Patents by Inventor Gary Lee Olson

Gary Lee Olson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Arginase Inhibitors and Methods of Use
    Publication number: 20200223871
    Abstract: The present invention is directed to arginase inhibitor compounds of formula IA or formula IB: or a pharmaceutically acceptable salt thereof, compositions containing these compounds, and methods of their use for the treatment and diagnosis of conditions characterized by upregulation of arginase, abnormally high arginase activity, or by abnormally low nitric oxide synthase activity.
    Type: Application
    Filed: August 22, 2019
    Publication date: July 16, 2020
    Applicants: AstraZeneca AB, The Trustees of the University of Pennsylvania
    Inventors: David W. Christianson, Bruce Edward Tomczuk, Richard Scott Pottorf, Andrew Vargha Colasanti, Gary Lee Olson
  • Arginase Inhibitors and Methods of Use
    Publication number: 20190127395
    Abstract: The present invention is directed to arginase inhibitor compounds of formula IA or formula IB: or a pharmaceutically acceptable salt thereof, compositions containing these compounds, and methods of their use for the treatment and diagnosis of conditions characterized by upregulation of arginase, abnormally high arginase activity, or by abnormally low nitric oxide synthase activity.
    Type: Application
    Filed: September 28, 2018
    Publication date: May 2, 2019
    Applicants: AstraZeneca AB, The Trustees of the University of Pennsylvania
    Inventors: David W. Christianson, Bruce Edward Tomczuk, Richard Scott Pottorf, Andrew Vargha Colasanti, Gary Lee Olson
  • Arginase inhibitors and methods of use
    Patent number: 10118936
    Abstract: The present invention is directed to arginase inhibitor compounds of formula IA or formula IB: or a pharmaceutically acceptable salt thereof, compositions containing these compounds, and methods of their use for the treatment and diagnosis of conditions characterized by upregulation of arginase, abnormally high arginase activity, or by abnormally low nitric oxide synthase activity.
    Type: Grant
    Filed: December 4, 2015
    Date of Patent: November 6, 2018
    Assignees: The Trustees of the University of Pennsylvania, AstraZeneca AB
    Inventors: David W. Christianson, Bruce Edward Tomczuk, Richard Scott Pottorf, Andrew Vargha Colasanti, Gary Lee Olson
  • Arginase inhibitors and methods of use thereof
    Patent number: 9447122
    Abstract: The present invention includes arginase enzyme inhibitors, compositions comprising these arginase inhibitors, and methods of treating or diagnosing conditions characterized either by abnormally high arginase activity or abnormally low nitric oxide levels in a mammal, comprising administering compositions of the invention to the mammal.
    Type: Grant
    Filed: March 19, 2015
    Date of Patent: September 20, 2016
    Assignee: AstraZeneca AB
    Inventors: Bruce Edward Tomczuk, Gary Lee Olson, Richard Scott Pottorf, Lijuan Jane Wang, Bhaskara Rao Nallaganchu, Yanqun Zhang
  • ARGINASE INHIBITORS AND METHODS OF USE
    Publication number: 20160194340
    Abstract: The present invention is directed to arginase inhibitor compounds of formula IA or formula IB: or a pharmaceutically acceptable salt thereof, compositions containing these compounds, and methods of their use for the treatment and diagnosis of conditions characterized by upregulation of arginase, abnormally high arginase activity, or by abnormally low nitric oxide synthase activity.
    Type: Application
    Filed: December 4, 2015
    Publication date: July 7, 2016
    Inventors: David W. CHRISTIANSON, Bruce Edward TOMCZUK, Richard Scott POTTORF, Andrew Vargha COLASANTI, Gary Lee OLSON
  • Arginase Inhibitors and Methods of Use Thereof
    Publication number: 20160039847
    Abstract: The present invention includes arginase enzyme inhibitors, compositions comprising these arginase inhibitors, and methods of treating or diagnosing conditions characterized either by abnormally high arginase activity or abnormally low nitric oxide levels in a mammal, comprising administering compositions of the invention to the mammal.
    Type: Application
    Filed: March 19, 2015
    Publication date: February 11, 2016
    Inventors: Bruce Edward Tomczuk, Gary Lee Olson, Richard Scott Pottorf, Lijuan Jane Wang, Bhaskara Rao Nallaganchu, Yanqun Zhang
  • Arginase inhibitors and methods of use thereof
    Patent number: 8894970
    Abstract: The present invention includes arginase enzyme inhibitors, compositions comprising these arginase inhibitors, and methods of treating or diagnosing conditions characterized either by abnormally high arginase activity or abnormally low nitric oxide levels in a mammal, comprising administering compositions of the invention to the mammal.
    Type: Grant
    Filed: July 26, 2011
    Date of Patent: November 25, 2014
    Assignee: Corridor Pharmaceuticals, Inc.
    Inventors: Bruce Edward Tomczuk, Gary Lee Olson, Richard Scott Pottorf, Lijuan Jane Wang, Bhaskara Rao Nallaganchu, Yanqun Zhang
  • Inhibitors of antigen presentation by MHC class II molecules
    Patent number: 8598312
    Abstract: The present invention relates to compounds, pharmaceutical compositions containing such compounds and methods for their use. In particular, the compounds of the invention are useful for the treatment or prevention of diseases associated with T cell proliferation such as autoimmune diseases and disorders.
    Type: Grant
    Filed: June 15, 2012
    Date of Patent: December 3, 2013
    Assignee: Provid Pharmaceuticals, Inc.
