Abstract: The present invention provides angiogenesis inhibitor compounds comprising a MetAP-2 inhibitory core coupled to a peptide, as well as pharmaceutical compositions comprising the angiogenesis inhibitor compounds and a pharmaceutically acceptable carrier. The present invention also provides methods of treating an angiogenic disease, e.g., cancer, in a subject by administering to the subject a therapeutically effective amount of one or more of the angiogenesis inhibitor compounds of the invention.

Abstract: The present invention provides methods of treating a parasitic infection, a lymphoid malignancy or an autoimmune disorder in a subject by administering to the subject a therapeutically effective amount of an angiogenesis inhibitor compound comprising a MetAP-2 inhibitory core coupled to a peptide.

Abstract: A mop assembly including a mop head and handle, and a supply of liquid connected to a valve assembly on the handle adjacent the mop head. The valve assembly includes a length of resiliently flexible tubing that has a portion extending transversely through the handle and first and second members on opposite sides of the length of tubing that are relatively movable between a closed position at which the first and second members pinch together opposite sides of the length of tubing to stop the flow of liquid through it, and an open position at which the first and second members are spaced apart to afford flow of liquid through it. Should the tubing become plugged, it can easily be replaced by disconnecting one end from a liquid supply length of tubing, withdrawing the tubing from between the first and second members, and then installing a new length of tubing.

Abstract: A mop assembly including a mop head and handle, and a supply of liquid connected to a valve assembly on the handle adjacent the mop head. The valve assembly includes a length of resiliently flexible tubing that has a portion extending transversely through the handle and first and second members on opposite sides of the length of tubing that are relatively movable between a closed position at which the first and second members pinch together opposite sides of the length of tubing to stop the flow of liquid through it, and an open position at which the first and second members are spaced apart to afford flow of liquid through it. Should the tubing become plugged, it can easily be replaced by disconnecting one end from a liquid supply length of tubing, withdrawing the tubing from between the first and second members, and then installing a new length of tubing.

Abstract: Compounds that modulate natural &bgr; amyloid peptide aggregation are provided. The modulators of the invention comprise a peptide, preferably based on a &bgr; amyloid peptide, that is comprised entirely of D-amino acids. Preferably, the peptide comprises 3-5 D-amino acid residues and includes at least two D-amino acid residues independently selected from the group consisting of D-leucine, D-phenylalanine and D-valine. In a particularly preferred embodiment, the peptide is a retro-inverso isomer of a &bgr; amyloid peptide, preferably a retro-inverso isomer of A&bgr;17-21. In certain embodiments, the peptide is modified at the amino-terminus, the carboxy-terminus, or both. Preferred amino-terminal modifying groups alkyl groups. Preferred carboxy-terminal modifying groups include an amide group, an acetate group, an alkyl amide group, an aryl amide group or a hydroxy group.

Abstract: Compounds that modulate natural &bgr; amyloid peptide aggregation are provided. The modulators of the invention comprise a peptide, preferably based on a &bgr; amyloid peptide, that is comprised entirely of D-amino acids. Preferably, the peptide comprises 3-5 D-amino acid residues and includes at least two D-amino acid residues independently selected from the group consisting of D-leucine, D-phenylalanine and D-valine. In a particularly preferred embodiment, the peptide is a retro-inverso isomer of a &bgr; amyloid peptide, preferably a retro-inverso isomer of A&bgr;17-21. In certain embodiments, the peptide is modified at the: amino-terminus, carboxy-terminus, or both. Preferred amino-terminal modifying groups alkyl groups. Preferred carboxy-terminal modifying groups include an amide group, an acetate group, an alkyl amide group, an aryl amide group or a hydroxy group.

Abstract: A dosing device is described, in which a predetermined amount of a material such as a concentrated fluid can be dispensed from the device by finger pressure. In one embodiment, the device includes a shuttle that can move between first and second positions. In the second position, fluid can escape from a dosing chamber.

Abstract: The present invention provides angiogenesis inhibitor compounds comprising a MetAP-2 inhibitory core coupled to a peptide, as well as pharmaceutical compositions comprising the angiogenesis inhibitor compounds and a pharmaceutically acceptable carrier. The present invention also provides methods of treating an angiogenic disease, e.g., cancer, in a subject by administering to the subject a therapeutically effective amount of one or more of the angiogenesis inhibitor compounds of the invention.

Abstract: The present invention provides angiogenesis inhibitor compounds comprising a MetAP-2 inhibitory core coupled to a peptide, as well as pharmaceutical compositions comprising the angiogenesis inhibitor compounds and a pharmaceutically acceptable carrier. The present invention also provides methods of treating an angiogenic disease, e.g., cancer, in a subject by administering to the subject a therapeutically effective amount of one or more of the angiogenesis inhibitor compounds of the invention.

Abstract: The present invention provides angiogenesis inhibitor compounds comprising a MetAP-2 inhibitory core coupled to a peptide, as well as pharmaceutical compositions comprising the angiogenesis inhibitor compounds and a pharmaceutically acceptable carrier. The present invention also provides methods of treating an angiogenic disease, e.g., cancer, in a subject by administering to the subject a therapeutically effective amount of one or more of the angiogenesis inhibitor compounds of the invention.

