Patents by Inventor Gary Latham
Gary Latham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230198100Abstract: A busbar that includes a body having a first end corresponding to a first terminal contact area of the busbar, a second end opposite the first end, corresponding to a second terminal contact area of the busbar, and a spring-like middle portion located between the first end.Type: ApplicationFiled: December 20, 2022Publication date: June 22, 2023Inventors: Hoa The Tran, Nathan Schroeder, Gary Latham
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Publication number: 20210353804Abstract: An autonomous vehicle for applying a disinfecting/decontamination solution to surfaces within buildings, in outdoor spaces or other structures. The autonomous vehicle uses a dispensing system having an electrostatic charging mechanism which causes atomized dispensing fluid to be attracted to surfaces desired to be disinfected or decontaminated.Type: ApplicationFiled: May 14, 2021Publication date: November 18, 2021Inventors: Simon DEAN, Chris ANDREWS, Gary LATHAM
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Publication number: 20180163261Abstract: Embodiments are provided that relate to methods, systems, kits, computer-readable medium, and apparatuses comprising a computer-based variant calling model that incorporates the viable template count of the aliquot in calling a sequence of a target region based on a set of sequence reads.Type: ApplicationFiled: February 26, 2016Publication date: June 14, 2018Inventors: Robert ZEIGLER, Dennis WYLIE, Brian HAYNES, Gary LATHAM
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Patent number: 9464315Abstract: The invention relates to methods of separating polynucleotides, such as DNA, RNA and PNA, from solutions containing polynucleotides by reversibly binding the polynucleotides to a solid surface, such as a magnetic microparticle.Type: GrantFiled: March 25, 2013Date of Patent: October 11, 2016Assignee: Applied Biosystems, LLCInventors: Gary Latham, Xingwang Fang, Richard Conrad, Jon Kemppainen, Robert Setterquist, Brittan Pasloske
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Patent number: 9371560Abstract: Disclosed herein are methods for the automated reconstruction of a genotype of a gene, fragment, or genomic region using exhaustive enumeration. The methods can be used to reconstruct the genotype of any GC-rich sequence, such as the CGG repeat region in the 5? UTR of FMR1 or the CCG repeat region in the 5? UTR of FMR2. Also disclosed is an apparatus for use in conducting automated genotype reconstruction, as well as methods of diagnosis and treatment using exhaustive enumeration methods to reconstruct and identify genotypes associated with a disease or disorder.Type: GrantFiled: July 19, 2013Date of Patent: June 21, 2016Assignee: Asuragen, Inc.Inventors: Ashish Choudhary, Gary Latham, Sachin Sah
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Publication number: 20160160194Abstract: The present invention relates to a gene that encodes a hyperactive reverse transcriptase having DNA polymerase activity and substantially reduced RNase H activity, vectors containing the gene and host cells transformed with the invention. The present invention also includes a method of producing the hyperactive reverse transcriptase, producing cDNA from mRNA using the reverse transcriptase of the invention, kits and assay templates made using the hyperactive reverse transcriptase.Type: ApplicationFiled: December 22, 2014Publication date: June 9, 2016Inventors: LIANGJING CHEN, ROBERT SETTERQUIST, GARY LATHAM
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Patent number: 8956841Abstract: The present invention relates to a gene that encodes a hyperactive reverse transcriptase having DNA polymerase activity and substantially reduced RNase H activity, vectors containing the gene and host cells transformed with the invention. The present invention also includes a method of producing the hyperactive reverse transcriptase, producing cDNA from mRNA using the reverse transcriptase of the invention, kits and assay templates made using the hyperactive reverse transcriptase.Type: GrantFiled: December 28, 2012Date of Patent: February 17, 2015Assignee: Applied Biosystems, LLCInventors: Liangjing Chen, Robert Setterquist, Gary Latham
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Publication number: 20140024035Abstract: Disclosed herein are methods for the automated reconstruction of a genotype of a gene, fragment, or genomic region using exhaustive enumeration. The methods can be used to reconstruct the genotype of any GC-rich sequence, such as the CGG repeat region in the 5? UTR of FMR1 or the CCG repeat region in the 5? UTR of FMR2. Also disclosed is an apparatus for use in conducting automated genotype reconstruction, as well as methods of diagnosis and treatment using exhaustive enumeration methods to reconstruct and identify genotypes associated with a disease or disorder.Type: ApplicationFiled: July 19, 2013Publication date: January 23, 2014Applicant: ASURAGEN, INCInventors: Ashish Choudhary, Gary Latham, Sachin Sah