    Inventors: Gary Lee Olson, Charles Michael Cook, Christopher Raymond Self
  • INHIBITORS OF ANTIGEN PRESENTATION BY MHC CLASS II MOLECULES
    Publication number: 20120252734
    Abstract: The present invention relates to compounds, pharmaceutical compositions containing such compounds and methods for their use. In particular, the compounds of the invention are useful for the treatment or prevention of diseases associated with T cell proliferation such as autoimmune diseases and disorders.
    Type: Application
    Filed: June 15, 2012
    Publication date: October 4, 2012
    Inventors: Gary Lee Olson, Charles Michael Cook, Christopher Raymond Self
  • Methods for the use of inhibitors of antigen presentation by MHC class II molecules
    Patent number: 8222215
    Abstract: The present invention relates to compounds, pharmaceutical compositions containing such compounds and methods for their use. In particular, the compounds of the invention are useful for the treatment or prevention of diseases associated with T cell proliferation such as autoimmune diseases and disorders.
    Type: Grant
    Filed: September 5, 2008
    Date of Patent: July 17, 2012
    Assignee: Provid Pharmaceuticals, Inc.
    Inventors: Gary Lee Olson, Charles Michael Cook, Christopher Raymond Self
  • Arginase Inhibitors and Methods of Use Thereof
    Publication number: 20120171116
    Abstract: The present invention includes arginase enzyme inhibitors, compositions comprising these arginase inhibitors, and methods of treating or diagnosing conditions characterized either by abnormally high arginase activity or abnormally low nitric oxide levels in a mammal, comprising administering compositions of the invention to the mammal.
    Type: Application
    Filed: July 26, 2011
    Publication date: July 5, 2012
    Inventors: Bruce Edward Tomczuk, Gary Lee Olson, Richard Scott Pottorf, Jane Wang, Bhaskara Rao Nallaganchu
  • ARGINASE INHIBITORS AND METHODS OF USE
    Publication number: 20100189644
    Abstract: The present invention is directed to arginase inhibitor compounds of formula IA or formula IB: or a pharmaceutically acceptable salt thereof, compositions containing these compounds, and methods of their use for the treatment and diagnosis of conditions characterized by upregulation of arginase, abnormally high arginase activity, or by abnormally low nitric oxide synthase activity.
    Type: Application
    Filed: January 26, 2010
    Publication date: July 29, 2010
    Applicants: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, ARGINETIX, INC.
    Inventors: DAVID W. CHRISTIANSON, Bruce Edward Tomczuk, Richard Scott Pottorf, Andrew Vargha Colasanti, Gary Lee Olson
  • METHODS FOR THE USE OF INHIBITORS OF ANTIGEN PRESENTATION BY MHC CLASS II MOLECULES
    Publication number: 20090111755
    Abstract: The present invention relates to compounds, pharmaceutical compositions containing such compounds and methods for their use. In particular, the compounds of the invention are useful for the treatment or prevention of diseases associated with T cell proliferation such as autoimmune diseases and disorders.
    Type: Application
    Filed: September 5, 2008
    Publication date: April 30, 2009
    Inventors: Gary Lee Olson, Charles Michael Cook, Christopher Raymond Self
  • Inhibitors of antigen presentation by MHC class II molecules and methods of use thereof
    Publication number: 20040162242
    Abstract: The present invention relates to compounds, pharmaceutical compositions containing such compounds and methods for their use. In particular, the compounds of the invention are useful for the treatment or prevention of diseases associated with T cell proliferation such as autoimmune diseases and disorders.
    Type: Application
    Filed: February 13, 2004
    Publication date: August 19, 2004
    Inventors: Gary Lee Olson, Charles Michael Cook, Christopher Raymond Self
  • Pyran aldehydes
    Patent number: 4071538
    Abstract: A novel process for the preparation of polyene aldehydes which employs as starting materials, substituted 2H pyrans. Novel substituted 2H pyrans and polyene intermediates are also disclosed.
    Type: Grant
    Filed: October 8, 1976
    Date of Patent: January 31, 1978
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Gary Lee Olson
  • Vitamin A esters
    Patent number: 4022807
    Abstract: A process for producing vitamin A esters, vitamin A aldehyde and 3,7-dimethyl-9-(1-hydroxy-2,2,6-trimethylcyclohexyl)-nona-2,4,6-trien-8-yn -1-ol and vitamin A acid esters from esters of 3,7-dimethyl-9-(1-hydroxy-2,2,6-trimethylcyclohexyl)-nona-2,4,6-trien-8-yn oic acid including intermediates in this process.
    Type: Grant
    Filed: August 11, 1975
    Date of Patent: May 10, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Gary Lee Olson, Gabriel Saucy
  • Intermediate compounds for the preparation of polyene aldehydes
    Patent number: 3997529
    Abstract: A novel process for the preparation of polyene aldehydes which employs as starting materials, substituted 2H pyrans. Novel substituted 2H pyrans and polyene intermediates are also disclosed.
    Type: Grant
    Filed: October 1, 1975
    Date of Patent: December 14, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Gary Lee Olson
  • Process for producing a sulfone derivative of vitamin A alcohol
    Patent number: 3960967
    Abstract: A process for the preparation of vitamin A and esters thereof from the condensation of a sulfone of 2-methyl-4-hydroxy-but-2-ene and an activated derivative of 3-methyl-5-(2,6,6-trimethyl-cyclohexen-1-yl)penta-2,4-diene including intermediates therein.
    Type: Grant
    Filed: July 19, 1974
    Date of Patent: June 1, 1976
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Gary Lee Olson, Gabriel Saucy