Abstract: The present invention provides angiogenesis inhibitor compounds comprising a MetAP-2 inhibitory core coupled to a peptide, as well as pharmaceutical compositions comprising the angiogenesis inhibitor compounds and a pharmaceutically acceptable carrier. The present invention also provides methods of treating an angiogenic disease, e.g., cancer, in a subject by administering to the subject a therapeutically effective amount of one or more of the angiogenesis inhibitor compounds of the invention.

Abstract: Undrawn, tough, durably melt-bondable, macrodenier, thermoplastic, multicomponent filaments, such as sheath-core and side-by-side filaments, comprising a first plastic component and a second lower-melting component defining all or at least part of the material-air boundary of the filaments. The filaments can be made by melt-extruding thermoplastics to form hot filaments, cooling and solidifying the hot filaments, and recovering the solidified filaments without any substantial tension being placed thereon. Aggregations of the filaments can be made in the form of floor matting and abrasive articles.

Abstract: A method for continuous tone imaging on a mat product having a web material with a three dimensional open structure provides a mat product with a sufficiently clear image. Moreover, it is a specific aspect of the present method to provide a clear image on such a three dimensional structure without negatively affecting the characteristics of the web material having the three dimensional structure. More specifically, the present invention is directed to a method for imaging a flexible high loft matting material which can be used in providing a floor covering mat product. The present invention is also directed to the imaged mat product produced in accordance with this method.

Abstract: Undrawn, tough, durably melt-bondable, macrodenier, thermoplastic, multicomponent filaments, such as sheath-core and side-by-side filaments, comprising a first plastic component and a second lower-melting component defining all or at least part of the material-air boundary of the filaments. The filaments can be made by melt-extruding thermoplastics to form hot filaments, cooling and solidifying the hot filaments, and recovering the solidified filaments without any substantial tension being placed thereon. Aggregations of the filaments can be made in the form of floor matting and abrasive articles.

Abstract: Undrawn, tough, durably melt-bondable, macrodenier, thermoplastic, multicomponent filaments, such as sheath-core and side-by-side filaments, comprising a first plastic component and a second lower-melting component defining all or at least part of the material-air boundary of the filaments. The filaments can be made by melt-extruding thermoplastics to form hot filaments, cooling and solidifying the hot filaments, and recovering the solidified filaments without any substantial tension being placed thereon. Aggregations of the filaments can be made in the form of floor matting and abrasive articles.

Abstract: Undrawn, tough, durably melt-bondable, macrodenier, thermoplastic, multicomponent filaments, such as sheath-core and side-by-side filaments, comprising a first plastic component and a second lower-melting component defining all or at least part of the material-air boundary of the filaments. The filaments can be made by melt-extruding thermoplastics to form hot filaments, cooling and solidifying the hot filaments, and recovering the solidified filaments without any substantial tension being placed thereon. Aggregations of the filaments can be made in the form of floor matting and abrasive articles.

Abstract: A collapsible container system for flowable materials includes a collapsible bag for holding the materials and a collapsible frame for supporting and retaining the bag. The collapsible frame includes top and bottom portions and a plurality of spaced apart upright members extending therebetween. The upright members each include a removable support portion that normally extends in a generally vertical direction and in supporting relation between the top and bottom portions. When all of the support portions are removed from supporting relation between the top and bottom portions the frame is collapsible and its height is reduced.

Abstract: A container system for flowable materials includes a frame having a bottom, front, rear, and at least one side. The frame includes a support tray disposed above the bottom and having a discharge chute. A pair of spaced apart tubes for receiving the forks of a forklift extend horizontally from the front to the rear of the frame below the support tray. The container system further includes a bag having a bottom portion adapted to rest on the support tray and having a discharge opening registered with the discharge chute. The bag has a flap that normally covers the discharge opening. A slide mechanism mounts at the side of the frame, transversely to the tubes, and is connected to the flap so as to peel it back to uncover the discharge opening and thereby dispense flowable material.

Abstract: Lofty, low density nonwoven pads and a process for the manufacture of such pads are described. The pads of the invention each comprise a bundle of discontinuous fibers bonded to one another at their mutual points of contact. The fibers are arranged within the bundle to provide a dense longitudinal central portion extending to opposite ends of the bundle, less dense side portions, a longitudinal tensile strength and a transverse tensile strength, wherein the longitudinal tensile strength is greater than the transverse tensile strength. The pads are made according to a process comprising forming a tow of discontinuous fibers so that the fibers are arranged within the tow to extend along a first axis, twisting the tow along the first axis to form a slubbed tow, bonding the fibers to one another at their mutual contact points and cutting the slubbed tow into scouring pads and the like.

Abstract: Abrasive articles comprising a plurality of abrasive particles, a combination of potassium tetrafluoroborate and a halogenated polymer, and a binder to which the plurality of abrasive particles are adhered, and methods of making and using the abrasive articles.