Patents by Inventor Gary M. Brittenham

Gary M. Brittenham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190110718
    Abstract: An apparatus and method for noninvasive measurement of a fluorescent analyte concentration in the blood of a patient by exciting the blood and the analyte at two wavelength ranges and measuring the emission spectrum of the fluorescent analyte when (i) the difference of emission intensities at the excitation wavelength ranges of the fluorescent analyte is greater than that of background fluorophores, and (ii) when blood absorbance at the two excitation wavelength ranges is similar. An apparatus and method for measurement of a fluorescent analyte concentration in the blood of a patient is provided.
    Type: Application
    Filed: May 10, 2018
    Publication date: April 18, 2019
    Inventors: Gary M. Brittenham, Herbert Stepp, Georg Hennig
  • Patent number: 9999382
    Abstract: An apparatus and method for noninvasive measurement of a fluorescent analyte concentration in the blood of a patient by exciting the blood and the analyte at two wavelength ranges and measuring the emission spectrum of the fluorescent analyte when (i) the difference of emission intensities at the excitation wavelength ranges of the fluorescent analyte is greater than that of background fluorophores, and (ii) when blood absorbance at the two excitation wavelength ranges is similar. An apparatus and method for measurement of a fluorescent analyte concentration in the blood of a patient is provided.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: June 19, 2018
    Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Gary M Brittenham, Herbert Stepp, Georg Hennig
  • Publication number: 20140235973
    Abstract: An apparatus and method for noninvasive measurement of a fluorescent analyte concentration in the blood of a patient by exciting the blood and the analyte at two wavelength ranges and measuring the emission spectrum of the fluorescent analyte when (i) the difference of emission intensities at the excitation wavelength ranges of the fluorescent analyte is greater than that of background fluorophores, and (ii) when blood absorbance at the two excitation wavelength ranges is similar. An apparatus and method for measurement of a fluorescent analyte concentration in the blood of a patient is provided.
    Type: Application
    Filed: March 14, 2014
    Publication date: August 21, 2014
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Gary M Brittenham, Herbert Stepp, Georg Hennig
  • Patent number: 8513945
    Abstract: Exemplary embodiments of system, method and computer-accessible medium can be provided in accordance with the present disclosure can be provided for generating a plurality of images associated with at least one anatomical structure using magnetic resonance imaging (MRI) data. For example, using such exemplary embodiments, it is possible to obtain at least one multi-echo fast spin-echo (FSE) pulse sequence based on the MRI data, which can include, e.g., hardware specifications of the MRI system. Further, it is possible to generate each of the images based on a particular arrangement of multiple echoes produced by the multi-echo FSE pulse sequence(s).
    Type: Grant
    Filed: April 5, 2010
    Date of Patent: August 20, 2013
    Assignees: New York University, The Trustees of Columbia University in the City of New York
    Inventors: Daniel Kim, Jens H. Jensen, Gary M. Brittenham
  • Publication number: 20120294826
    Abstract: The present invention provides, inter alia, methods for ameliorating an adverse effect in a patient caused by an acute transfusion into the patient of a composition containing aged red blood cells using an iron chelator. Apparatuses and kits for ameliorating such adverse effects are also provided.
    Type: Application
    Filed: December 1, 2011
    Publication date: November 22, 2012
    Inventors: Steven L. Spitalnik, Eldad A. Hod, Gary M. Brittenham
  • Patent number: 8040128
    Abstract: According to one embodiment, an apparatus comprises a magnet assembly to produce a static magnetic field and a set of high-Tc flux transformers to detect a flux change from an item when the item is subjected to the static magnetic field produced by the magnet assembly and to produce a current based on the flux change. Additionally, the apparatus comprises a set of magnetoresistive sensors to detect a field produced by a current produced in the set of high-Tc flux transformers and a scanning mechanism to produce cyclic relative motion between the apparatus and the item. Furthermore, the apparatus comprises a magnetic shield to shield the magnetoresistive sensors, where the shield is an open ended cylinder made from mu-metal, where mu-metal is a very high magnetic permeability iron-nickel alloy. The apparatus additionally comprises a water interface mechanism to fill a gap between the apparatus and the item with water.
