Abstract: The present invention relates to a method and apparatus for the isolation, modification and re-administration of a molecule or biomolecule, or a class of biomolecules, from the body fluid of a mammal via an extracorporeal closed circuit device. The device is able to capture and modify the biomolecule by the covalent or non-covalent attachment of a secondary molecule or protein, by cross-linking the captured molecule, or by altering the structure of the molecule (for example, by deglycosylation, peptide cleavage, or aggregation). The apparatus can be used to return the modified molecule or biomolecule to the mammalian subject. The device and methods may be utilized for the patient-specific diagnosis and/or treatment of a disease state which presents an associated molecule or protein in plasma or any other fluidized physiological system.

Abstract: The present invention relates to a method and apparatus for the isolation, modification and re-administration of a molecule or biomolecule, or a class of biomolecules, from the body fluid of a mammal via an extracorporeal closed circuit device. The device is able to capture and modify the biomolecule by the covalent or non-covalent attachment of a secondary molecule or protein, by cross-linking the captured molecule, or by altering the structure of the molecule (for example, by deglycosylation, peptide cleavage, or aggregation). The apparatus can be used to return the modified molecule or biomolecule to the mammalian subject. The device and methods may be utilized for the patient-specific diagnosis and/or treatment of a disease state which presents an associated molecule or protein in plasma or any other fluidized physiological system.

Abstract: The present invention relates to a method and apparatus for the isolation, modification and re-administration of a molecule or biomolecule, or a class of biomolecules, from the body fluid of a mammal via an extracorporeal closed circuit device. The device is able to capture and modify the biomolecule by the covalent or non-covalent attachment of a secondary molecule or protein, by cross-linking the captured molecule, or by altering the structure of the molecule (for example, by deglycosylation, peptide cleavage, or aggregation). The apparatus can be used to return the modified molecule or biomolecule to the mammalian subject. The device and methods may be utilized for the patient-specific diagnosis and/or treatment of a disease state which presents an associated molecule or protein in plasma or any other fluidized physiological system.

Abstract: The present invention provides methods and compositions for the preparation and delivery of chimeric cytokine proteins, including cell cultures, methods of purification and purified compositions.

Abstract: The present invention relates to a method and apparatus for the isolation, modification and re-administration of a molecule or biomolecule, or a class of biomolecules, from the body fluid of a mammal via an extracorporeal closed circuit device. The device is able to capture and modify the biomolecule by the covalent or non-covalent attachment of a secondary molecule or protein, by cross-linking the captured molecule, or by altering the structure of the molecule (for example, by deglycosylation, peptide cleavage, or aggregation). The apparatus can be used to return the modified molecule or biomolecule to the mammalian subject. The device and methods may be utilized for the patient-specific diagnosis and/or treatment of a disease state which presents an associated molecule or protein in plasma or any other fluidized physiological system.

Abstract: A chromatography cartridge assembly includes a cartridge and first and second end caps. A wall of the cartridge defines a chamber for containing chromatography media. The end caps define inlet and outlet passages, respectively, for flow of process fluid. The first end cap defines flow distributor passages for distributing process fluid across a cross-sectional area of the chamber, and the second end cap defines flow collector passages for collecting process fluid from across a cross-sectional area of the chamber. A clamp is circumferentially located about the cartridge wall for applying a radial load through the wall to the first end cap to fix the first end cap in a desired position.

Abstract: Apparatus for finishing parts or workpieces in the presence of liquid in a finishing chamber having outer upstanding wall and bottom members which are symmetrically arranged about a common axis and relatively rotatable about the axis, for imparting motion to the contents of the chamber for finishing of the parts or workpieces therein, and means for causing the relative motion, having an improved resilient seal between the bottom and the wall members in the form of a resiliently-restricted zone, comprising a partial bottom-forming lip or other partial bottom-forming element, and means for pumping fluid into said zone at a sufficient pressure so that the fluid enters the zone and then flows upwardly into the finishing chamber, is disclosed. Storage chambers below the bottom and adjacent the upstanding wall are employed for storage of fluid to be introduced into the finishing chamber.

Abstract: Apparatus for finishing parts or workpieces in the presence of liquid in a finishing chamber having outer upstanding wall and bottom members which are symmetrically arranged about a common axis and relatively rotatable about the axis, for imparting motion to the contents of the chamber for finishing of the parts or workpieces therein, and means for causing the relative motion, having an improved resilient seal between the bottom and the wall members in the form of a resiliently-restricted zone, comprising a partial bottom-forming lip or other partial bottom-forming element, and means for pumping fluid into said zone at a sufficient pressure so that the fluid enters the zone and thence flows upwardly into the finishing chamber, is disclosed. Storage chambers below the bottom and adjacent the upstanding wall are employed for storage of fluid to be introduced into the finishing chamber.

Abstract: A vibratory finishing machine for the surface finishing of workpieces comprising an essentially spiral trough, having a plurality of channels in side-by-side relationship, resiliently mounted for vibration and tilted with respect to the horizontal; such a spiral trough which is employed as a finishing chamber by attachment to a resiliently-mounted vibratory structure of a vibratory finishing machine; and a method and apparatus for vibratorily finishing a workpiece by subjecting it to a surface finishing medium in such a trough, having liquid finishing medium in only lower sections thereof and having solid finishing medium in an outer channel of said trough, are disclosed.

Abstract: A novel method for the surface-planing of the elongated parts, in which the parts are not submerged in the finishing media, and in which the direction of the finishing media orbit is in the direction of feed or of the longitudinal dimension of the part, is disclosed, as well as novel open-top finishing machines, comprising finishing chambers having internal flow diverters, and side walls lower than front and back walls, all especially adapted for carrying out the surface-planing method of the invention.

Abstract: A novel method of forming a finishing chamber by inserting a cylindrical tube into a corresponding opening in the bottom of a dished tank head having a bottom and an upwardly-extending outer wall, inserting a cone-shaped gusset or collar having an outwardly and downwardly-extending skirt and an opening in the top thereof, corresponding to the circumference of the cylindrical tube, over the tube and with its outer circumference in contact with the tank head, and welding the tube to the tank head and to the gusset and the gusset to the bottom of the tank head, thereby simply to provide the essentials of a finishing chamber, is disclosed. The outer wall of the finishing chamber may be extended by welding a sheetform annular ring to the top of the outer wall of the tank head, and the chamber may be lined with elastomer and fitted with a screen deck.

Abstract: A novel method for the surface-planing of elongated parts, in which the parts are not submerged in the finishing media, and in which the direction of the finishing media orbit is in the direction of feed or of the longitudinal dimension of the part, is disclosed, as well as novel open-top finishing machines, comprising finishing chambers having internal flow diverters, and side walls lower than front and back walls, all especially adapted for carrying out the surface-planing method of the invention.

Abstract: A novel method of forming a finishing chamber by inserting a cylindrical tube into a corresponding opening in the bottom of a dished tank head having a bottom and an upwardly-extending outer wall, inserting a cone-shaped gusset or collar having an outwardly and downwardly-extending skirt and an opening in the top thereof, corresponding to the circumference of the cylindrical tube, over the tube and with its outer circumference in contact with the tank head, and welding the tube to the tank head and to the gusset and the gusset to the bottom of the tank head, thereby simply to provide the essentials of a finishing chamber, is disclosed. The outer wall of the finishing chamber may be extended by welding a sheetform annular ring to the top of the outer wall of the tank head, and the chamber may be lined with elastomer and fitted with a screen deck.