Patents by Inventor Gary L. Long
Gary L. Long has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220395323Abstract: Apparatuses, systems and methods are provided for treating pulmonary tissues via delivery of energy, generally characterized by high voltage pulses, to target tissue using a pulmonary tissue modification system (e.g., an energy delivery catheter system). Example pulmonary tissues include, without cells), lamina propria, submucosa, submucosal glands, basement membrane, smooth muscle, cartilage, nerves, pathogens resident near or within the tissue, or a combination of any of these. The system may be used to treat a variety of pulmonary diseases or disorders such as or associated with COPD (e.g., chronic bronchitis, emphysema), asthma, interstitial pulmonary fibrosis, cystic fibrosis, bronchiectasis, primary ciliary dyskinesia (PCD), acute bronchitis and/or other pulmonary diseases or disorders.Type: ApplicationFiled: May 25, 2022Publication date: December 15, 2022Applicant: Galvanize Therapeutics, Inc.Inventors: Jonathan Reuben WALDSTREICHER, William Sanford KRIMSKY, Denise Marie ZARINS, Robert J. BEETEL, III, Paul Brian FRIEDRICHS, Kevin James TAYLOR, Roman TUROVSKIY, Gary L. LONG
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Patent number: 11369433Abstract: Apparatuses, systems and methods are provided for treating pulmonary tissues via delivery of energy, generally characterized by high voltage pulses, to target tissue using a pulmonary tissue modification system (e.g., an energy delivery catheter system). Example pulmonary tissues include, without cells), lamina propria, submucosa, submucosal glands, basement membrane, smooth muscle, cartilage, nerves, pathogens resident near or within the tissue, or a combination of any of these. The system may be used to treat a variety of pulmonary diseases or disorders such as or associated with COPD (e.g., chronic bronchitis, emphysema), asthma, interstitial pulmonary fibrosis, cystic fibrosis, bronchiectasis, primary ciliary dyskinesia (PCD), acute bronchitis and/or other pulmonary diseases or disorders.Type: GrantFiled: December 20, 2018Date of Patent: June 28, 2022Assignee: Galvanize Therapeutics, Inc.Inventors: Jonathan Reuben Waldstreicher, William Sanford Krimsky, Denise Marie Zarins, Robert J. Beetel, III, Paul Brian Friedrichs, Kevin James Taylor, Roman Turovskiy, Gary L. Long
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Publication number: 20220000547Abstract: Catheter systems, tools and methods are disclosed for the selective and rapid application of DC voltage to drive irreversible electroporation, with the system controller configurable to apply voltages to an independently selected subsets of electrodes, such that voltages of one polarity are applied to a multiplicity of electrodes on a first medical device and voltages of the opposite polarity to a multiplicity of electrodes on a second medical device. The first and second medical devices can be epicardial catheters positioned such that their opposing distal tips are approximately aligned and whose segments with electrodes collectively wrap around the pulmonary veins.Type: ApplicationFiled: March 19, 2021Publication date: January 6, 2022Applicant: Farapulse, Inc.Inventor: Gary L. LONG
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Publication number: 20220000546Abstract: Systems, devices, and methods for electroporation ablation therapy are disclosed herein, including an inflatable member for positioning an ablation device within a pulmonary vein ostium. An apparatus can include first and second shafts moveable relative to one another, first and second electrodes configured to generate an electric field for ablating tissue, and an inflatable member disposed between the first and second electrodes. In some embodiments, the inflatable member is configured to transition from an undeployed configuration to a deployed configuration in response to movement of the first and second shafts. In some embodiments, the inflatable member in the deployed configuration can engage a wall of a pulmonary vein ostium and direct the electric field generated by the first and second electrodes toward the wall.Type: ApplicationFiled: March 19, 2021Publication date: January 6, 2022Applicant: Farapulse, Inc.Inventors: Raju VISWANATHAN, Gary L. LONG, Jean-Luc PAGEARD, Benoit THIBAULT
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Publication number: 20210236815Abstract: Apparatuses, systems and methods are provided for treating pulmonary tissues via delivery of energy, generally characterized by high voltage pulses, to target tissue using a pulmonary tissue modification system (e.g., an energy delivery catheter system). Example pulmonary tissues include, without limitation, those within the respiratory tract, particularly the epithelium (the goblet cells, ciliated pseudostratified columnar epithelial cells, and basal cells), lamina propria, submucosa, submucosal glands, basement membrane, smooth muscle, cartilage, nerves, pathogens resident near or within the tissue, or a combination of any of these. The systems may be used to treat pathogens, such as bacteria and viruses, particularly coronaviruses.Type: ApplicationFiled: March 25, 2021Publication date: August 5, 2021Applicant: Galary, Inc.Inventors: Jonathan R. Waldstreicher, William S. Krimsky, Robert E. Neal, II, Denise M. Zarins, Robert J. Beetel, Paul Brian Friedrichs, Kevin James Taylor, Roman Turovskiy, Gary L. Long