    Type: Grant
    Filed: April 14, 2009
    Date of Patent: October 18, 2011
    Inventors: David E. Farrell, Christopher J. Allen, Gary M. Brittenham
  • Publication number: 20100301860
    Abstract: Exemplary embodiments of system, method and computer-accessible medium can be provided in accordance with the present disclosure can be provided for generating a plurality of images associated with at least one anatomical structure using magnetic resonance imaging (MRI) data. For example, using such exemplary embodiments, it is possible to obtain at least one multi-echo fast spin-echo (FSE) pulse sequence based on the MRI data, which can include, e.g., hardware specifications of the MRI system. Further, it is possible to generate each of the images based on a particular arrangement of multiple echoes produced by the multi-echo FSE pulse sequence(s).
    Type: Application
    Filed: April 5, 2010
    Publication date: December 2, 2010
    Applicant: New York University
    Inventors: Daniel Kim, Jens H. Jensen, Gary M. Brittenham
  • Publication number: 20090322322
    Abstract: According to one embodiment, an apparatus comprises a magnet assembly to produce a static magnetic field and a set of high-Tc flux transformers to detect a flux change from an item when the item is subjected to the static magnetic field produced by the magnet assembly and to produce a current based on the flux change. Additionally, the apparatus comprises a set of magnetoresistive sensors to detect a field produced by a current produced in the set of high-Tc flux transformers and a scanning mechanism to produce cyclic relative motion between the apparatus and the item. Furthermore, the apparatus comprises a magnetic shield to shield the magnetoresistive sensors, where the shield is an open ended cylinder made from mu-metal, where mu-metal is a very high magnetic permeability iron-nickel alloy. The apparatus additionally comprises a water interface mechanism to fill a gap between the apparatus and the item with water.
    Type: Application
    Filed: April 14, 2009
    Publication date: December 31, 2009
    Applicant: Case Western Reserve University
    Inventors: David E. FARRELL, Christopher J. Allen, Gary M. Brittenham
  • Patent number: 5233992
    Abstract: A subject (22), such as a human patient, is positioned with a region of interest (24), such as the liver, close proximity to a phantom (12). A Volume image through the liver, the phantom, and adjacent portions of the subject are collected (40) with a magnetic resonance scanner. The phase component of the magnetic resonance data is reconstructed (50) into a three-dimensional phase map. An actually measured field map H.sub.m (r) is determined (42) from the phase map. A geometric model of the volumes occupied by the liver, the phantom, and adjacent portions of the subject are defined mathematically (44). A calculation routine (46) calculates a calculated or estimated field map H.sub.c (r) of the distortions to the magnetic field in the phantom which would be caused by the model.
    Type: Grant
    Filed: July 22, 1991
    Date of Patent: August 10, 1993
    Assignee: Edison Biotechnology Center
    Inventors: Randall W. Holt, Pedro J. Diaz, Errol M. Bellon, Gary M. Brittenham
  • Patent number: 5059395
    Abstract: In particle analysis applied to blood cells, use is made of a distinguishing parameter which is the ratio of pulse height to pulse width derived from individual pulses generated in response to detection of corresponding individual particles. The distribution of the distinguishing parameter is plotted on a distribution of pulse height and pulse width, and a three-dimensional display of pulse height, pulse width and the distinguishing parameter is used in analyzing the particles.
    Type: Grant
    Filed: November 9, 1988
    Date of Patent: October 22, 1991
    Assignee: Toa Medical Electronics Co., Ltd.
    Inventors: Gary M. Brittenham, Christopher J. Allen, Tokuhiro Okada, Keiji Fujimoto