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Publication number: 20130302810Abstract: The invention relates to methods of separating polynucleotides, such as DNA, RNA and PNA, from solutions containing polynucleotides by reversibly binding the polynucleotides to a solid surface, such as a magnetic microparticle.Type: ApplicationFiled: March 25, 2013Publication date: November 14, 2013Inventors: Gary LATHAM, Xingwang Fang, Richard Conrad, Jon Kemppainen, Robert Setterquist, Brittan Pasloske
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Patent number: 8361754Abstract: The present invention relates to a gene that encodes a hyperactive reverse transcriptase having DNA polymerase activity and substantially reduced RNase H activity, vectors containing the gene and host cells transformed with the invention. The present invention also includes a method of producing the hyperactive reverse transcriptase, producing cDNA from mRNA using the reverse transcriptase of the invention, kits and assay templates made using the hyperactive reverse transcriptase.Type: GrantFiled: September 28, 2009Date of Patent: January 29, 2013Assignee: Applied Biosystems, LLCInventors: Liangjing Chen, Robert A. Setterquist, Gary Latham
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Publication number: 20110318811Abstract: Compositions and method for making and using a synthetic bovine DNase I are disclosed. More particularly, the sbDNase I of the present invention is a versatile enzyme that cleaves DNA nonspecifically to release 5?-phosphorylated nucleotides. The sbDNase I molecules of the present invention find particular use in a wide range of molecular biology applications, including: degradation of contaminating DNA after RNA isolation; RNA clean-up prior to, or in conjunction with, RT-PCR after in vitro transcription; identification of protein binding sequences on DNA (DNase I footprinting); prevention of clumping when handling cultured cells; tissue dissociation and creation of fragmented DNA for in vitro recombination reactions.Type: ApplicationFiled: May 9, 2011Publication date: December 29, 2011Applicant: APPLIED BIOSYSTEMS, LLCInventors: Gary Latham, Jon Kemppainen
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Publication number: 20100203597Abstract: The present invention relates to a gene that encodes a hyperactive reverse transcriptase having DNA polymerase activity and substantially reduced RNase H activity, vectors containing the gene and host cells transformed with the invention. The present invention also includes a method of producing the hyperactive reverse transcriptase, producing cDNA from mRNA using the reverse transcriptase of the invention, kits and assay templates made using the hyperactive reverse transcriptase.Type: ApplicationFiled: September 28, 2009Publication date: August 12, 2010Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Liangjing Chen, Robert A. Setterquist, Gary Latham
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Publication number: 20090286304Abstract: The present invention concerns a compositions and method for isolating a nucleic acid from a cell-containing sample. There is disclosed a method comprising obtaining at least one cell-containing sample, which comprises a cell containing nucleic acid, obtaining at least one catabolic enzyme, obtaining at least one nuclease inhibitor, preparing an admixture of the sample, the catabolic enzyme, and the nuclease inhibitor, maintaining the admixture under conditions where the catabolic enzyme is active, and agitating the admixture, where the sample is digested to produce a nucleic acid-containing lysate of the sample.Type: ApplicationFiled: May 11, 2009Publication date: November 19, 2009Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Gary Latham, Brittan L. Pasloske, Heidi Peltier
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Publication number: 20070032418Abstract: Lead compounds were obtained in a high throughput screen (HTS) of angiogenin (ANG; a potent inducer of angiogenesis) enzyme activity, an RNase. One lead was shown to delay appearance of tumors in an animal tumor system, and to reduce the number of animals having tumors. Several lead compound analogs were found to be even more potent inhibitors of ANG activity compared to the original leads, and two were also found to have greater affinity for ANG than for pancreatic RNase. Other embodiments disclose a method comprising obtaining a ribonuclease inhibitor and a composition; and admixing the ribonuclease inhibitor and the composition to form an admixture, wherein a ribonuclease that may be present in the admixture is inhibited.Type: ApplicationFiled: February 25, 2004Publication date: February 8, 2007Applicant: Ambion, IncInventors: Robert Shapiro, Jeremy Jenkins, Richard Kao, Gary Latham