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Publication number: 20210236816Abstract: Apparatuses, systems and methods are provided for treating pulmonary tissues via delivery of energy, generally characterized by high voltage pulses, to target tissue using a pulmonary tissue modification system (e.g., an energy delivery catheter system). Example pulmonary tissues include, without limitation, the epithelium (the goblet cells, ciliated pseudostratified columnar epithelial cells, and basal cells), lamina propria, submucosa, submucosal glands, basement membrane, smooth muscle, cartilage, nerves, pathogens resident near or within the tissue, or a combination of any of these. The system may be used to treat a variety of pulmonary diseases or disorders such as or associated with COPD (e.g., chronic bronchitis, emphysema), asthma, interstitial pulmonary fibrosis, cystic fibrosis, bronchiectasis, primary ciliary dyskinesia (PCD), acute bronchitis and/or other pulmonary diseases or disorders.Type: ApplicationFiled: March 26, 2021Publication date: August 5, 2021Applicant: Galary, Inc.Inventors: Jonathan Reuben Waldstreicher, William Sanford Krimsky, Denise M. Zarins, Robert J. Beetel, Paul Brian Friedrichs, Kevin James Taylor, Roman Turovskiy, Gary L. Long, Robert E. Neal, II
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Publication number: 20210146126Abstract: Apparatuses, systems and methods are provided for treating pulmonary tissues via delivery of energy, generally characterized by high voltage pulses, to target tissue using a pulmonary tissue modification system (e.g., an energy delivery catheter system). Example pulmonary tissues include, without limitation, the epithelium (the goblet cells, ciliated pseudostratified columnar epithelial cells, and basal cells), lamina propria, submucosa, submucosal glands, basement membrane, smooth muscle, cartilage, nerves, pathogens resident near or within the tissue, or a combination of any of these. The system may be used to treat a variety of pulmonary diseases or disorders such as or associated with COPD (e.g., chronic bronchitis, emphysema), asthma, interstitial pulmonary fibrosis, cystic fibrosis, bronchiectasis, primary ciliary dyskinesia (PCD), acute bronchitis and/or other pulmonary diseases or disorders.Type: ApplicationFiled: June 26, 2020Publication date: May 20, 2021Applicant: Galary, Inc.Inventors: Jonathan Reuben Waldstreicher, William Sanford Krimsky, Denise M. Zarins, Robert J. Beetel, Paul Brian Friedrichs, Kevin James Taylor, Roman Turovskiy, Gary L. Long, Robert E. Neal, II
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Publication number: 20210137592Abstract: Systems, devices, and methods for electroporation ablation therapy are disclosed, with the system including a pulse waveform signal generator for medical ablation therapy, and an endocardial ablation device includes an inflatable member and at least one electrode for focal ablation pulse delivery to tissue. The signal generator may deliver voltage pulses to the ablation device in the form of a pulse waveform. The system may include a cardiac stimulator for generation of pacing signals and for sequenced delivery of pulse waveforms in synchrony with the pacing signal.Type: ApplicationFiled: January 15, 2021Publication date: May 13, 2021Applicant: Farapulse, Inc.Inventors: Raju VISWANATHAN, Gary L. LONG
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Patent number: 10939958Abstract: Apparatuses, systems and methods are provided for treating pulmonary tissues via delivery of energy, generally characterized by high voltage pulses, to target tissue using a pulmonary tissue modification system (e.g., an energy delivery catheter system). Example pulmonary tissues include, without limitation, the epithelium (the goblet cells, ciliated pseudostratified columnar epithelial cells, and basal cells), lamina propria, submucosa, submucosal glands, basement membrane, smooth muscle, cartilage, nerves, pathogens resident near or within the tissue, or a combination of any of these. The system may be used to treat a variety of pulmonary diseases or disorders such as or associated with COPD (e.g., chronic bronchitis, emphysema), asthma, interstitial pulmonary fibrosis, cystic fibrosis, bronchiectasis, primary ciliary dyskinesia (PCD), acute bronchitis and/or other pulmonary diseases or disorders.Type: GrantFiled: June 10, 2020Date of Patent: March 9, 2021Assignee: Galary, Inc.Inventors: Jonathan Reuben Waldstreicher, William Sanford Krimsky, Denise Marie Zarins, Robert J. Beetel, III, Paul Brian Friedrichs, Kevin James Taylor, Roman Turovskiy, Gary L. Long
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Publication number: 20210045798Abstract: Systems, devices, and methods for electroporation ablation therapy are disclosed, with the device including a first jaw including a plurality of first electrodes and a second jaw including a plurality of second electrodes. The first jaw and the second jaw may be substantially rigid, elongate, and collectively define a longitudinal axis. The first jaw and the second jaw may be configured to engage tissue therebetween during use.Type: ApplicationFiled: November 2, 2020Publication date: February 18, 2021Applicant: Farapulse, Inc.Inventors: Raju VISWANATHAN, Gary L. LONG
