Abstract: Provided are chimeric polypeptides which modulate various cellular processes following cleavage of a force sensor cleavage domain, including non-Notch force sensor cleavage domains, induced upon binding of a specific binding member of the chimeric polypeptide with its binding partner. Methods of using force sensor cleavage domain-containing chimeric polypeptides to modulate cellular functions, including e.g., modulation (including induction or repression) of gene expression, are also provided. Nucleic acids encoding the subject chimeric polypeptides and associated expression cassettes and vectors as well as cells that contain such nucleic acids and/or expression cassettes and vectors are provided. Also provided, are methods of monitoring cell-cell signaling and method of treating a subject using the described components, as well as kits for practicing the subject methods.

Abstract: A method and system are provided for continuously monitoring bandwidth utilization in real time on a backbone of a network. Prefixes using the highest traffic can be identified and additional bandwidth can be provisioned in the form of optical transponder wavelengths. The additional bandwidth can be an express path that passes directly through optical nodes (thereby bypassing transit network devices) to the destination optical node. A centralized controller can perform the monitoring of the network devices, decide that an express path needs to be generated, and control both the network device and the optical network nodes to generate the express path from the network device, through the optical network, to the destination network device. The controller can apply and remove IP static routes and IP addresses associated with an express path. Additionally, the controller can request the setup or tear-down of an optical wavelength within the optical network.

Abstract: A rack has a frame and a plurality of shelves. Each shelf has an enclosing frame member that has two first sides connected by two second sides, a connecting bar that connects the first sides at about the center of the first sides, a plurality of slots provided on the inner surfaces of the second sides, and a plurality of slats, each slat having opposing ends that are fitted into opposing slots at the second sides, and with each slat being connected to the connecting bar. At least one connector is provided for removably connecting each shelf to a portion of the frame.

Abstract: A rack has a frame and a plurality of shelves. Each shelf has an enclosing frame member that has two first sides connected by two second sides, a connecting bar that connects the first sides at about the center of the first sides, a plurality of slots provided on the inner surfaces of the second sides, and a plurality of slats, each slat having opposing ends that are fitted into opposing slots at the second sides, and with each slat being connected to the connecting bar. At least one connector is provided for removably connecting each shelf to a portion of the frame.

Abstract: A system for performing biological reactions is provided. The system includes a chip including a substrate and a plurality of reaction sites. The plurality of reaction sites are each configured to include a liquid sample of at most one nanoliter. Further, the system includes a control system configured to initiate biological reactions within the liquid samples. The system further includes a detection system configured to detect biological reactions on the chip. According to various embodiments, the chip includes at least 20000 reaction sites. In other embodiments, the chip includes at least 30000 reaction sites.

Abstract: A rack has a frame and a plurality of shelves. Each shelf has an enclosing frame member that has two first sides connected by two second sides, a connecting bar that connects the first sides at about the center of the first sides, a plurality of slots provided on the inner surfaces of the second sides, and a plurality of slats, each slat having opposing ends that are fitted into opposing slots at the second sides, and with each slat being connected to the connecting bar. At least one connector is provided for removably connecting each shelf to a portion of the frame.

Abstract: A method and system are provided for continuously monitoring bandwidth utilization in real time on a backbone of a network. Prefixes using the highest traffic can be identified and additional bandwidth can be provisioned in the form of optical transponder wavelengths. The additional bandwidth can be an express path that passes directly through optical nodes (thereby bypassing transit network devices) to the destination optical node. A centralized controller can perform the monitoring of the network devices, decide that an express path needs to be generated, and control both the network device and the optical network nodes to generate the express path from the network device, through the optical network, to the destination network device. The controller can apply and remove IP static routes and IP addresses associated with an express path. Additionally, the controller can request the setup or tear-down of an optical wavelength within the optical network.

Abstract: A system for performing biological reactions is provided. The system includes a chip including a substrate and a plurality of reaction sites. The plurality of reaction sites are each configured to include a liquid sample of at most one nanoliter. Further, the system includes a control system configured to initiate biological reactions within the liquid samples. The system further includes a detection system configured to detect biological reactions on the chip. According to various embodiments, the chip includes at least 20000 reaction sites. In other embodiments, the chip includes at least 30000 reaction sites.

