: 8227611
    Abstract: The present invention is directed to processes for the synthesis of morphinans. In particular, a process for the asymmetric reduction of an imine moiety in a 3,4-dihydroisoquinoline to produce a tetrahydroisoquinoline, followed by a Birch reduction to produce a hexahydroisoquinoline. In various embodiments, the 3,4-dihydroisoquinoline contains a phenol moiety protected with a labile protecting group. In other embodiments, the imine reduction reaction mixture contains silver tetrafluoroborate.
    Type: Grant
    Filed: June 10, 2009
    Date of Patent: July 24, 2012
    Assignee: Mallinckrodt LLC
    Inventors: Gary L. Cantrell, Dan P. Magparangalan, Frank W. Moser, Jian Bao, Christopher W. Grote, Peter X. Wang
  • Preparation of oxymorphone from oripavine
    Patent number: 8217175
    Abstract: An improved method for the preparation of oxymorphone from oripavine is provided. Oripavine is oxidized to form 14-hydroxymorphinone after which the oxidation reaction is quenched to prevent the formation of 1-1?-dimer side products. The 14-hydroxymorphinone is then reduced, typically by catalytic hydrogenation to form oxymorphone. The inventive method disclosed is further applicable to the production of morphinan derivatives.
    Type: Grant
    Filed: March 14, 2008
    Date of Patent: July 10, 2012
    Assignee: Mallinckrodt LLC
    Inventors: Peter X. Wang, Tao Jiang, Gary L. Cantrell, David Wayne Berberich
  • Compounds and Compositions for Use in Phototherapy and in Treatment of Ocular Neovascular Disease and Cancers
    Publication number: 20120129879
    Abstract: The invention relates generally to anti-angiogenesis agents and related methods of using to anti-angiogenesis agents for biomedical applications including direct monotherapy and combination therapy for treatment of an angiogenesis related condition. In an embodiment, the invention provides a class of opioid compounds and structurally related opioid derivatives exhibiting anti-VEGF activity for use in therapeutic procedures, including phototherapy. Opioid compounds and structurally related opioid derivatives of the invention may be administered alone or in combination with administration of a phototherapy agent and/or other therapeutic agent.
    Type: Application
    Filed: July 16, 2010
    Publication date: May 24, 2012
    Inventors: Gary L. Cantrell, Raghavan Rajagopalan, David W. Berberich, Amolkumar Karwa, Richard B. Dorshow
  • Sinomenine Derivatives and Processes for their Synthesis
    Publication number: 20120116086
    Abstract: The invention generally provides processes and intermediate compounds useful for the production of sinomenine derivatives. In particular, the process may encompass synthetic routes for the production of (+)-sinomenine derivatives and their intermediates.
    Type: Application
    Filed: January 18, 2012
    Publication date: May 10, 2012
    Applicant: Mallinckrodt LLC
    Inventors: Peter X. Wang, Tao Jiang, Gary L. Cantrell, David W. Berberich, Bobby N. Trawick, Subo Liao, John Brandt
  • Process for the preparation of 6-beta hydroxy morphinan compounds
    Patent number: 8168790
    Abstract: The invention provides processes for the conversion of a 6-keto morphinan to a 6-hydroxy morphinan. In particular, the invention provides a stereoselective process for the conversion of a 6-keto morphinan to a 6-beta-hydroxy morphinan.
    Type: Grant
    Filed: June 16, 2009
    Date of Patent: May 1, 2012
    Assignee: Mallinckrodt LLC
    Inventors: Jian Bao, Tao Jiang, Gary L. Cantrell
  • Processes and compounds for the preparation of normorphinans
    Patent number: 8148528
    Abstract: The invention generally provides processes and intermediate compounds useful for the production of normorphinans and derivatives of normorphinans.