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Patent number: 10893905Abstract: Systems, devices, and methods for electroporation ablation therapy are disclosed, with the system including a pulse waveform signal generator for medical ablation therapy, and an endocardial ablation device includes an inflatable member and at least one electrode for focal ablation pulse delivery to tissue. The signal generator may deliver voltage pulses to the ablation device in the form of a pulse waveform. The system may include a cardiac stimulator for generation of pacing signals and for sequenced delivery of pulse waveforms in synchrony with the pacing signal.Type: GrantFiled: March 12, 2020Date of Patent: January 19, 2021Assignee: Farapulse, Inc.Inventors: Raju Viswanathan, Gary L. Long
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Publication number: 20200397505Abstract: Systems, devices, and methods for electroporation ablation therapy are disclosed. An apparatus may include a linear shaft including a distal portion positionable near a tissue wall. The linear shaft can be configured to deflect to position the distal portion near the tissue wall. The apparatus can include a plurality of electrodes disposed on the distal portion of the linear shaft, where the plurality of electrodes are configured to generate a pulsed electric field that produces an ablation zone in the tissue wall having a depth that is independent of an orientation of the distal portion relative to the tissue wall.Type: ApplicationFiled: March 24, 2020Publication date: December 24, 2020Applicant: Farapulse, Inc.Inventors: Raju VISWANATHAN, Gary L. LONG
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Publication number: 20200398048Abstract: Methods, systems and devices are provided which transmit energy to a body lumen or passageway in the form of pulsed electric fields (PEFs) and in a manner which provides focal therapy. In some embodiments, PEFs are delivered through independent electrically active electrodes of an energy delivery body, typically in a monopolar fashion. Such delivery concentrates the electrical energy over a smaller surface area, resulting in stronger effects than delivery through an electrode extending circumferentially around the lumen or passageway. It also forces the electrical energy to be delivered in a staged regional approach, mitigating the effect of preferential current pathways through the surrounding tissue. Focal delivery of PEFs can provide increased tissue lethality by employing precise timing and sequencing of energy delivery to the electrodes.Type: ApplicationFiled: June 26, 2020Publication date: December 24, 2020Applicant: Galary, Inc.Inventors: William Sanford Krimsky, Denise M. Zarins, Robert J. Beetel, Paul Brian Friedrichs, Roman Turovskiy, Gary L. Long, Robert E. Neal, II, Jonathan Reuben Waldstreicher, Kevin James Taylor
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Publication number: 20200323586Abstract: Apparatuses, systems and methods are provided for treating pulmonary tissues via delivery of energy, generally characterized by high voltage pulses, to target tissue using a pulmonary tissue modification system (e.g., an energy delivery catheter system). Example pulmonary tissues include, without limitation, the epithelium (the goblet cells, ciliated pseudostratified columnar epithelial cells, and basal cells), lamina propria, submucosa, submucosal glands, basement membrane, smooth muscle, cartilage, nerves, pathogens resident near or within the tissue, or a combination of any of these. The system may be used to treat a variety of pulmonary diseases or disorders such as or associated with COPD (e.g., chronic bronchitis, emphysema), asthma, interstitial pulmonary fibrosis, cystic fibrosis, bronchiectasis, primary ciliary dyskinesia (PCD), acute bronchitis and/or other pulmonary diseases or disorders.Type: ApplicationFiled: June 10, 2020Publication date: October 15, 2020Applicant: Galary, Inc.Inventors: Jonathan Reuben WALDSTREICHER, William Sanford KRIMSKY, Denise Marie ZARINS, Robert J. BEETEL, III, Paul Brian FRIEDRICHS, Kevin James TAYLOR, Roman TUROVSKIY, Gary L. LONG
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Patent number: 10779882Abstract: An electrical ablation apparatus including first, second, and third electrodes is disclosed. Each of the first and second electrode is configured to be selectively extended outside and selectively retracted inside a distal end of its respective lumen and is configured to diverge from its respective longitudinal axis when extended outside the distal end of its respective lumen. The third electrode is non-rotatable and is configured to be selectively extended outside and selectively retracted inside a distal end of its respective lumen. The first, second and third electrodes are extendable into a tissue treatment region to create a first necrotic zone having a first shape. At least one of the first electrode or the second electrode is selectively rotatable within its respective lumen to create a second necrotic zone having a second shape. The third electrode is configured to positionally secure the electrical ablation apparatus at the tissue treatment region.Type: GrantFiled: August 29, 2016Date of Patent: September 22, 2020Assignee: ETHICON ENDO-SURGERY, INC.Inventors: Gary L. Long, David N. Plescia, Omar J. Vakharia
