Patents by Inventor Gary Luehr

Gary Luehr has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Glycyrrhetinic acid derivatives for use in treating hyperkalemia
    Patent number: 11858959
    Abstract: The present invention provides a compound of formula (I) or a salt thereof: (Formula (I)) wherein X, L, V, R1; R2, R3 and R4, are as defined herein. The claimed compounds inhibit the enzyme 11-hydroxysteroid dehydrogenase type 2 (11-HSD2) and as a result are useful in the treatment of hyperkalemia by preventing cortisol from being oxidised to cortisone and thus allowing it to occupy the mineralocorticoid receptor, thus stimulating potassium excretion.
    Type: Grant
    Filed: February 6, 2020
    Date of Patent: January 2, 2024
    Assignee: Ardelyx, Inc.
    Inventors: Dean Dragoli, Gary Luehr, Tao Chen, Jason Lewis, Michael Leadbetter
  • Glycyrrhetinic acid derivatives for treating hyperkalemia
    Patent number: 11768319
    Abstract: The present invention provides a compound of formula (I) or a salt thereof: (I) wherein X, L, V, R1, R2, R3 and R4, are as defined herein. These compounds are inhibitors of 11-hydroxysteroid dehydrogenase type 2 (11-HSD-2) and are used to treat hyperkalemia.
    Type: Grant
    Filed: August 6, 2018
    Date of Patent: September 26, 2023
    Assignee: Ardelyx, Inc.
    Inventors: Gary Luehr, Dean Dragoli, Michael Leadbetter, Tao Chen, Jason Lewis
  • GLYCYRRHETINIC ACID DERIVATIVES FOR TREATING HYPERKALEMIA
    Publication number: 20230273354
    Abstract: The present invention provides a compound of formula (I) or a salt thereof: wherein X, L, V, R1, R2, R3 and R4, are as defined herein.
    Type: Application
    Filed: January 24, 2023
    Publication date: August 31, 2023
    Applicant: Ardelyx, Inc.
    Inventors: Gary Luehr, Dean Dragoli, Michael Leadbetter, Tao Chen, Jason Lewis
  • Pegylated carfilzomib compounds
    Patent number: 11077198
    Abstract: The present invention provides a method of treating multiple myeloma using polymeric pegylated carfilzomib compounds, and pharmaceutically acceptable salts thereof, of Formula I wherein R1, R2, linker, PEG, n and o are as defined herein.
    Type: Grant
    Filed: April 23, 2020
    Date of Patent: August 3, 2021
    Assignee: AMGEN INC.
    Inventors: Gary Luehr, Shabbir T. Anik, Ge Peng, Irina Dotsenko, Pasit Phiasivongsa, Dante Romanini
  • GLYCYRRHETINIC ACID DERIVATIVES FOR TREATING HYPERKALEMIA
    Publication number: 20210163524
    Abstract: The present invention provides a compound of formula (I) or a salt thereof: (I) wherein X, L, V, R1, R2, R3 and R4, are as defined herein. These compounds are inhibitors of 11-hydroxysteroid dehydrogenase type 2 (11-HSD-2) and are used to treat hyperkalemia.
    Type: Application
    Filed: August 6, 2018
    Publication date: June 3, 2021
    Applicant: Ardelyx, Inc.
    Inventors: Gary Luehr, Dean Dragoli, Michael Leadbetter, Tao Chen, Jason Lewis
  • Pegylated Carfilzomib Compounds
    Publication number: 20200376131
    Abstract: The present invention provides a method of treating multiple myeloma using polymeric pegylated carfilzomib compounds, and pharmaceutically acceptable salts thereof, of Formula I wherein R1, R2, linker, PEG, n and o are as defined herein.
    Type: Application
    Filed: April 23, 2020
    Publication date: December 3, 2020
    Applicant: AMGEN INC.