    Type: Grant
    Filed: May 21, 2009
    Date of Patent: April 3, 2012
    Assignee: Mallinckrodt LLC
    Inventors: Peter X. Wang, Frank W. Moser, Gary L. Cantrell, Tao Jiang, Robert E. Halvachs, Christopher W. Grote
  • Preparation of substituted morphinan-6-ones and salts and intermediates thereof
    Patent number: 8115002
    Abstract: The present invention is directed to processes for the synthesis of morphinan-6-ones and salts, intermediates, and analogs thereof.
    Type: Grant
    Filed: September 6, 2007
    Date of Patent: February 14, 2012
    Assignee: Mallinckrodt LLC
    Inventors: Peter X. Wang, Frank W. Moser, Gary L. Cantrell, Christopher W. Grote
  • Processes for the preparation of normorphinan salts
    Patent number: 8101757
    Abstract: The invention provides a process for the conversion of opioid derivatives into normorphinan compounds useful for making “nal” compound analgesics and antagonists. In particular, the process may be used for the production of pure normorphinan salts from crude opioid substrates.
    Type: Grant
    Filed: December 17, 2008
    Date of Patent: January 24, 2012
    Assignee: Mallinckrodt LLC
    Inventors: Peter X. Wang, Tao Jiang, Gary L. Cantrell, David W. Berberich, Jian Bao, Bobby N. Trawick
  • Processes for the production of (+)- “Nal” morphinan compounds
    Patent number: 8067596
    Abstract: The invention generally provides processes and intermediate compounds useful for the production of (+) nal morphinan compounds. In particular, the process encompasses synthetic routes for the production of (+) nal morphinan compounds or derivatives of (+) nal morphinan compounds from (+)-morphinan substrates such as (+)-hydrocodone, (+)-norhydrocodone or derivatives of either compound.
    Type: Grant
    Filed: December 17, 2008
    Date of Patent: November 29, 2011
    Assignee: Mallinckrodt LLC
    Inventors: Peter X. Wang, Tao Jiang, Gary L. Cantrell, David W. Berberich, Bobby N. Trawick, Subo Liao
  • Synthetic route to 14-hydroxyl opiates through 1-halo-thebaine or analogs
    Patent number: 8067597
    Abstract: Novel methods of synthesis of known and novel 14-hydroxyl opiates through 1-halothebaine and derivatives are described.
    Type: Grant
    Filed: May 22, 2006
    Date of Patent: November 29, 2011
    Assignee: Mallinckrodt LLC
    Inventors: Peter X. Wang, Frank W. Moser, Gary L. Cantrell, Daniel P. Magparangalan, Jian Bao
  • Process for the preparation of buprenorphine and derivatives for buprenorphine
    Patent number: 8017777
    Abstract: The invention generally provides processes for the production of buprenophine and derivatives of buprenorphine. In particular, the process may encompass synthetic routes for the production of buprenorphine or derivatives of buprenorphine from norhydromorphone or derivatives of norhydromorphone.
    Type: Grant
    Filed: December 17, 2008
    Date of Patent: September 13, 2011
    Assignee: Mallinckrodt LLC
    Inventors: Peter X. Wang, Tao Jiang, Gary L. Cantrell, David W. Berberich, Bobby N. Trawick, Subo Liao
  • Process for the preparation of 3-hydroxymorphinan derivatives
    Patent number: 7999105
    Abstract: Processes are described for the synthesis of 3-hydroxymorphinan derivatives by hydrolysis of side products from the O-demethylation of 3-methoxymorphinan derivatives.
    Type: Grant
    Filed: February 18, 2009
    Date of Patent: August 16, 2011
    Assignee: Mallinckrodt Inc.
    Inventors: Peter X. Wang, Tao Jiang, Gary L. Cantrell, David W. Berberich, Frank W. Moser, Jian Bao
  • Process for the preparation of 6-alpha-hydroxy-N-alkylated opiates
    Patent number: 7985858
    Abstract: The present invention is directed to the conversion of a 6-keto morphinan to a 6-alpha-hydroxy morphinan in the presence of a ruthenium, rhodium, or iridium asymmetric catalyst and a hydrogen source.