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Publication number: 20060228731Abstract: Compositions and method for making and using a synthetic bovine DNase I are disclosed. More particularly, the sbDNase I of the present invention is a versatile enzyme that cleaves DNA nonspecifically to release 5?-phosphorylated nucleotides. The sbDNase I molecules of the present invention find particular use in a wide range of molecular biology applications, including: degradation of contaminating DNA after RNA isolation; RNA clean-up prior to, or in conjunction with, RT-PCR after in vitro transcription; identification of protein binding sequences on DNA (DNase I footprinting); prevention of clumping when handling cultured cells; tissue dissociation and creation of fragmented DNA for in vitro recombination reactions.Type: ApplicationFiled: February 23, 2006Publication date: October 12, 2006Applicant: Ambion, Inc.Inventors: Gary Latham, Jon Kemppainen
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Publication number: 20060188892Abstract: The present invention concerns a compositions and method for isolating a nucleic acid from a cell-containing sample. There is disclosed a method comprising obtaining at least one cell-containing sample, which comprises a cell containing nucleic acid, obtaining at least one catabolic enzyme, obtaining at least one nuclease inhibitor, preparing an admixture of the sample, the catabolic enzyme, and the nuclease inhibitor, maintaining the admixture under conditions where the catabolic enzyme is active, and agitating the admixture, where the sample is digested to produce a nucleic acid-containing lysate of the sample.Type: ApplicationFiled: March 9, 2005Publication date: August 24, 2006Inventors: Gary Latham, Brittan Pasloske, Heidi Peltier
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Patent number: 7067298Abstract: Compositions and method for making and using a synthetic bovine DNase I are disclosed. More particularly, the sbDNase I of the present invention is a versatile enzyme that cleaves DNA nonspecifically to release 5?-phosphorylated nucleotides. The sbDNase I molecules of the present invention find particular use in a wide range of molecular biology applications, including: degradation of contaminating DNA after RNA isolation; RNA clean-up prior to, or in conjunction with, RT-PCR after in vitro transcription; identification of protein binding sequences on DNA (DNase I footprinting); prevention of clumping when handling cultured cells; tissue dissociation and creation of fragmented DNA for in vitro recombination reactions.Type: GrantFiled: April 22, 2003Date of Patent: June 27, 2006Assignee: Ambion, Inc.Inventors: Gary Latham, Jon Kemppainen
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Publication number: 20050232934Abstract: The present invention relates to a gene that encodes a hyperactive reverse transcriptase having DNA polymerase activity and substantially reduced RNase H activity, vectors containing the gene and host cells transformed with the invention. The present invention also includes a method of producing the hyperactive reverse transcriptase, producing cDNA from mRNA using the reverse transcriptase of the invention, kits and assay templates made using the hyperactive reverse transcriptase.Type: ApplicationFiled: April 19, 2004Publication date: October 20, 2005Applicant: Ambion, Inc.Inventors: Liangjing Chen, Robert Setterquist, Gary Latham
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Publication number: 20050208510Abstract: The invention relates to methods of separating polynucleotides, such as DNA, RNA and PNA, from solutions containing polynucleotides by reversibly binding the polynucleotides to a solid surface, such as a magnetic microparticle.Type: ApplicationFiled: September 30, 2004Publication date: September 22, 2005Inventors: Gary Latham, Xingwang Fang, Richard Conrad, Jon Kemppainen, Robert Setterquist, Brittan Pasloske
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Publication number: 20050175268Abstract: A lubricating device and method for delivering fresh grease to a rolling element bearing in a first cavity, by by-passing all existing grease in the first cavity and in other cavities surrounding and/or leading to the rolling element bearing, and delivering fresh grease in close proximity to the rolling element bearing. A tube is disposed between the zerk fitting and the bearing to ensure delivery of the fresh new grease to the bearing.Type: ApplicationFiled: February 1, 2005Publication date: August 11, 2005Inventor: Gary Latham