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Patent number: 10702337Abstract: Apparatuses, systems and methods are provided for treating pulmonary tissues via delivery of energy, generally characterized by high voltage pulses, to target tissue using a pulmonary tissue modification system (e.g., an energy delivery catheter system). Example pulmonary tissues include, without limitation, the epithelium (the goblet cells, ciliated pseudostratified columnar epithelial cells, and basal cells), lamina propria, submucosa, submucosal glands, basement membrane, smooth muscle, cartilage, nerves, pathogens resident near or within the tissue, or a combination of any of these. The system may be used to treat a variety of pulmonary diseases or disorders such as or associated with COPD (e.g., chronic bronchitis, emphysema), asthma, interstitial pulmonary fibrosis, cystic fibrosis, bronchiectasis, primary ciliary dyskinesia (PCD), acute bronchitis and/or other pulmonary diseases or disorders.Type: GrantFiled: April 11, 2019Date of Patent: July 7, 2020Assignee: Galary, Inc.Inventors: Jonathan Reuben Waldstreicher, William Sanford Krimsky, Denise Marie Zarins, Robert J. Beetel, III, Paul Brian Friedrichs, Kevin James Taylor, Roman Turovskiy, Gary L. Long
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Publication number: 20200205892Abstract: Systems, devices, and methods for electroporation ablation therapy are disclosed, with the system including a pulse waveform signal generator for medical ablation therapy, and an endocardial ablation device includes an inflatable member and at least one electrode for focal ablation pulse delivery to tissue. The signal generator may deliver voltage pulses to the ablation device in the form of a pulse waveform. The system may include a cardiac stimulator for generation of pacing signals and for sequenced delivery of pulse waveforms in synchrony with the pacing signal.Type: ApplicationFiled: March 12, 2020Publication date: July 2, 2020Applicant: Farapulse, Inc.Inventors: Raju VISWANATHAN, Gary L. LONG
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Patent number: 10687892Abstract: Systems, devices, and methods for electroporation ablation therapy are disclosed herein, including an inflatable member for positioning an ablation device within a pulmonary vein ostium. An apparatus can include first and second shafts moveable relative to one another, first and second electrodes configured to generate an electric field for ablating tissue, and an inflatable member disposed between the first and second electrodes. In some embodiments, the inflatable member is configured to transition from an undeployed configuration to a deployed configuration in response to movement of the first and second shafts. In some embodiments, the inflatable member in the deployed configuration can engage a wall of a pulmonary vein ostium and direct the electric field generated by the first and second electrodes toward the wall.Type: GrantFiled: September 19, 2019Date of Patent: June 23, 2020Assignee: Farapulse, Inc.Inventors: Gary L. Long, Raju Viswanathan, Jean-Luc Pageard, Benoit Thibault
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Publication number: 20200146741Abstract: An energy source for use with an electrosurgical system is disclosed. In one embodiment, the energy source includes a power supply, one or more capacitors coupled to the power supply, and a switching component coupled to the one or more capacitors. The switching component is configured to output pulses of a biphasic waveform. The pulses are capable of treating undesired tissue by inducing a change in voltage potential across cell membranes of a plurality of cells in the undesired tissue to promote non-thermal cell death in the plurality of cells. The pulses are also capable of treating the undesired tissue with no or minimal muscle contractions in patient tissue within reach of the biphasic waveform during treatment of the undesired tissue.Type: ApplicationFiled: July 8, 2019Publication date: May 14, 2020Inventors: Gary L. Long, Gregory J. Bakos, David N. Plescia
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Publication number: 20200093539Abstract: Systems, devices, and methods for electroporation ablation therapy are disclosed herein, including an inflatable member for positioning an ablation device within a pulmonary vein ostium. An apparatus can include first and second shafts moveable relative to one another, first and second electrodes configured to generate an electric field for ablating tissue, and an inflatable member disposed between the first and second electrodes. In some embodiments, the inflatable member is configured to transition from an undeployed configuration to a deployed configuration in response to movement of the first and second shafts. In some embodiments, the inflatable member in the deployed configuration can engage a wall of a pulmonary vein ostium and direct the electric field generated by the first and second electrodes toward the wall.Type: ApplicationFiled: September 19, 2019Publication date: March 26, 2020Applicant: Farapulse, Inc.Inventors: Gary L. LONG, Raju VISWANATHAN, Jean-Luc PAGEARD, Benoit THIBAULT