    Inventors: Gary LUEHR, Shabbir T. ANIK, Ge PENG, Irina DOTSENKO, Pasit PHIASIVONGSA, Dante ROMANINI
  • Pegylated carfilzomib compounds
    Patent number: 10675353
    Abstract: The present invention provides a method of treating multiple myeloma using polymeric pegylated carfilzomib compounds, and pharmaceutically acceptable salts thereof, of Formula I wherein R1, R2, linker, PEG, n and o are as defined herein.
    Type: Grant
    Filed: November 5, 2019
    Date of Patent: June 9, 2020
    Assignee: AMGEN INC.
    Inventors: Gary Luehr, Shabbir T. Anik, Ge Peng, Irina Dotsenko, Pasit Phiasivongsa, Dante Romanini
  • PEGYLATED CARFILZOMIB COMPOUNDS
    Publication number: 20200069808
    Abstract: The present invention provides a method of treating multiple myeloma using polymeric pegylated carfilzomib compounds, and pharmaceutically acceptable salts thereof, of Formula I wherein R1, R2, linker, PEG, n and o are as defined herein.
    Type: Application
    Filed: November 5, 2019
    Publication date: March 5, 2020
    Inventors: Gary LUEHR, Shabbir T. ANIK, Ge PENG, Irina DOTSENKO, Pasit PHIASIVONGSA, Dante ROMANINI
  • Pegylated carfilzomib compounds
    Patent number: 10517954
    Abstract: The present invention provides polymeric pegylated carfilzomib compounds, and pharmaceutically acceptable salts thereof, of Formula I wherein R1, R2, linker, PEG, n and o are as defined herein. The invention also provides methods of making and using these compounds to treat cancer, and particularly to treat hematological malignancies including multiple myeloma.
    Type: Grant
    Filed: May 23, 2017
    Date of Patent: December 31, 2019
    Assignee: Amgen Inc.
    Inventors: Gary Luehr, Shabbir T. Anik, Ge Peng, Irina Dotsenko, Pasit Phiasivongsa, Dante Romanini
  • PEGYLATED CARFILZOMIB COMPOUNDS
    Publication number: 20170340746
    Abstract: The present invention provides polymeric pegylated carfilzomib compounds, and pharmaceutically acceptable salts thereof, of Formula I wherein R1, R2, linker, PEG, n and o are as defined herein. The invention also provides methods of making and using these compounds to treat cancer, and particularly to treat hematological malignancies including multiple myeloma.
    Type: Application
    Filed: May 23, 2017
    Publication date: November 30, 2017
    Inventors: Gary LUEHR, Shabbir T. ANIK, Ge PENG, Irina DOTSENKO, Pasit PHIASIVONGSA, Dante ROMANINI
  • Prodrugs of peptide epoxy ketone protease inhibitors
    Patent number: 9315542
    Abstract: This disclosure features compounds that are useful as pro-drugs of epoxy ketone protease inhibitors.
    Type: Grant
    Filed: September 30, 2013
    Date of Patent: April 19, 2016
    Assignee: Onyx Therapeutics, Inc.
    Inventors: Pasit Phiasivongsa, Gary Luehr, Ge Peng, Kolbot By, Shabbir T. Anik
  • Prodrugs of Peptide Epoxy Ketone Protease Inhibitors
    Publication number: 20140105921
    Abstract: This disclosure features compounds that are useful as pro-drugs of epoxy ketone protease inhibitors.
    Type: Application
    Filed: July 9, 2013
    Publication date: April 17, 2014
    Inventors: Pasit Phiasivongsa, Gary Luehr, Ge Peng, Kolbot By, Shabbir T. Anik
  • Prodrugs of Peptide Epoxy Ketone Protease Inhibitors
    Publication number: 20140100168
    Abstract: This disclosure features compounds that are useful as pro-drugs of epoxy ketone protease inhibitors.