    Type: Grant
    Filed: May 2, 2008
    Date of Patent: July 26, 2011
    Assignee: Mallinckrodt Inc.
    Inventors: Christopher W. Grote, Peter X. Wang, Tao Jiang, Gary L. Cantrell, Frank W. Moser, Catherine E. Thomasson
  • Process for the Preparation of Quaternary N-Alkyl Morphinan Alkaloid Salts
    Publication number: 20110082297
    Abstract: An improved process for the N-alkylation of tertiary morphinan alkaloid bases to form the corresponding quaternary morphinan alkaloid derivatives.
    Type: Application
    Filed: March 6, 2008
    Publication date: April 7, 2011
    Inventors: Peter X. Wang, Gary L. Cantrell, Robert E. Halvachs, Kevin R. Roesch, Henry J. Buehler, Joseph P. Haar, JR.
  • Sustained-Release Opiate and Opiate Derivative Compositions
    Publication number: 20110077222
    Abstract: The present invention provides sustained-release opiate compositions. In particular, the present invention provides sustained-release opiate compositions that include an opiate attached to a blood albumin binder. The present invention also relates to methods of administering an opiate with a sustained release pharmacokinetic profile.
    Type: Application
    Filed: September 30, 2010
    Publication date: March 31, 2011
    Applicant: Mallinckrodt Inc.
    Inventors: Carl J. Schaefer, Gary L. Cantrell
  • One-Pot Preparation of Hexahydroisoquinolines from Amides
    Publication number: 20110071299
    Abstract: The present invention provides an efficient process for the preparation of hexahydroisoquinolines from amides. In particular, the invention provides a good yielding, one-pot process for the synthesis of hexahydroisoquinolines.
    Type: Application
    Filed: September 24, 2010
    Publication date: March 24, 2011
    Applicant: Mallinckrodt Inc.
    Inventors: Christopher W. Grote, Frank W. Moser, Peter X. Wang, Gary L. Cantrell, David W. Berberich
  • One-Pot Preparation of Hexahydroisoquinolines from Dihydroisoquinolines
    Publication number: 20110071300
    Abstract: The present invention provides an efficient process for the preparation of hexahydroisoquinolines from dihydroisoquinolines. In particular, the invention provides a good yielding, one-pot process for the synthesis of hexahydroisoquinolines.
    Type: Application
    Filed: September 24, 2010
    Publication date: March 24, 2011
    Applicant: Mallinckrodt Inc.
    Inventors: Christopher W. Grote, Frank W. Moser, Peter X. Wang, Gary L. Cantrell, David W. Berberich
  • 3-Oxy-Hydromorphone Derivatives
    Publication number: 20110015398
    Abstract: The present invention provides 3-oxy-hydromorphone derivatives, and in particular, 3-ester, 3-carbonate, and 3-sulfonate derivatives of hydromorphone.
    Type: Application
    Filed: July 9, 2010
    Publication date: January 20, 2011
    Applicant: Mallinckrodt Inc.
    Inventors: Gary L. Cantrell, Robert E. Halvachs, Frank W. Moser, David W. Berberich, Peter X. Wang
  • Crystalline Forms of Naltrexone Methobromide
    Publication number: 20100324078
    Abstract: The present invention relates to novel crystalline forms of naltrexone methobromide including hydrated and solvated forms. The invention also describes methods of preparing the various crystalline forms. The present invention also relates to pharmaceutical compositions containing crystalline forms of naltrexone methobromide, as well as methods of treating or preventing opioid induced side effects by administering the pharmaceutical compositions.
    Type: Application
    Filed: June 25, 2008
    Publication date: December 23, 2010
    Inventors: Gary A. Nichols, Robert E. Halvachs, Gary L. Cantrell, Kevin R. Roesch, Joseph P. Haar, JR.