Abstract: System/Method/Device for labelling images in an automated manner to satisfy a performance of a different algorithm and then applying active learning to learn a deep learning model which would enable ‘real-time’ operation of quality assessment and with high accuracy.

Abstract: Described herein are immunoresponsive cells engineered to express cytokines, chimeric receptors, and synthetic transcription factor systems. Also described herein are nucleic acids, cells, and methods directed to the same.

Abstract: Provided herein are mutants of estrogen receptor alpha ligand binding domain (ER-LBD), and chimeric proteins including such mutant ER-LBD. Also provided are methods of modulating transcription and modulating localization of such chimeric proteins.

Abstract: Provided herein are mutants of estrogen receptor alpha ligand binding domain (ER-LBD), and chimeric proteins including such mutant ER-LBD. Also provided are methods of modulating transcription and modulating localization of such chimeric proteins.

Abstract: Provided herein are mutants of estrogen receptor alpha ligand binding domain (ER-LBD), and chimeric proteins including such mutant ER-LBD. Also provided are methods of modulating transcription and modulating localization of such chimeric proteins.

Abstract: System/Method/Device for labelling images in an automated manner to satisfy a performance of a different algorithm and then applying active learning to learn a deep learning model which would enable ‘real-time’ operation of quality assessment and with high accuracy.

Abstract: Described herein are chimeric proteins, specifically membrane-cleavable chimeric systems. Also described herein are nucleic acids, cells, and methods directed to the same.

Abstract: Provided herein are solid tumor antigen targets for chimeric receptors and chimeric inhibitory receptors, and methods of using the same, such as for the treatment of cancer.

Abstract: Provided herein are inhibitory chimeric antigen receptor compositions and cells comprising such compositions. Also provided are methods of using inhibitory chimeric antigen receptors and cells.

Abstract: Provided herein are inhibitory chimeric antigen receptor compositions and cells comprising such compositions. Also provided are methods of using inhibitory chimeric antigen receptors and cells.

Abstract: The present invention provides a method for increasing the activity of a mutant or wild-type ?-glucosidase enzyme in vitro and in vivo by contacting the enzyme with a specific pharmacological chaperone which is a derivative of 1-deoxynojirimycin. The invention also provides a method for the treatment of Pompe disease by administration of chaperone small molecule compound which is a derivative of 1-deoxynojirimycin. The 1-deoxynojirimycin derivative is substituted at the N or C1 position. Combination therapy with replacement ?-glucosidase gene or enzyme is also provided.

Abstract: A system and method for fast-detection and mitigation of emerging network fraud attacks includes sourcing digital event data samples associated with one or more online services; executing graph-rendering computer instructions that automatically construct a backbone graph using a subset of features extracted from the sourced digital event data samples, wherein the constructing includes: identifying, as graphical nodes, a first plurality of distinct features of the subset of features; identifying, as graphical edges, a second plurality of distinct features of the subset of features; generating a graphical edge between distinct pairs of graphical nodes comprising a same type of feature of the subset of features based on feature values associated with at least one distinct feature of the second plurality of distinct features; and mitigating, via a digital threat mitigation action, if one or more emerging network fraud attacks is identified based on an assessment of a cluster of networked nodes.

Abstract: Provided herein are compositions and methods for regulating expression of effector molecules using regulatable transcription factors and/or activation inducible promoters.

Abstract: System for customizing visual field (VF) tests uses a machine learning model (15) trained on retina images (12A, 12C, 12D), including optical coherence tomography (OCT), optical coherence tomography angiography (OCTA), fundus, and/or fluorescein angiography images. In operation, in preparation for administering a specific VF test (13) to a patient, a retina image of the patient is submitted to the present machine model, which responds by synthesizing a VF prediction for the patient. The synthesized VF may be used to optimize the specific VF test prior to administering it to the patient.

Abstract: A system and method for fast-detection and mitigation of emerging network fraud attacks includes sourcing digital event data samples associated with one or more online services; executing graph-rendering computer instructions that automatically construct a backbone graph using a subset of features extracted from the sourced digital event data samples, wherein the constructing includes: identifying, as graphical nodes, a first plurality of distinct features of the subset of features; identifying, as graphical edges, a second plurality of distinct features of the subset of features; generating a graphical edge between distinct pairs of graphical nodes comprising a same type of feature of the subset of features based on feature values associated with at least one distinct feature of the second plurality of distinct features; and mitigating, via a digital threat mitigation action, if one or more emerging network fraud attacks is identified based on an assessment of a cluster of networked nodes.

Abstract: An ophthalmic imaging system has a specialized graphical user interface GUI to convey information for manually adjusting control inputs to bring an eye into alignment with the device. The GUI provides additional information such as laterality, visual alignment overlay aids, and live video feeds. The system further applies automatic gain control to fundus images, synchronizes itself with other ophthalmic systems on a computer network, and provides an optimized image load and display system.

Abstract: Systems and methods for controlling commits to a search platform in a content management system. Identification information of endpoints may be passed down from endpoints to the search platform. Endpoints may be grouped based on their identification information, and commit policies may be assigned to each group of endpoints. A commit request from an endpoint to the search platform may be intercepted, its group may be determined based on the endpoint identification information, and commit policy for that group may be applied to the commit request.

Abstract: An electronic device includes a foldable touch screen having first and second portions and a bendable intermediate portion connecting the first portion to the second portion. The foldable touch screen has a capacitive touch matrix therein. A touch screen controller acquires touch data from the capacitive touch matrix, calculates strength values of nodes of the capacitive touch matrix based upon the acquired touch data, calculates a first value, the first value being an average strength of nodes of the capacitive touch matrix located in the first portion of the foldable touch screen, calculates a second value, the second value being an average strength of nodes of the capacitive touch matrix located in the second portion of the foldable touch screen, and determines that the foldable touch screen is in a closed position based upon the first value and the second value both being greater than a first given strength value.

Abstract: An ophthalmic imaging system has a specialized graphical user interface GUI to convey information for manually adjusting control inputs to bring an eye into alignment with the device. The GUI provides additional information such as laterality, visual alignment overlay aids, and live video feeds. The system further applies automatic gain control to fundus images, synchronizes itself with other ophthalmic systems on a computer network, and provides an optimized image load and display system.

Abstract: The present invention provides novel compounds as well as compositions and methods using the same for preventing and/or treating degenerative disorders of the central nervous system. In particular, the present invention provides methods for preventing and/or treating Parkinson's disease.