    Type: Application
    Filed: July 9, 2013
    Publication date: April 10, 2014
    Inventors: Pasit Phiasivongsa, Gary Luehr, Ge Peng, Kolbot By, Shabbir T. Anik
  • Prodrugs of Peptide Epoxy Ketone Protease Inhibitors
    Publication number: 20140100154
    Abstract: This disclosure features compounds that are useful as pro-drugs of epoxy ketone protease inhibitors.
    Type: Application
    Filed: September 30, 2013
    Publication date: April 10, 2014
    Applicant: Onyx Therapeutics, Inc.
    Inventors: Pasit Phiasivongsa, Gary Luehr, Ge Peng, Kolbot By, Shabbir T. Anik
  • 7-Fluoro-1,3-dihydro-indol-2-one oxazolidinones as antibacterial agents
    Patent number: 7435751
    Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof wherein R1 is C1-4alkyl, optionally substituted with a fluoro atom, or R1 is a cyclopropyl or cyclopropylmethyl; and R2 is methyl or ethyl. These compounds are useful as antibacterial agents.
    Type: Grant
    Filed: March 30, 2006
    Date of Patent: October 14, 2008
    Inventors: Vara Prasad Venkata Nagendra Josyula, Mikhail Gordeev, Gary Luehr
  • N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
    Publication number: 20070015801
    Abstract: The present invention provides antibacterial agents having the formulae I, II, and III described herein.
    Type: Application
    Filed: September 21, 2006
    Publication date: January 18, 2007
    Inventors: Richard Thomas, Toni-Jo Poel, Michael Barbachyn, Mikhail Gordeev, Gary Luehr, Adam Renslo, Upinder Singh, Vara Nagendra Josyula
  • Oxindole oxazolidinone as antibacterial agent
    Publication number: 20060229348
    Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof wherein R1 is C1-4alkyl, optionally substituted with a fluoro atom, or R1 is a cyclopropyl or cyclopropylmethyl; and R2 is methyl or ethyl. The compound is useful as antibacterial agents.
    Type: Application
    Filed: March 30, 2006
    Publication date: October 12, 2006
    Inventors: Vara Prasad Josyula, Gary Luehr, Mikhail Gordeev
  • 7-Fluoro-1,3-dihydro-indol-2-one oxazolidinones as antibacterial agents
    Publication number: 20060229349
    Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof wherein R1 is C1-4alkyl, optionally substituted with a fluoro atom, or R1 is a cyclopropyl or cyclopropylmethyl; and R2 is methyl or ethyl. These compounds are useful as antibacterial agents.
    Type: Application
    Filed: March 30, 2006
    Publication date: October 12, 2006
    Inventors: Vara Prasad Josyula, Mikhail Gordeev, Gary Luehr
  • Oxazolidinones containing oxindoles as antibacterial agents
    Publication number: 20060030609
    Abstract: The present invention relates to novel oxazolidinones derivatives of oxindoles of formula I, or a pharmaceutically acceptable salt thereof wherein Y1 is —CH— or —CF—; R1 is —C1-4alkyl, optionally substituted with a fluoro atom, or R1 is —C3-5cycloalkyl; and R2 is —H or —CH3. These compounds are useful as antibacterial agents.
    Type: Application
    Filed: July 28, 2005
    Publication date: February 9, 2006
    Inventors: Gary Luehr, Rama Jain, Adam Renslo, Vara Prasad Josyula, Mikhail Gordeev
  • Antimicrobial dihydrothiazine and dihydrothiopyran oxazolidinones
    Publication number: 20050143376
    Abstract: The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof wherein A, X, Y, Z, R2, R3, R4, R5, and R6 are as defined herein. The compounds of formula I are useful as antimicrobials against a number of human and veterinary pathogens.
    Type: Application
    Filed: February 22, 2005
    Publication date: June 30, 2005
    Inventors: Mikhail Gordeev, Adam Renslo, Gary Luehr, Stuart Lam, Neil Westlund, Dinesh Patel