Abstract: A rack has a frame and a plurality of shelves. Each shelf has an enclosing frame member that has two first sides connected by two second sides, a connecting bar that connects the first sides at about the center of the first sides, a plurality of slots provided on the inner surfaces of the second sides, and a plurality of slats, each slat having opposing ends that are fitted into opposing slots at the second sides, and with each slat being connected to the connecting bar. At least one connector is provided for removably connecting each shelf to a portion of the frame.

Abstract: A method and system are provided for continuously monitoring bandwidth utilization in real time on a backbone of a network. Prefixes using the highest traffic can be identified and additional bandwidth can be provisioned in the form of optical transponder wavelengths. The additional bandwidth can be an express path that passes directly through optical nodes (thereby bypassing transit network devices) to the destination optical node. A centralized controller can perform the monitoring of the network devices, decide that an express path needs to be generated, and control both the network device and the optical network nodes to generate the express path from the network device, through the optical network, to the destination network device. The controller can apply and remove IP static routes and IP addresses associated with an express path. Additionally, the controller can request the setup or tear-down of an optical wavelength within the optical network.

Abstract: A biological analysis device for performing capillary electrophoresis includes a voltage section configured to generate a voltage differential across a cathode connector and an anode connector, an optical detector system configured to detect light emission from a sample, a temperature regulation section, and a cartridge holding portion configured to receive at least a portion of a removable cartridge comprising one or more capillaries and a separation medium container. The biological analysis device may include one or more actuators configured to actuate components of the removable cartridge when the removable cartridge is received in the cartridge holding portion. Devices and methods relate to biological analysis.

Abstract: A rack has a frame and a plurality of shelves. Each shelf has an enclosing frame member that has two first sides connected by two second sides, a connecting bar that connects the first sides at about the center of the first sides, a plurality of slots provided on the inner surfaces of the second sides, and a plurality of slats, each slat having opposing ends that are fitted into opposing slots at the second sides, and with each slat being connected to the connecting bar. At least one connector is provided for removably connecting each shelf to a portion of the frame.

Abstract: A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lends can be a bi-convex lens.

Abstract: A closet organizer assembly has a first tower unit and a second tower unit, each tower unit having a plurality of shelves separated by vertical posts, each tower unit also having a plurality of top vertical posts, and a cantilevered shelf removably connected to the plurality of top vertical posts, with each cantilevered shelf having a border wall that includes a plurality of border wall openings. The assembly also includes a bridge shelf having a left end that is removably connected to the cantilevered shelf of the first tower unit, and a right end that is removably connected to the cantilevered shelf of the second tower unit.

Abstract: A rack has a frame and a plurality of shelves. Each shelf has an enclosing frame member that has two first sides connected by two second sides, a connecting bar that connects the first sides at about the center of the first sides, a plurality of slots provided on the inner surfaces of the second sides, and a plurality of slats, each slat having opposing ends that are fitted into opposing slots at the second sides, and with each slat being connected to the connecting bar. At least one connector is provided for removably connecting each shelf to a portion of the frame.

Abstract: A method for preparing a film carrier for sputtering of IC units placed thereon, the method comprising the steps of: providing a carrier of IC units; removing said units from the carrier; delivering said IC units to a flipper; inverting and delivering said units to a sputtering film frame; placing the units on said sputtering film frame in an array having a pre-determined clearance about adjacent units.

Abstract: A rack has a frame and a plurality of shelves. Each shelf has an enclosing frame member that has two first sides connected by two second sides, a connecting bar that connects the first sides at about the center of the first sides, a plurality of slots provided on the inner surfaces of the second sides, and a plurality of slats, each slat having opposing ends that are fitted into opposing slots at the second sides, and with each slat being connected to the connecting bar. At least one connector is provided for removably connecting each shelf to a portion of the frame.

Abstract: A closet organizer assembly has a first tower unit and a second tower unit, each tower unit having a plurality of shelves separated by vertical posts, each tower unit also having a plurality of top vertical posts, and a cantilevered shelf removably connected to the plurality of top vertical posts, with each cantilevered shelf having a border wall that includes a plurality of border wall openings. The assembly also includes a bridge shelf having a left end that is removably connected to the cantilevered shelf of the first tower unit, and a right end that is removably connected to the cantilevered shelf of the second tower unit.